Food and Celiac Disease Antibodies in Diarrhea-Predominant Irritable Bowel Syndrome Food and Celiac Disease Antibodies in IBS-D

Article Sidebar

13-March-2745.pdf
Published Mar 31, 2022
DOI: https://doi.org/10.18103/mra.v10i3.2745

Downloads

Download data is not yet available.

Main Article Content

Toshimi Chiba
Division of Internal Medicine, Department of Oral Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan
Maiko Mori
Ajinomoto Co., Inc., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 104-8315, Japan
Yuka Ikenoue
Research Institute, EA Pharma Co., Ltd., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-8681, Japan
Kazuyuki Suzuki
Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan

Abstract

Background: Some foods can exacerbate the symptoms of irritable bowel syndrome (IBS), although the associations between the pathophysiology of IBS and IgG food antibodies levels are not well known. We examined IgG antibodies elicited in response to food and celiac disease in diarrhea-predominant IBS (IBS-D).


Methods: Twenty patients with IBS-D and 20 healthy controls (HC), were enrolled. Serum immunoglobulin (Ig) G antibodies to 88 dietary items were measured and scored in accordance with the rate of antibody positivity. Serum tissue transglutaminase-IgA (tTG-IgA) and IgA endomysial antibody (EMA) were measured as markers of celiac disease. Serum IgE antibodies were also measured.


Results: For the 88-item food-related IgG scores there was no significant difference in the number of dietary items with a ≥ 0.5 IgG score between the IBS and HC groups. Total IgG scores between groups were not significantly different. Scores for wheat, rye, and oats were not significantly different for the IBS versus the HC group. IgG scores for apples were significantly higher in the IBS versus the HC group. Serum tTG-IgA and EMA titers were negative in both groups and not significantly different between groups. Serum IgE was also not significantly different between groups. One patient with high titers for wheat, rye, and oats had duodenal mucosa histology classified as Marsh 1 and was negative for human leukocyte antigen DQ haplotypes HLA-DQ2/HLA-DQ8.


Conclusions: We investigated IgG antibodies to food, tTG-IgA, and EMA in patients with IBS-D in whom IgG levels are likely influenced by dietary habits.

Keywords: Food antibodies, Celiac disease antibodies, Celiac disease, Diarrhea-predominant irritable bowel syndrome

Article Details

How to Cite
CHIBA, Toshimi et al. Food and Celiac Disease Antibodies in Diarrhea-Predominant Irritable Bowel Syndrome. Medical Research Archives, [S.l.], v. 10, n. 3, mar. 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2745>. Date accessed: 20 apr. 2024. doi: https://doi.org/10.18103/mra.v10i3.2745.
ABNT APA BibTeX CBE EndNote - EndNote format (Macintosh & Windows) MLA ProCite - RIS format (Macintosh & Windows) RefWorks Reference Manager - RIS format (Windows only) Turabian
Issue
Vol 10 No 3 (2022): Vol.10 Issue 3 March 2022
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

