The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies
Main Article Content
Abstract
Osteoarthritis (OA) is a joint disorder characterized by chronic, degenerative, and irreversible inflammation leading to pain and disability. The standard drugs are ineffective for many patients and are usually associated with numerous side effects such as gastrointestinal complaints. Curcuma longa and its bioactive compounds have been considered for OA. The objective of this study was to perform a systematic review of the effects of Curcuma longa and its derivatives on OA. Pubmed, Cochrane, and Embase were searched, and PRISMA guidelines were followed to build this review. Only Randomized Clinical Trials (RCTs) that performed placebo-comparison were included. Most included studies showed that Curcuma longa or formulations prepared with curcuminoids can benefit the OA scores such as Visual Analog Scale, Knee injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Osteoarthritis Index; and Lequesne's pain functional index. The use of Curcuma longa extracts or curcuminoids can benefit patients with OA. Nevertheless, the available RCTs show treatment time, doses, and formulations heterogeneity. Thus, the standardization of RCTs can guide researchers and physicians on the dosages and formulations that are most effective in addressing this condition, which is very prevalent in the world's populations.
Keywords:
Curcuma longa, curcuminoids, curcumin, arthritis, Osteoarthritis
Article Details
How to Cite
ALVARENGA, Luiz Henrique et al.
The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies.
Medical Research Archives, [S.l.], v. 10, n. 6, june 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2888>. Date accessed: 24 apr. 2024.
doi: https://doi.org/10.18103/mra.v10i6.2888.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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2. Akuri MC, Barbalho SM, Val RM, Guiguer EL. Reflections about Osteoarthritis and Curcuma longa. Pharmacognosy reviews. 2017;11(21):8-12.
3. Gallotti FCM, Serafini MR, Thomazzi SM. Scenario of the Treatments of Arthritis with Natural Products. Recent Pat Inflamm Allergy Drug Discov. 2020.
4. Araya-Quintanilla F, Gutierrez-Espinoza H, Munoz-Yanez MJ, Sanchez-Montoya U, Lopez-Jeldes J. Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-Analysis. Pain physician. 2020;23(2):E151-e161.
5. Bruce DJ, Hassaballa M, Robinson JR, Porteous AJ, Murray JR, Newman JH. Minimum 10-year outcomes of a fixed bearing all-polyethylene unicompartmental knee arthroplasty used to treat medial Osteoarthritis. Knee. 2020.
6. Loo SJQ, Wong NK. Advantages and challenges of stem cell therapy for Osteoarthritis (Review). Biomedical reports. 2021;15(2):67.
7. Riegger J, Brenner REJIjoms. Pathomechanisms of posttraumatic Osteoarthritis: chondrocyte behavior and fate in a precarious environment. 2020;21(5):1560.
8. Chow YY, Chin KY. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of inflammation. 2020;2020:8293921.
9. Schulze-Tanzil GJJoEP. Experimental Therapeutics for the Treatment of Osteoarthritis. 2021;13:101.
10. Schulze-Tanzil G. Experimental Therapeutics for the Treatment of Osteoarthritis. Journal of experimental pharmacology. 2021;13:101-125.
11. McLarnon M, Heron N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC musculoskeletal disorders. 2021;22(1):550.
12. Marton LT, Barbalho SM, Sloan KP, et al. curcumin, autoimmune and inflammatory diseases: going beyond conventional therapy - a systematic review. Critical reviews in food science and nutrition. 2020:1-19.
13. Valsamidou E, Gioxari A, Amerikanou C, Zoumpoulakis P, Skarpas G, Kaliora AC. Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies. Nutrients. 2021;13(5).
14. Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC complementary medicine and therapies. 2020;20(1):225.
15. Bowden JL, Kobayashi S, Hunter DJ, et al. Best-practice clinical management of flares in people with Osteoarthritis: A scoping review of behavioral, lifestyle and adjunctive treatments. Seminars in arthritis and rheumatism. 2021;51(4):749-760.
16. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of internal medicine. 2009;151(4):264-269, w264.
17. Higgins JP, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons; 2019.
18. Pinsornsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thai. 2012;95 Suppl 1:S51-58.
19. Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013;21(2):129-136.
20. Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. J Diet Suppl. 2016;13(2):209-220.
21. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytotherapy research : PTR. 2014;28(11):1625-1631.
22. Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2014;19(6):933-939.
23. Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial. Drug research. 2015;65(10):521-525.
