Hybrid tumours of the parotid gland – 7 years’ experience
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Abstract
Abstract
Aims: Hybrid tumours (HTs) of the parotid gland (PG) are extremely uncommon. A review of the literature revealed that most reported cases were either a combination of two distinct benign neoplasms or a benign neoplasm and another malignant tumour. The limited number of reported HTs cases makes the prognostic evaluation and treatment selection difficult. Here, we report the literature review and our experience with HTs in the PG.
Methods and Material: The present study evaluated retrospectively 450 cases of the PG tumours, which were treated in our hospital. Out of 450 parotidectomies performed in 5 cases (1.1%) HTs were diagnosed on postoperative histopathology examination. Moreover the article includes a short review of the literature on hybrid neoplasms of the PG.
Results: Based on the literature review HTs have been described in less than 0.1% of all the PG tumours. Only 21 cases of hybrid malignant neoplasms (with our 2 cases) have been reported thus far in the literature. Three of 5 our HTs cases were diagnosed as benign HTs and 2 cases as malignant HTs. The most common component of tumours was a pleomorphic adenoma. In two cases it was combined with Warthin tumour and in one case with basal cell adenoma. Malignant HTs were composed of squamous cells carcinoma (SCC) and Burkitt lymphoma in the first case and polymorphous carcinoma and low grade lymphoma malignum lymphociticum in the second case. Thus we paid a special attention to these cases in the article and we present detailed medical history of these two cases.
Conclusions: The histogenesis of HTs is largely unknown. Recognition of HT is important particularly when the component tumours have different biological behaviour. However, the limited number of reported cases makes the prognostic evaluation and treatment selection difficult.
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References
[2] Ballestin C., Lopez-Carreira M., and Lopez J.I. 1996. "Combined acinic cell mucoepidermoid carcinoma of the parotid gland. Report of a case with immunohistochemical study". APMIS 104(2): 99-102.
[3] Barnes L., Myers E.N., and Prokopakis E.P. 1998. "Primary malignant lymphoma of the parotid gland". Arch Otolaryngol Head Neck Surg 124(5): 573-577.
[4] Carlsoo B., and Ekstrand T. 1977. "Unilateral multiple mixed tumours of the parotid gland". J Laryngol Otol 91(7): 629-632.
[5] Chetty R., Medley P., and Essa A. 2000. "Hybrid carcinomas of salivary glands". Arch Pathol Lab Med 124(4): 494-496. doi: 10.1043/1543-2165(2000)124<494a:IR>2.0.CO;2
[6] Cheuk W., and Chan J.K. 2007. "Advances in salivary gland pathology". Histopathology 51(1): 1-20. doi: 10.1111/j.1365-2559.2007.02719.x
[7] Croitoru C.M., Suarez P.A., and Luna M.A. 1999. "Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature". Arch Pathol Lab Med 123(8): 698-702. doi: 10.1043/0003-9985(1999)123<0698:HCOSG>2.0.CO;2
[8] Curry J.L., Petruzzelli G.J., McClatchey K.D., and Lingen M.W. 2002. "Synchronous benign and malignant salivary gland tumors in ipsilateral glands: a report of two cases and a review of literature". Head Neck 24(3): 301-306.
[9] De Cesare A., Bononi M., Atella F., Angelini M., and Lauretti C. 1997. "Primary non-Hodgkin lymphoma of the parotid gland". Panminerva Med 39(3): 228-232.
[10] Edge S.B., and Compton C.C. 2010. "The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM". Ann Surg Oncol 17(6): 1471-1474. doi: 10.1245/s10434-010-0985-4
[11] Gleeson M.J., Bennett M H., and Cawson R.A. 1986. "Lymphomas of salivary glands". Cancer 58(3): 699-704.
[12] Kainuma K., Oshima A., Suzuki H., Fukushima M., Shimojo H., and Usami S. 2010. "Hybrid carcinoma of the parotid gland: report of a case (epithelial-myoepithelial carcinoma and salivary duct carcinoma) and review of the literature". Acta Otolaryngol 130(1): 185-189. doi: 10.3109/00016480902930458
[13] Murphy J.G., Lonsdale R., Premachandra D., and Hellquist H.B. 2006. "Salivary hybrid tumour: adenoid cystic carcinoma and basal cell adenocarcinoma". Virchows Arch 448(2): 236-238. doi: 10.1007/s00428-005-0135-8
[14] Nagao T., Sugano I., Ishida Y., Asoh A., Munakata S., Yamazaki K., Ebihara Y. 2002. "Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic, immunohistochemical, and p53 gene alteration analysis". Mod Pathol 15(7): 724-733. doi: 10.1097/01.MP.0000018977.18942.FD
[15] Nichols R.D., Rebuck J.W., and Sullivan J.C. 1982. "Lymphoma and the parotid gland". Laryngoscope 92(4): 365-369.
[16] Piana S., Damiani S., Asioli S., Magrini E., Barbieri W., and Cavazza A. 2004. "Epstein-Barr-positive lymphoepithelial carcinoma and epi-myoepithelial cell carcinoma of the parotid gland: a hitherto unreported example of hybrid tumour". Virchows Arch 445(4): 425-428. doi: 10.1007/s00428-004-1075-4
[17] Sabri A., Bawab I., Khalifeh I., and Alam E. 2015. "Hybrid tumor of the parotid gland: a case report and review of the literature". 2015. Case Rep Otolaryngol, 192453. doi: 10.1155/2015/192453
[18] Schmid U., Helbron D., and Lennert K. 1982. "Primary malignant lymphomas localized in salivary glands". Histopathology 6(6): 673-687.
[19] Seifert G., and Donath K. 1996. "Hybrid tumours of salivary glands. Definition and classification of five rare cases". Eur J Cancer B Oral Oncol 32B(4): 251-259.
[20] Shikhani A., Samara M., Allam C., Salem P., and Lenhard R. 1987. "Primary lymphoma in the salivary glands: report of five cases and review of the literature". Laryngoscope 97(12):1438-1442. doi: 10.1288/00005537-198712000-00011
[21] Zardawi I.M. 2000. "Hybrid carcinoma of the salivary gland". Histopathology 37(3): 283-284.
[22] Zeebregts C.J., Mastboom W.J., van Noort G., and van Det R.J. 2003. "Synchronous tumours of the unilateral parotid gland: rare or undetected?" J Craniomaxillofac Surg 31(1): 62-66.