Study of Outcome After One Year Follow Up of Tuberculosis Patients After the Completion of Treatment in Tertiary Care Center in Western Maharashtra

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Kiran Kumar Kompella, Dr Someshwar Gaikwad, Dr Anuj Singhal, Prof Vishal Mangal, Dr Arun Kumar Yadav, Dr Saurav Kumar Chauhan, Dr

Abstract

Background: Tuberculosis (TB) still remains an important public health problem in India. After completion of treatment, we hardly know that what happened to these cases once they are declared as cured and released in community. Hence the study was conducted to find out the outcomes and factors associated with them.


Material and methods: It was a longitudinal observational study. Patients were followed up for up to one year after completion of the treatment for weight gain, and adverse side effects.


Results: In our study 91 % of the cases were cured, 1.7 % were treatment failure and 2.18 % died. All the cases of recurrent TB were cured. HIV and TB co-infection was found in 15.7 % cases. 85% of patients tolerated the anti-tubercular therapy (ATT) well. The incidence of extra pulmonary TB was 19.2 %. Out of 229 cases 16 failed to gain weight at the end of therapy. The gain in weight was statistically significant (p value <0.001). The adverse outcome was seen in 20 cases.


Conclusion: In our study, 91 % of the cases including 100% of recurrent Tb cases were cured because of newer RNTCP program. The incidence of extra pulmonary TB was higher than the national average. The majority (85%) of patients tolerated the anti-tubercular therapy (ATT) well. Out of 229 cases, only 16 patients failed to gain weight at the end of therapy. The gain in weight was significant predictor of good outcome in treating tuberculosis. The factors like weight gain, age, sex, place of stay or comorbidities were not associated as predictors of poor outcome. However, presence of co-morbidity like HIV and Diabetes may be associated with poor outcome but a higher sample size may be required to confirm it.


Key Message: This study highlighted the importance of weight gain after IP in tuberculosis patients on ATT. The extra pulmonary TB is far more common than national average.

Article Details

How to Cite
KOMPELLA, Kiran Kumar et al. Study of Outcome After One Year Follow Up of Tuberculosis Patients After the Completion of Treatment in Tertiary Care Center in Western Maharashtra. Medical Research Archives, [S.l.], v. 10, n. 8, aug. 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3004>. Date accessed: 28 sep. 2022. doi: https://doi.org/10.18103/mra.v10i8.3004.
Section
Case Reports

References

1. WHO. Global Tuberculosis Report 2019. [Internet]. Geneva,WHO, 2019; [cited 2020 Mar 30]. 297p. Available from https://apps.who.int/iris/bitstream/handle/10665/329368/9789241565714-eng.pdf?ua=1
2. WHO: Tuberculosis fact sheet. [Internet] WHO: 2020. [cited 2020 Mar 30] Available from https://www.who.int/en/news-room/fact-sheets/detail/tuberculosis
3. Global Tuberculosis Control: Surveillance, planning, financing. WHO Report 2010, World Health Organization, Geneva, Switzerland, 2010.
4. Corbett EL, Watt CJ, Walker N. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Archives of Internal Medi. 2003; 163(9):1009-21.
5. Dye C, Espinal MA, Watt CJ, Mbiaga C, Williams BG. Worldwide incidence of multidrug-resistant tuberculosis. J Infect Dis. 2002; 185(8):1197-1202.
6. Sharma R, Prajapati S, Patel P, Patel B, Gajjar S, Bapat N. An outcome-based follow-up study of cured category I Pulmonary Tuberculosis Adult Cases from Various Tuberculosis Units under Revised National Tuberculosis Control Program from a Western Indian City. Indian Journal of Community Medicine. 2019;44(1):48-52
7. Akarkar NS, Pradhan SS, Ferreira AM. Treatment outcomes among tuberculosis patients at an urban health centre, Goa, India: eight-year retrospective record based study. Int J Community Med Public Health. 2017; 4(3):831-34.
8. Chennaveerappa PK, Siddharam SM, Halesha BR, Vittal BG, Jayashree N. Treatment outcome of tuberculosis patients registered at DOTS centre in a teaching hospital, South India. Int J Biol Med Res. 2011; 2(2):487-9.
9. Okanurak K, Kitayapor D, Wanarangsikul W, Koompong C. Effectiveness of DOT for tuberculosis treatment outcome: a prospective study in Bangkok, Thailand.Int J Tuberc Lung disease. 2007; 11(7): 762-768.
10. Diel R, Niemann S. Outcome of tuberculosis treatment in Hamburg: a survey 1997-2001. Int J Tuberc Lung Dis. 2003; 7(2): 124-131.
11. Khan MA, Basit A, Ziaullah ,Javaid A. Outcome of tuberculosis patients registered during 2007 in major teaching hospitals of Peshawar. J. Postgrad. Med. Inst. 2009; 23(04):358-362.
12. Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare, New Delhi. RNTCP TB status Report. 2007; 1: 10-13.
13. Vasantha M, Gopi PG, Subramani R. Weight gain in patients with tuberculosis treated under DOTS. Indian J Tuberc. 2009; 56:5–9.
14. Kennedy N, Ramsay A, Uiso L, Gutmann J, Ngowi FI, Gillespie SH. Nutritional status and weight gain in patients with pulmonary tuberculosis in Tanzania. Trans R Soc Trop Med Hyg 1996; 90:162–6.
15. Mayer KH, Hamilton CD (2010) Synergistic Pandemics: Confronting the Global HIV and Tuberculosis Epidemics. Clinical Infect Dis 50: S67–S70.
16. Gebremariam G, Asmamaw G, Hussen M, Hailemariam MZ, Asegu D, Astatkie A, et al. (2016) Impact of HIV Status on Treatment Outcome of Tuberculosis Patients Registered at Arsi Negele Health Center, Southern Ethiopia: A Six Year Retrospective Study. PLoS ONE 11(4): e0153239. doi:10.1371/journal.pone.01532399
17. Moharana PR, Satapathy DM, Sahani NC. An analysis of treatment outcome among TB patients put under dots at a tertiary level health facility of Orissa. JComm Med. 2009; 5(2): 5-8.
18. Chadha SL, Bhagi RP. Treatment outcome in tuberculosis patients placed under directly observed treatment short course- A cohort study. Ind J Tub. 2000; 47:155-158.