The Neglected Second Mechanism of Pathogenicity in Crohn’s disease: Infectious Diseases Incorporated’s Perspective

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Gilles R. G. Monif, M.D.

Abstract

Crohn’s disease is an immune-mediated disease which results from the persistence of a pro-inflammatory cytokine response to Mycobacterium avium subspecies paratuberculosis (MAP) and MAPs widespread presence in the food supply of industrialized nations. Over time, the destructive antigen/cytokine interaction overwhelms the regenerative capacity of the gastrointestinal mucosa. The resultant focal destruction of mucosal integrity creates a portal for invasion by the gastrointestinal microbiota; the second mechanism of pathogenicity for Crohn’s disease. Failure to effectively address polymicrobial submucosal infections has resulted in 25% of Crohn’s afflicted individuals requiring one or more operations within their lifetimes.

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How to Cite
MONIF, Gilles R. G.. The Neglected Second Mechanism of Pathogenicity in Crohn’s disease: Infectious Diseases Incorporated’s Perspective. Medical Research Archives, [S.l.], v. 10, n. 6, june 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2889>. Date accessed: 20 apr. 2024. doi: https://doi.org/10.18103/mra.v10i6.2889.
Section
Research Articles

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