Castleman Disease: A Wide Spectrum of Thoracic Manifestations
Main Article Content
Abstract
Castleman’s disease is a benign lymphoproliferative disorder affecting both lymph nodes and extranodal loci. Castleman’s disease can occur in practically any part of the body, but it occurs mainly in the thorax (~70%) followed by the abdomen and pelvis, neck and axilla. Clinically, Castleman’s disease can be classified into a unicentric or multicentric form, depending on the number of lymph nodes involved, and histologically into a hyaline vascular variant, plasma cell, mixed cellular or plasmablastic variant. In this mini-review we briefly report and focus on all clinical thoracic manifestations of Castleman’s disease resuming for each of them the possible strategy of treatment.
Keywords:
Castleman disease, mediastinal mass, lymphoproliferative disorder, thorax disease, mediastinal disease, surgical therapy
Article Details
How to Cite
MANGIAMELI, Giuseppe et al.
Castleman Disease: A Wide Spectrum of Thoracic Manifestations.
Medical Research Archives, [S.l.], v. 10, n. 5, june 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2829>. Date accessed: 27 dec. 2024.
doi: https://doi.org/10.18103/mra.v10i5.2829.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Takhar RP. Intrathoracic Castleman's disease: "An important clinical mimicker". Lung India. 2017 Mar-Apr;34(2):197-199. doi: 10.4103/lungindia.lungindia_419_15. PMID: 28360475; PMCID: PMC5351369.
2. Wu D, Lim MS, Jaffe ES. Pathology of Castleman Disease. Hematol Oncol Clin North Am. 2018 Feb;32(1):37-52. doi: 10.1016/j.hoc.2017.09.004. PMID: 29157618.
3. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956 Jul-Aug;9(4):822-30. doi: 10.1002/1097-0142(195607/08)9:4<822::aid-cncr2820090430>3.0.co;2-4. PMID: 13356266.
4. Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr;255(4):677-84. doi: 10.1097/SLA.0b013e318249dcdc. PMID: 22367441.
5. Barua A, Vachlas K, Milton R, Thorpe JA. Castleman's disease - a diagnostic dilemma. J Cardiothorac Surg. 2014 Nov 28;9:170. doi: 10.1186/s13019-014-0170-0. PMID: 25431102; PMCID: PMC4255971.
6. Wojtyś M, Piekarska A, Kunc M, Ptaszyński K, Biernat W, Zaucha JM, et al. Clinicopathological comparison and therapeutic approach to Castleman disease-a case-based review. J Thorac Dis. 2019 Nov;11(11):4859-4874. doi: 10.21037/jtd.2019.10.73. PMID: 31903277; PMCID: PMC6940266.
7. Cervantes CE, Correa R. Castleman Disease: A Rare Condition with Endocrine Manifestations. Cureus. 2015 Nov 17;7(11):e380. doi: 10.7759/cureus.380. PMID: 26719823; PMCID: PMC4689570.
8. Tanaka O, Kiryu T, Hirose Y, Fujikake R, Sakurai K, Hoshi H. Chest wall Castleman's disease: CT and MRI findings. Radiat Med. 2006 Aug;24(7):529-33. doi: 10.1007/s11604-006-0063-9. PMID: 17058149.
9. McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology. 1998 Oct;209(1):221-8. doi: 10.1148/radiology.209.1.9769835. PMID: 9769835.
10. Moon WK, Im JG, Kim JS, Choi CG, Kim HC, Yeon KM, et al. Mediastinal Castleman disease: CT findings. J Comput Assist Tomogr. 1994 Jan-Feb;18(1):43-6. doi: 10.1097/00004728-199401000-00009. PMID: 8282881.
11. Parrot A, Bazelly B, Milleron BJ, Carette MF, Georges O, Akoun GM. Localisation thoracique inhabituelle d'une tumeur de Castleman. A propos d'une observation [Unusual thoracic localization of Castleman's tumor. Apropos of a case]. Rev Pneumol Clin. 1989;45(4):168-70. French. PMID: 2626630.
12. Fajgenbaum DC, Shilling D. Castleman Disease Pathogenesis. Hematol Oncol Clin North Am. 2018 Feb;32(1):11-21. doi: 10.1016/j.hoc.2017.09.002. PMID: 29157613.
13. El-Osta HE, Kurzrock R. Castleman's disease: from basic mechanisms to molecular therapeutics. Oncologist. 2011;16(4):497-511. doi: 10.1634/theoncologist.2010-0212. Epub 2011 Mar 25. PMID: 21441298; PMCID: PMC3228122.