References

1. Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 2012 Jul;10(7):712-21.
2. Fukudo S, Okumura T, Inamori M, et al. Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. J Gastroenterol 2021 Mar;56(3):193-217.
3. Zar S, Kumar D, Benson MJ. Review article: food hypersensitivity and irritable bowel synderome. Aliment Pharm Ther 2001 Apr;15(4):439-49.
4. Guo H, Jiang T, Wang J, et al. The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel synderome with diarrhoea. J Int Med Res 2012;40(1):204-10.
5. Hunter JO. Food elimination in IBS: the case for IgG testing remains doubtful. Gut 2005 Aug;54(8):1203.
6. Bischoff SC, Crowe SE. Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology 2005 Apr;128(4):1089-113.
7. Nanda R, James R, Smith H, et al. Food intolerasnce and the irritable bowel syndrome. Gut 1989 Aug;30(8):1099-104.
8. Dainese R, Galliani EA, De Lazzari F, Di Leo V, Naccarato R. Discrepancies between reported food intolerance and sensitization test findings in irraitable bowel syndrome patienbts. Am J Gastroenterol 1999 Jul;94(7):1892-7.
9. Roudebush P. Diagnosis and Management of Adverse food reactions. In: Bonagura JD, editors. Kirk's Current Veterinary Therapy XII. Philadelphia: W.B. Saunders Co. 1995; 59-64.
10. Spergel JM, Brown-Whitehorn T. The use of patch testing in the diagnosiss of food allergy. Curr Allergy Asthma Rep 2005 Jan;5(1):86-90.
11. Zwetchkenbaum J, Burakoff R. The irritable bowel syndrome and food hypersensitivity. Ann Allerg 1988 Jul;61(1):47-9.
12. Ptitpierre J, Gumowski P, Girard JP. Irritable bowel syndrome and hypersensitivity to food. Ann Allergy 1985 Jun;54(6):538-40.
13. Barau E, Dupont C. Modifications of intestinal permeability during food provocation procedures in pediatric irritable bowel syndrome. J Pediatr Gastroenterol Nutr 1990 Jul;11(1):72-7.
14. Roussos A, Koursarakos P, Patsopoulos D, et al. Increased prevalence of irritable bowel syndrome in patients with bronchial asthma. Respir Med 2003 Jan;97(1):75-9.
15. Morcos A, Dinan T, Quigley EM. Irritable bowel syndrome: role of food in pathogenesis and management. J Dig Dis 2009 Nov;10(4):237-46.
16. Crowe SE, Perdue MH. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology 1992 Sep;103(3):1075-95.
17. Host A, Husby S, Gjesing B, et al. Prospective estimation of IgG, IgG subclass and IgE antibodies to dietary proteins in infants with cow’s milk allergy. Levels of antibodies to whole milk protein. BLG and ovaclbumin in relation to repeated milk challenge and clinical course of cow’s milk allergy. Allergy 1992 Jun;47(3):218-29.
18. Awazuhara H, Kawai H, Maruchi N. Major allergens in soybean and clinical significance of IgG4 antibodies investigated by IgE and IgG4 immunoblotting with sera from soybean-sensitive patients. Clin Exp Allergy 1997 Mar;27(3):325-32.
19. Dunphy RC, Verne GN. Drug treatment options for irritable bowel syndrome: managing for success. Drugs Aging 2001;18(3):201-211.
20. Villanueva A, Dominguez-Munoz JE, Mearin F. Update in the therapeutic management of irritable bowel syndrome. Dig Dis 2001;19(3):244-50.
21. Drisko J, Bishoff B, Hall M, et al. Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. J Am Coll Nutr 2006 Dec;25(6):514-22.
22. Zuo XL, Li YQ, Guo YT, et al. Alterations of food antigen-specific serum immunogloblins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy 2007 Jun;37(6):823-30.
23. Zar S, Benson MJ, Kumar D. Food-speciffic serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol 2005 Jul;100(7):1550-7.
24. Ligaarden SC, Lydersen S, Farup PG. IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population. BMC Gastroenterol 2012 Nov 21;12:166.
25. Monsbakken KW, Vandvik PO, Farup PG. Perceived food intolerance in subjects with irritable bowel syndrome-etiology, prevalence and consequence. Eur J Clin Nutr 2006 May;60(5):667-72.
26. Simren M, Mansson A, Langkilde AM, et al. Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 2001; 63(2):108-15.
27. Stapel SO, Asero R, Ballmer-Weber BK, et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008 Jul;63(7):793-6.
28. Mawdsley JE, Irving P, Markins R. IgG antibodies to foods in IBS. Gut 2005 Apr;54(4):567.
29. Sewell WA. IgG food antibodies should be studied in similarly treated group. Gut 2005 Apr;54(4):566.
30. Croft NM. IgG food antibodies and irritating the bowel. Gastroenterology 2005 Apr;128(4):1135-1136.
31. Ford AC, Chey WD, Talley NJ, et al. Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis. Arch Int Med 2009 Apr 13;169(7):651-8.
32. Korkut E, Bektas M, Oztas E, et al. The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome. Eur J Int Med 2010 Oct;21(5):389-92.
33. El-Salhy M, Lomholt-Beck B, Gundersen D. The prevalence of celiac disease in patients with irritable bowel syndrome. Mol Med Rept 2011 May-Jun;4(3):403-5.
34. Cash BD, Rubenstein JH, Young PE, et al. The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome in similar to controls. Gastroenterology 2011 Oct;141(4):1187-93.
35. Biesielierski JR, Newham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-control tiral. Am J Gastroenterol 2011 Mar;106(3):508-14.
36. Schoenfeld PS. Irritable bowel syndrome and gluten sensitivity without celiac disease: separating the wheat from the chaff. Gastroenterology 2012 Mar;142(3):664-6.
37. Brown NK, Guandalini S, Semrad C, Kupfer SS. A Clinician’s Guide to Celiac Disease HLA Genetics. Am J Gastroenterol 2019 Oct;114(10):1587-1592.
38. Soares RLS. Irritable bowel syndrome, food intolerance and non- celiac gluten sensitivity. A new clinical challenge. Arq Gastroenterol 2018 Oct-Dec;55(4):417-422
39. Catassi C, Alaedini A, Bojarski C, et al. The overlapping area of non-celiac gluten sensitivity (NCGS) and wheat-sensitive irritable bowel syndrome (IBS): an update. Nutrients 2017 Nov 21;9(11):1268.