Characterization of Ovarian Granulosa Cell Tumors using Magnetic Resonance Imaging

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Pamela Causa Andrieu Refky Nicola Federico Lipsich Daniel Adri Mariaangeles Gomez Melina Pol Alejandra Wernicke Gabriel Saraniti Carolina Chacon

Abstract

Purpose: To identify the MRI features that aid in the characterization of ovarian granulosa cell tumors.


Materials and methods: 11 MR pelvis of an adult woman with pathology-proven ovarian granulosa cell tumors with surgical pathology.


We evaluated the patient's age, Ca-125, size, laterality, and with MRI features such as indirect signs (i.e., thickened endometrium > 0.9 cm), morphology (cystic, solid-cystic, or solid), subacute hemorrhage, T2 signal (low or intermediate-to-high), restricted diffusion (B values: 0, 50, 1000 sec/mm3/ADC), and dynamic enhancement (intense or similar to myometrium). Also, the presence of ascites, peritoneal implants, or adenopathy.


Results: The final cohort included 11 women with a surgical-pathological diagnosis of granulosa cell tumors. The median age was 52.4 years (range, 17-80). The Ca-125 level was with a median within normal limits. The median size was 9.4 cm. Most cases were unilateral (81.8%) and more frequent on the left (54.5%).


MRI Analysis: 36.4% had endometrial thickening. Ovarian granulosa cell tumors were polymorphous: cystic (54.6%), mixed solid-cystic (9.1%), and solid (36.3%). Most GC had intermediate to high signal on T2 (90.9%), restricted diffusion (81.8%), intense enhancement (81.8%), and 36.4% had intraparenchymal bleeding. 9.1% had associated implants/adenopathy/ ascites at diagnosis.


Conclusion: The MRI features characteristic of ovarian granulosa cell tumors were the polymorphous morphology, an intense enhancement to the myometrium, restricted diffusion, and the presence of intraparenchymal hemorrhage.

Keywords: Granulosa cell tumor of the ovary, magnetic resonance imaging, ovarian neoplasms, Neoplasms, Germ Cell, Embryonal

Article Details

How to Cite
CAUSA ANDRIEU, Pamela et al. Characterization of Ovarian Granulosa Cell Tumors using Magnetic Resonance Imaging. Medical Research Archives, [S.l.], v. 10, n. 6, june 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2813>. Date accessed: 03 mar. 2024. doi: https://doi.org/10.18103/mra.v10i6.2813.
Section
Research Articles

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