14. van Rhee F, Stone K, Szmania S, Barlogie B, Singh Z. Castleman disease in the 21st century: an update on diagnosis, assessment, and therapy. Clin Adv Hematol Oncol. 2010 Jul;8(7):486-98. PMID: 20864917.
15. Lomas OC, Streetly M, Pratt G, Cavet J, Royston D, Schey S, et al.; British Society for Haematology (BSH) Committee. The management of Castleman disease. Br J Haematol. 2021 Nov;195(3):328-337. doi: 10.1111/bjh.17688. Epub 2021 Aug 2. PMID: 34340261.
16. Legras A, Tallet A, Didelot A, Cazes A, Danel C, Hin A, et al. Clinical and molecular characteristics of unicentric mediastinal Castleman disease. J Thorac Dis. 2018 Apr;10(4):2079-2088. doi: 10.21037/jtd.2018.03.159. PMID: 29850111; PMCID: PMC5949489.
17. Biçakçioğlu P, Gülhan SŞ, Acar LN, Ağaçkiran Y, Özkara Ş, Kaya S, et al. Intrathoracic Castleman disease. Turk J Med Sci. 2014;44(2):197-202. doi: 10.3906/sag-1304-38. PMID: 25536724.
18. Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr;255(4):677-84. doi: 10.1097/SLA.0b013e318249dcdc. PMID: 22367441.
19. Iyoda A, Yusa T, Hiroshima K, Fujisawa T, Ohwada H. Castleman's disease in the posterior mediastinum: report of a case. Surg Today. 2000;30(5):473-6. doi: 10.1007/s005950050629. PMID: 10819491.
20. Ma W, Li J, Zhang L. A case of idiopathic multicentric Castleman disease presenting with diffuse lung cysts: how to evaluate treatment response? Ann Hematol. 2020 Jun;99(6):1401-1402. doi: 10.1007/s00277-020-04030-5. Epub 2020 May 7. PMID: 32382769.
21. Huang H, Feng R, Li J, Song X, Li S, Xu K, et al. Castleman disease-associated diffuse parenchymal lung disease: A STROBE-compliant retrospective observational analysis of 22 cases in a tertiary Chinese hospital. Medicine (Baltimore). 2017 Sep;96(39):e8173. doi: 10.1097/MD.0000000000008173. PMID: 28953671; PMCID: PMC5626314.
22. Yue B, Huang J, Jing L, Yu H, Wei D, Zhang J, et al. Bilateral lung transplantation for Castleman disease with end-stage bronchiolitis obliterans. Clin Transplant. 2022 Jan;36(1):e14496. doi: 10.1111/ctr.14496. Epub 2021 Oct 21. PMID: 34590355.
23. Peng M, Shi J, Feng R. Multicentric Castleman Disease as a Rare Cause of Diffuse Lung Cysts. Am J Respir Crit Care Med. 2020 May 15;201(10):1292-1293. doi: 10.1164/rccm.201905-1067IM. PMID: 31914318.
24. Tanaka O, Kiryu T, Hirose Y, Fujikake R, Sakurai K, Hoshi H. Chest wall Castleman's disease: CT and MRI findings. Radiat Med. 2006 Aug;24(7):529-33. doi: 10.1007/s11604-006-0063-9. PMID: 17058149.
25. Ueda H, Kouso H, Tsukamoto S. Castleman's disease of the chest wall. J Thorac Oncol. 2009 Mar;4(3):426-8. doi: 10.1097/JTO.0b013e3181989edc. PMID: 19247090.
26. Reynolds SP, Gibbs AR, Weeks R, Adams H, Davies BH. Massive pleural effusion: an unusual presentation of Castleman's disease. Eur Respir J. 1992 Oct;5(9):1150-3. PMID: 1426226.
27. Wilkinson S, Forrester-Wood CP. Surgical resection of a solitary plasmacytoma originating in a rib of a patient with Castleman's disease. Ann Thorac Surg. 2003 Mar;75(3):1018-9. doi: 10.1016/s0003-4975(02)04476-4. PMID: 12645741.
28. Eloueriachi F, Caidi M, Zouaidia F, Ouchen F, Maidi M, Fennane H, et al. Maladie de Castleman: localisation inhabituelle du thorax [Castleman disease: unusual location of the chest]. Pan Afr Med J. 2012;12:111. French. Epub 2012 Aug 22. PMID: 23133711; PMCID: PMC3489394.
29. Rena O, Casadio C, Maggi G. Castleman's disease: unusual intrathoracic localization. Eur J Cardiothorac Surg. 2001 Apr;19(4):519-21. doi: 10.1016/s1010-7940(01)00613-3. PMID: 11306326.
