Severe Neurological Manifestations of Multisystem Inflammatory Syndrome in Adults (MIS-A)

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Boby Varkey Maramattom, MD,DM, FRCP, FRCPE, FICCN


Introduction; Multi-system inflammatory syndrome (MIS) is a para infectious or post infectious extra-pulmonary complication of COVID-19. Neurological complications are better described in children with multi-system inflammatory syndrome (MIS) in children (MIS-C). There is a paucity of literature about severe neurological manifestations of multi-system inflammatory syndrome in adults (MIS-A).

Methods; Over a 22-month period, from June 2020 to December 2021, over 3450 COVID patients were admitted to our institution including 900 patients in the medical and COVID ICUs. Ten patients (1.1%) presented to us with MIS-A with severe neurological manifestations.

Results; Severe neurological manifestations included transverse myelitis, COVID encephalitis, acute encephalopathy, status epilepticus and rhabdomyolytic myopathy. Our cohort had a high morbidity and mortality rate.

Conclusions; Most patients with MIS-A had severe neurological involvement and a poor outcome.

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How to Cite
MARAMATTOM, Boby Varkey. Severe Neurological Manifestations of Multisystem Inflammatory Syndrome in Adults (MIS-A). Medical Research Archives, [S.l.], v. 10, n. 7, july 2022. ISSN 2375-1924. Available at: <>. Date accessed: 08 aug. 2022. doi:
Research Articles


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