24. Sterzi S, Giordani L, Morrone M, et al. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study. European journal of physical and rehabilitation medicine. 2016;52(3):321-330.
25. Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RS. Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in Osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology. 2016;24(6):377-388.
26. Haroyan A, Mukuchyan V, Mkrtchyan N, et al. Efficacy and safety of curcumin and its combination with boswellic acid in Osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC complementary and alternative medicine. 2018;18(1):7.
27. Panda SK, Nirvanashetty S, Parachur VA, Mohanty N, Swain T. A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene(R) versus Placebo in Reducing Symptoms of Knee OA. BioMed research international. 2018;2018:5291945.
28. Gupte PA, Giramkar SA, Harke SM, et al. Evaluation of the efficacy and safety of Capsule Longvida((R)) Optimized curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. J Inflamm Res. 2019;12:145-152.
29. Henrotin Y, Malaise M, Wittoek R, et al. Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther. 2019;21(1):179.
30. Calderón-Pérez L, Llauradó E, Companys J, et al. Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial. Journal of medicinal food. 2021;24(4):436-440.
31. Wang Z, Jones G, Winzenberg T, et al. Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Annals of internal medicine. 2020;173(11):861-869.
32. Shep D, Khanwelkar C, Gade P, Karad S. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. 2019;20(1):214.
33. Dosoky NS, Setzer WN. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. Nutrients. 2018;10(9).
34. Kocaadam B, Sanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical reviews in food science and nutrition. 2017;57(13):2889-2895.
35. Ayati Z, Ramezani M, Amiri MS, et al. Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review. Current pharmaceutical design. 2019;25(8):871-935.
36. Mazieiro R, Frizon RR, Barbalho SM, Goulart RA. Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases? Journal of medicinal food. 2018;21(11):1077-1085.
37. Marton LT, Pescinini ESLM, Camargo MEC, et al. The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Frontiers in endocrinology. 2021;12:669448.
38. Yuandani, Jantan I, Rohani AS, Sumantri IB. Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review. Frontiers in pharmacology. 2021;12:643119.
39. Cunha Neto F, Marton LT, de Marqui SV, Lima TA, Barbalho SMJCrifs, nutrition. Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis? 2019;59(13):2136-2143.
40. Goulart RdA, Barbalho SM, Lima VM, et al. Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review. 2020.
41. Seo EJ, Fischer N, Efferth T. Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease. Pharmacological research. 2018;129:262-273.
42. Cunha Neto F, Marton LT, de Marqui SV, Lima TA, Barbalho SM. Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis? Critical reviews in food science and nutrition. 2019;59(13):2136-2143.
43. Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V, Fayad R. Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations. Food & function. 2012;3(11):1109-1117.
44. Soleimani V, Sahebkar A, Hosseinzadeh HJPR. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances. 2018;32(6):985-995.
45. Goulart RdA, Barbalho SM, Rubira CJ, et al. Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis. 2020;14(12):1171-1179.
46. Jang S, Lee K, Ju JH. Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. International journal of molecular sciences. 2021;22(5).
47. Ansari MY, Ball HC, Wase SJ, Novak K, Haqqi TM. Lysosomal dysfunction in Osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c. Osteoarthritis and cartilage. 2021;29(1):100-112.
48. Miller RE, Scanzello CR, Malfait AM. An emerging role for Toll-like receptors at the neuroimmune interface in Osteoarthritis. Seminars in immunopathology. 2019;41(5):583-594.
49. Di Nicola V. Degenerative osteoarthritis a reversible chronic disease. Regenerative therapy. 2020;15:149-160.
50. Fu YB, Chen JW, Li B, Yuan F, Sun JQ. [Effect of fire needling on mild to moderate knee osteoarthritis and related serum inflammatory cytokines]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2021;41(5):493-497.
51. Zhang L, Xing R, Huang Z, et al. Synovial Fibrosis Involvement in Osteoarthritis. Frontiers in medicine. 2021;8:684389.
52. Vincent TL. Mechanoflammation in osteoarthritis pathogenesis. Seminars in arthritis and rheumatism. 2019;49(3s):S36-s38.
53. Ismail HM, Didangelos A, Vincent TL, Saklatvala JJA, Rheumatology. Rapid Activation of Transforming Growth Factor β–Activated Kinase 1 in Chondrocytes by Phosphorylation and K63‐Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. 2017;69(3):565-575.
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