30. Testori A, Voulaz E, Alloisio M, Errico V, Cariboni U, De Simone M, Cioffi U. Multicentric castleman's disease resembling metastatic lung carcinoma. A case report. Clin Case Rep. 2018 Jan 22;6(3):473-475. doi: 10.1002/ccr3.1381. PMID: 29531720; PMCID: PMC5838266.
31. Chan KL, Lade S, Prince HM, Harrison SJ. Update and new approaches in the treatment of Castleman disease. J Blood Med. 2016 Aug 3;7:145-58. doi: 10.2147/JBM.S60514. PMID: 27536166; PMCID: PMC4976903.
2. Wu D, Lim MS, Jaffe ES. Pathology of Castleman Disease. Hematol Oncol Clin North Am. 2018 Feb;32(1):37-52. doi: 10.1016/j.hoc.2017.09.004. PMID: 29157618.
3. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956 Jul-Aug;9(4):822-30. doi: 10.1002/1097-0142(195607/08)9:4<822::aid-cncr2820090430>3.0.co;2-4. PMID: 13356266.
4. Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr;255(4):677-84. doi: 10.1097/SLA.0b013e318249dcdc. PMID: 22367441.
5. Barua A, Vachlas K, Milton R, Thorpe JA. Castleman's disease - a diagnostic dilemma. J Cardiothorac Surg. 2014 Nov 28;9:170. doi: 10.1186/s13019-014-0170-0. PMID: 25431102; PMCID: PMC4255971.
6. Wojtyś M, Piekarska A, Kunc M, Ptaszyński K, Biernat W, Zaucha JM, et al. Clinicopathological comparison and therapeutic approach to Castleman disease-a case-based review. J Thorac Dis. 2019 Nov;11(11):4859-4874. doi: 10.21037/jtd.2019.10.73. PMID: 31903277; PMCID: PMC6940266.
7. Cervantes CE, Correa R. Castleman Disease: A Rare Condition with Endocrine Manifestations. Cureus. 2015 Nov 17;7(11):e380. doi: 10.7759/cureus.380. PMID: 26719823; PMCID: PMC4689570.
8. Tanaka O, Kiryu T, Hirose Y, Fujikake R, Sakurai K, Hoshi H. Chest wall Castleman's disease: CT and MRI findings. Radiat Med. 2006 Aug;24(7):529-33. doi: 10.1007/s11604-006-0063-9. PMID: 17058149.
9. McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology. 1998 Oct;209(1):221-8. doi: 10.1148/radiology.209.1.9769835. PMID: 9769835.
10. Moon WK, Im JG, Kim JS, Choi CG, Kim HC, Yeon KM, et al. Mediastinal Castleman disease: CT findings. J Comput Assist Tomogr. 1994 Jan-Feb;18(1):43-6. doi: 10.1097/00004728-199401000-00009. PMID: 8282881.
11. Parrot A, Bazelly B, Milleron BJ, Carette MF, Georges O, Akoun GM. Localisation thoracique inhabituelle d'une tumeur de Castleman. A propos d'une observation [Unusual thoracic localization of Castleman's tumor. Apropos of a case]. Rev Pneumol Clin. 1989;45(4):168-70. French. PMID: 2626630.
12. Fajgenbaum DC, Shilling D. Castleman Disease Pathogenesis. Hematol Oncol Clin North Am. 2018 Feb;32(1):11-21. doi: 10.1016/j.hoc.2017.09.002. PMID: 29157613.
13. El-Osta HE, Kurzrock R. Castleman's disease: from basic mechanisms to molecular therapeutics. Oncologist. 2011;16(4):497-511. doi: 10.1634/theoncologist.2010-0212. Epub 2011 Mar 25. PMID: 21441298; PMCID: PMC3228122.
14. van Rhee F, Stone K, Szmania S, Barlogie B, Singh Z. Castleman disease in the 21st century: an update on diagnosis, assessment, and therapy. Clin Adv Hematol Oncol. 2010 Jul;8(7):486-98. PMID: 20864917.
15. Lomas OC, Streetly M, Pratt G, Cavet J, Royston D, Schey S, et al.; British Society for Haematology (BSH) Committee. The management of Castleman disease. Br J Haematol. 2021 Nov;195(3):328-337. doi: 10.1111/bjh.17688. Epub 2021 Aug 2. PMID: 34340261.
