Elevated D-dimer is associated with severity of COVID-19: A systematic review and meta-analysis Elevated D-dimer with severity of COVID-19:

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Published Jul 31, 2022
DOI: https://doi.org/10.18103/mra.v10i7.2870

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Main Article Content

Hasna Jahan, MBBS
MPhil fellow, Institute of Environmental Science, University of Rajshahi
Tanzima Yeasmin, PhD
Professor and Chairman, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Molay Roy, PhD
Former Research Fellow atNational Agricultural Research Organization, Tsukuba, Japan, & University of Guelph, Ontario, Canada.

Abstract

With the rapid increase of COVID-19 cases, identifying case severity has become a critical issue for hospital admission and intensive care treatment. Given that pre-existing comorbidities play a significant role in the severity, emerging evidence indicates coagulopathy becomes an independent condition that causes respiratory distress in COVID-19.


In this metanalysis, relevant literatures reporting D-dimer, a coagulation byproduct, in COVID-19 cases were synthesized and statistically analyzed to test if the D-dimer level can predict case severity and mortality.


The analysis found that D-dimer levels were higher in non-survivors/severe than in survivors/non-severe, (MD 0.64, 95% CI 0.52 to 0.75; participants = 5957, I2 = 98%). Subgroup analysis showed MD between non-survivors and survivors was MD 3.48 μg/mL (95% CI 2.69 to 4.27; participants = 1799; studies = 7; I2 = 86%) with Z-score 8.64, p<0.0001. In meta-regression, a significant correlation was observed between increased plasma mean D-dimer level with increased proportion case severity (P=0.046) and mortality (P=0.009).


Overall, the study found that the D-dimer level index can be a predictor of risk for case severity and mortality in COVID-19 patients. The test is rapid and inexpensive and can help clinicians prioritize medical care other than deciding therapeutic options for clinical goals.

Keywords: COVID-19, SARS-CoV-2, D-dimer, Coagulopathy, Risk, Management, Systematic Review, Meta-Analysis

Article Details

How to Cite
JAHAN, Hasna; YEASMIN, Tanzima; ROY, Molay. Elevated D-dimer is associated with severity of COVID-19: A systematic review and meta-analysis. Medical Research Archives, [S.l.], v. 10, n. 7, july 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2870>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.18103/mra.v10i7.2870.
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Issue
Vol 10 No 7 (2022): Vol.10 Issue 7 July 2022
Section
Review Articles

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