A New Approach to Tumor Cancer with a Novel Imaging Profile for White matter abnormalities including Leukodystrophies: Sensing the Human Brain
Main Article Content
Neuromolecular Imaging (NMI) for white matter detection, distinct from that of gray matter is an inventive art. (1) This imaging technique demonstrates, for the first time, a LIVE and continuous videotracking nanotechnology for distinguishing white matter from gray matter in the brain of epilepsy patients, online, in real time and for long periods of time. NMI is known to perform with unrivaled temporal and spatial operational reliability and reproducibility Thus, a nanotechnology for white matter disorders, for example, leukodystrophies, is published for the first time. The purpose of this paper is to present a critical distinction for white versus gray matter in hippocampal and neocortical resected tissue derived from mesial and neocortical temporal lobe epilepsy patients en bloc during intraoperative surgery; the patients present as medically refractory to classical pharmacotherapeutics. The tiny carbon-based lipid polymeric sensor, the BRODERICK PROBE® readily sees white matter in contrast to gray matter in brain neuroanatomic substrates as it continually senses the glia or the neuron, white or gray matter, respectively, with distinct clarity via electroactive signal processing. The difference between white and gray matter is striking as the videotrace slides smoothly from the white to the gray milieu. Thus, a primary in vivo white matter nanotechnology is presented to advance diagnosis and therapy for white and gray matter abnormalities in the brain and spinal cord.
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
2. Broderick PA, Pacia SV, Doyle WK, Devinsky O. Monoamine neurotransmitters in resected hippocampal subparcellations from neocortical and mesial temporal lobe epilepsy patients: In situ microvoltammetry. Br. Res. 2000:878: 48-63
3. Pacia SV, Doyle WK, Broderick PA, Biogenic amines in resected human neocortex in patients with neocortical and mesial temporal lobe epilepsy: Identification with in situ microvoltammetry. Br. Res. 2001: 899: 106-111
4. Broderick PA, Doyle WK, Pacia SV, Kuzniecky RI, Devinsky O, Kolodny EH Conference Paper, Intraoperative Neuromolecular Imaging (NMI) in Comparison with Resected Epileptogenic Tissue. 2009: Society for Neuroscience, Nov.
5. Broderick PA. Studies of oxidative stress mechanism using a morphine/ascorbate animal model and novel N-stearoyl cerebroside and laurate sensors. J. Neural Transm. 2008:115(1):7-17. DOI: 10.1007/s00702-007-0809-2
6. Broderick PA, Wenning L Neuromolecular Imaging and BRODERICK PROBE® nanobiosensors reveal a temporal synchrony in brain rhythms in neural transmission online with movement designs during natural physiology: Temporal asynchrony is imaged online in the same subject during pathology. Med. Res. Archives 2018:vol.6, July DOI: https://doi.org/10.18103/mra.v6i8.1765.
7. Kissinger PT, Preddy CR, Shoup RE, Heineman WR. Fundamental Concepts of Analytical Electrochemistry. In: Kissinger PT, Heineman WR (eds.) Laboratory Techniques in Electroanalytical Chemistry, 1984, Marcell Dekker Inc.: New York, pp 9-49
8. Broderick PA. In vivo voltammetric studies on release mechanisms for cocaine with gammabutyrolactone. Pharmacol Biochem Behav.1991:40:969–975
9. Broderick PA Striatal neurochemistry of dynorphin-(1-13): in vivo electrochemical semidifferential analyses. Neuropeptides 1987:10: 369-86
10. Broderick PA, Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin. Brain Res. 1989:495: 115-21
11. Broderick PA Distinguishing in vitro electrochemical signatures for norepinephrine and dopamine. Neurosci. Lett. 1988:95: 275-80
12. Roceanu A, Onu M, Antochi F, Bajenaru O. Diffusion Tensor Imaging (DTI) - A New Imaging Technique Applied in Multiple Sclerosis. Maedica (Bucur). 2012: Dec; 7(4): 355–357
13. Broderick PA et al. (2021) Identification, Diagnosis, and Treatment of Neuropathologies, Neurotoxicities, Tumors, and Brain and Spinal Cord Injuries Using Electrodes with Microvoltammetry. US Patent Serial No. 10,980,460, April 20th, 2021, Issued.
14. Broderick PA (2021) Noninvasive Electroactive Photonic Protein Sensor with Polymer Photovoltaic Optics for Memory Transduction using Organic and Inorganic Elements as Platforms. US Non-Provisional Patent. International Application Patent # PCT/US16/68879. US Serial No. 11,197,615, B2, December 14th, 2021, Issued.
15. Broderick PA., (2022) Neuroimaging: Nanosensing Biochemistry in the Brain, An Imaging Textbook- The evolution of In Vivo Electrochemistry into Neuromolecular Imaging into NonInvasive Voltaic Photonics: LIVE IMAGING, Pan Stanford Publishing Pte Ltd., Singapore. In Press