The Neglected Second Mechanism of Pathogenicity in Crohn’s disease: Infectious Diseases Incorporated’s Perspective
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Abstract
Crohn’s disease is an immune-mediated disease which results from the persistence of a pro-inflammatory cytokine response to Mycobacterium avium subspecies paratuberculosis (MAP) and MAPs widespread presence in the food supply of industrialized nations. Over time, the destructive antigen/cytokine interaction overwhelms the regenerative capacity of the gastrointestinal mucosa. The resultant focal destruction of mucosal integrity creates a portal for invasion by the gastrointestinal microbiota; the second mechanism of pathogenicity for Crohn’s disease. Failure to effectively address polymicrobial submucosal infections has resulted in 25% of Crohn’s afflicted individuals requiring one or more operations within their lifetimes.
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References
2. Millar, D. Ford, J. Sanderson, J. et al. 1996. IS 900 PCR to detect Mycobacterium avium subspecies paratuberculosis in retail supplies of whole pasteurized milk in England and Wales. Appl. Environ Microbiol. 62:3446-54
3. Grant I. R., Ball H. J., Neill S. D., Rowe M. T. 1996. Inactivation of Mycobacterium paratuberculosis in cow’s milk at pasteurization temperatures. Appl. Environ. Microbiol. 62:631-636
4. Millar, D. Ford, J. Sanderson, J. et al. 1996. IS 900 PCR to detect Mycobacterium avium subspecies paratuberculosis in retail supplies of whole pasteurized milk in England and Wales. Appl. Environ Microbiol. 62:3446-54
5. Grant I. R., Ball H. J., Neill S. D., Rowe M. T. 1996. Inactivation of Mycobacterium paratuberculosis in cow’s milk at pasteurization temperatures. Appl. Environ. Microbiol. 62:631-636
6. Hruska K., Barto M., Kralik P., Pavilik P. 2005. Mycobacterium avium subsp. paratuberculosis in powdered infant milk: paratuberculosis in cattle – public health problem to be solved. Veterinarni Medicina 2005:327-335 http://vri.cs/dos/vetmed/56-5-226.pdf
7. Botsaris G., Swift B. M. C., Slama J. et al. 2016. Detection of viable Mycobacterium avium subspecies paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture. Intern. J. Food Microbiol. 216:91-94
8. Monif G. R. G. 2017. An infectious disease process within an immune-mediated disease process: Role of the gastrointestinal microbiota in Crohn’s disease. Adv. Res. Gastroenterol. Hepatol. 5 (5):1-2 doi.10.19080/ARGH 2017.05555675
9. Monif G. R. G. 2018. Are the permanent sequelae of Crohn’s disease a failure to treat the gastrointestinal microbiota. Med. Hypothesis. 122:198-199
10. Gorbach S. L., Bartlett J. C.1974. Anaerobic infections. N. Engl. J. Med. 290:1280-1294
11. Schleig P. M., Buergelt C. D., Davis J. K. et al. 2005. Attachment of Mycobacterium avium subspecies paratuberculosis to bovine intestinal organ cultures: method of development and strain differences. Vet. Microbiol. 108:271-279
12. Gorbach S. l.: 199. Clinical aspects of anaerobic infections. J. Infect. 1:25s-37
13. Monif G. R. G. 2019. Is ulcerative colitis a disease of a dysfunctional microbiota Med. Hypothesis 131 (2019) 199300. Doi.org/10.1016/j.mehy.2019.1009300
14. Lichenstein G. R., Loftus E. V. Jr., Isaacs K. I. et al. 2018. ACG Clinical Guidelines: Management of Crohn’s disease in adults. Am. J. gastroenterol. 113:481-517. Doi 10,1038.ajg.2018.27
15. Monif G. R. G. 2021. The Crohn’s disease: The Infectious Disease Incorporated’s Perspective. Gastrointest. Discord. 2021 3:138-141, doi.org/10.3390/gdiscord3030015
16. Monif G. R. G. 022. Crohn’s disease: A curable disease held hostage? Chapter20. eBook ISBN: 978-93-5547-537-4 20