16. Legras A, Tallet A, Didelot A, Cazes A, Danel C, Hin A, et al. Clinical and molecular characteristics of unicentric mediastinal Castleman disease. J Thorac Dis. 2018 Apr;10(4):2079-2088. doi: 10.21037/jtd.2018.03.159. PMID: 29850111; PMCID: PMC5949489.
17. Biçakçioğlu P, Gülhan SŞ, Acar LN, Ağaçkiran Y, Özkara Ş, Kaya S, et al. Intrathoracic Castleman disease. Turk J Med Sci. 2014;44(2):197-202. doi: 10.3906/sag-1304-38. PMID: 25536724.
18. Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr;255(4):677-84. doi: 10.1097/SLA.0b013e318249dcdc. PMID: 22367441.
19. Iyoda A, Yusa T, Hiroshima K, Fujisawa T, Ohwada H. Castleman's disease in the posterior mediastinum: report of a case. Surg Today. 2000;30(5):473-6. doi: 10.1007/s005950050629. PMID: 10819491.
20. Ma W, Li J, Zhang L. A case of idiopathic multicentric Castleman disease presenting with diffuse lung cysts: how to evaluate treatment response? Ann Hematol. 2020 Jun;99(6):1401-1402. doi: 10.1007/s00277-020-04030-5. Epub 2020 May 7. PMID: 32382769.
21. Huang H, Feng R, Li J, Song X, Li S, Xu K, et al. Castleman disease-associated diffuse parenchymal lung disease: A STROBE-compliant retrospective observational analysis of 22 cases in a tertiary Chinese hospital. Medicine (Baltimore). 2017 Sep;96(39):e8173. doi: 10.1097/MD.0000000000008173. PMID: 28953671; PMCID: PMC5626314.
22. Yue B, Huang J, Jing L, Yu H, Wei D, Zhang J, et al. Bilateral lung transplantation for Castleman disease with end-stage bronchiolitis obliterans. Clin Transplant. 2022 Jan;36(1):e14496. doi: 10.1111/ctr.14496. Epub 2021 Oct 21. PMID: 34590355.
23. Peng M, Shi J, Feng R. Multicentric Castleman Disease as a Rare Cause of Diffuse Lung Cysts. Am J Respir Crit Care Med. 2020 May 15;201(10):1292-1293. doi: 10.1164/rccm.201905-1067IM. PMID: 31914318.
24. Tanaka O, Kiryu T, Hirose Y, Fujikake R, Sakurai K, Hoshi H. Chest wall Castleman's disease: CT and MRI findings. Radiat Med. 2006 Aug;24(7):529-33. doi: 10.1007/s11604-006-0063-9. PMID: 17058149.
25. Ueda H, Kouso H, Tsukamoto S. Castleman's disease of the chest wall. J Thorac Oncol. 2009 Mar;4(3):426-8. doi: 10.1097/JTO.0b013e3181989edc. PMID: 19247090.
26. Reynolds SP, Gibbs AR, Weeks R, Adams H, Davies BH. Massive pleural effusion: an unusual presentation of Castleman's disease. Eur Respir J. 1992 Oct;5(9):1150-3. PMID: 1426226.
27. Wilkinson S, Forrester-Wood CP. Surgical resection of a solitary plasmacytoma originating in a rib of a patient with Castleman's disease. Ann Thorac Surg. 2003 Mar;75(3):1018-9. doi: 10.1016/s0003-4975(02)04476-4. PMID: 12645741.
28. Eloueriachi F, Caidi M, Zouaidia F, Ouchen F, Maidi M, Fennane H, et al. Maladie de Castleman: localisation inhabituelle du thorax [Castleman disease: unusual location of the chest]. Pan Afr Med J. 2012;12:111. French. Epub 2012 Aug 22. PMID: 23133711; PMCID: PMC3489394.
29. Rena O, Casadio C, Maggi G. Castleman's disease: unusual intrathoracic localization. Eur J Cardiothorac Surg. 2001 Apr;19(4):519-21. doi: 10.1016/s1010-7940(01)00613-3. PMID: 11306326.
30. Testori A, Voulaz E, Alloisio M, Errico V, Cariboni U, De Simone M, Cioffi U. Multicentric castleman's disease resembling metastatic lung carcinoma. A case report. Clin Case Rep. 2018 Jan 22;6(3):473-475. doi: 10.1002/ccr3.1381. PMID: 29531720; PMCID: PMC5838266.
31. Chan KL, Lade S, Prince HM, Harrison SJ. Update and new approaches in the treatment of Castleman disease. J Blood Med. 2016 Aug 3;7:145-58. doi: 10.2147/JBM.S60514. PMID: 27536166; PMCID: PMC4976903.