The Role of Material Technologies Targeting P. Aeruginosa and S. Aureus Quorum Sensing in Biofilm Formation
Main Article Content
Abstract
Periprosthetic joint infections are a major complication after total joint arthroplasty. Pseudomonas aeruginosa and Staphylococcus aureus are of great clinical concern, due to high antibiotic resistance, which is even increased when they form a biofilm on the implant surface. In this qualitative systematic review based on the PRISMA statement, biofilm formation of S. aureus and P. aeruginosa was studied, with a particular emphasis on the role of quorum sensing (QS). Treatment of infection by these bacteria by regulation or inhibition of the QS system via material technology was also reviewed. Pubmed, Google Scholar and Embase were searched. Articles were selected on their titles and use of the English language. All abstracts of the remaining articles were judged on the quality of the article, and fit with the scope of the review. This led to a selection of 62 articles, which consisted of 29 research articles and 33 reviews. In P. aeruginosa different QS systems are present in a hierarchal structure. These QS systems play an important role for formation of virulence factors and polymeric substances used in biofilm formation. In S. aureus, QS regulates biofilm dispersal, but not biofilm formation. Different treatments, either preventative by inhibiting biofilm formation or curative by biofilm dispersal are described in the literature. Combinations of QS inhibitors (QSI) and either antibiotics or metallic (nano)particles showed most promise in biofilm inhibition. QSI’s and other biofilm inhibitors are only under preclinical investigation. Furthermore, QS has different functions in different bacteria, and treatment using QSI’s are not suitable for every infection. While this makes QSI therapy unfit as an alternative to antibiotics, QSI’s in combination with antibiotics can be a potent strategy to prevent biofilm formation.
Keywords:
quorum sensing, biofilm, material technology, Pseudomonas aeruginosa, Staphylococcus aureus, periprosthetic joint infection
Article Details
How to Cite
BEVERS, Raymond T.J. et al.
The Role of Material Technologies Targeting P. Aeruginosa and S. Aureus Quorum Sensing in Biofilm Formation.
Medical Research Archives, [S.l.], v. 10, n. 10, oct. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3007>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v10i10.3007.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Tande AJ, Patel R. Prosthetic joint infection. Clin Microbiol Rev. Apr 2014;27(2):302-45. doi:10.1128/cmr.00111-13
4. Goud AL, Harlianto NI, Ezzafzafi S, Veltman ES, Bekkers JEJ, van der Wal BCH. Reinfection rates after one- and two-stage revision surgery for hip and knee arthroplasty: a systematic review and meta-analysis. Archives of Orthopaedic and Trauma Surgery. 2021/09/30 2021;doi:10.1007/s00402-021-04190-7
5. Zardi EM, Franceschi F. Prosthetic joint infection. A relevant public health issue. J Infect Public Health. Dec 2020;13(12):1888-1891. doi:10.1016/j.jiph.2020.09.006
6. Signore A, Sconfienza LM, Borens O, et al. Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging. Apr 2019;46(4):971-988. doi:10.1007/s00259-019-4263-9
7. Shah NB, Osmon DR, Steckelberg JM, et al. Pseudomonas Prosthetic Joint Infections: A Review of 102 Episodes. J Bone Jt Infect. 2016;1:25-30. doi:10.7150/jbji.15722
8. Craft KM, Nguyen JM, Berg LJ, Townsend SD. Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype. 10.1039/C9MD00044E. MedChemComm. 2019;10(8):1231-1241. doi:10.1039/C9MD00044E
9. Totté JE, van der Feltz WT, Bode LG, van Belkum A, van Zuuren EJ, Pasmans SG. A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea. Eur J Clin Microbiol Infect Dis. Jul 2016;35(7):1069-77. doi:10.1007/s10096-016-2647-3
10. Pendleton JN, Gorman SP, Gilmore BF. Clinical relevance of the ESKAPE pathogens. Expert Rev Anti Infect Ther. Mar 2013;11(3):297-308. doi:10.1586/eri.13.12
11. Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. Mar 2018;18(3):318-327. doi:10.1016/s1473-3099(17)30753-3
12. Zimmerli W, Sendi P. Orthopaedic biofilm infections. Apmis. Apr 2017;125(4):353-364. doi:10.1111/apm.12687
13. Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. Current and future approaches to the prevention and treatment of staphylococcal medical device-related infections. Current Pharmaceutical Design. 01 Dec 2015;21(1):100-113.
14. Shah S, Gaikwad S, Nagar S, et al. Biofilm inhibition and anti-quorum sensing activity of phytosynthesized silver nanoparticles against the nosocomial pathogen Pseudomonas aeruginosa. Biofouling. Jan 2019;35(1):34-49. doi:10.1080/08927014.2018.1563686
15. Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol. Jul 2002;292(2):107-13. doi:10.1078/1438-4221-00196
16. Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother. Jul 2001;48 Suppl 1:5-16. doi:10.1093/jac/48.suppl_1.5
17. Dincer S, Uslu F, Delik A. Antibiotic Resistance in Biofilm. 2020.
18. Kaldalu N, Hauryliuk V, Tenson T. Persisters—as elusive as ever. Applied Microbiology and Biotechnology. 2016/08/01 2016;100(15):6545-6553. doi:10.1007/s00253-016-7648-8
19. Barrett TC, Mok WWK, Murawski AM, Brynildsen MP. Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic. Nature Communications. 2019/03/12 2019;10(1):1177. doi:10.1038/s41467-019-09058-4
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