Abstract
Introduction; Multi-system inflammatory syndrome (MIS) is a para infectious or post infectious extra-pulmonary complication of COVID-19. Neurological complications are better described in children with multi-system inflammatory syndrome (MIS) in children (MIS-C). There is a paucity of literature about severe neurological manifestations of multi-system inflammatory syndrome in adults (MIS-A).
Methods; Over a 22-month period, from June 2020 to December 2021, over 3450 COVID patients were admitted to our institution including 900 patients in the medical and COVID ICUs. Ten patients (1.1%) presented to us with MIS-A with severe neurological manifestations.
Results; Severe neurological manifestations included transverse myelitis, COVID encephalitis, acute encephalopathy, status epilepticus and rhabdomyolytic myopathy. Our cohort had a high morbidity and mortality rate.
Conclusions; Most patients with MIS-A had severe neurological involvement and a poor outcome.