Surgical Interventions as a Treatment Option for Severe Dysphagia with Intractable Aspiration: Concept, Indications, and Efficacy

Main Article Content

Masamitsu Hyodo Asuka Nagao Kaori Tanaka

Abstract

The incidence of dysphagia is increasing, particularly among the elderly according to varied of causes. Patients with severe dysphagia are unable to take food orally and are at risk for life-threatening aspiration pneumonia. Treatments for swallowing disorders focus on restoring oral food intake and preventing recurrent aspiration pneumonia. Therefore, swallowing rehabilitation and food texture modifications are essential. However, in cases with severe or progressive dysphagia, these conservative treatments may not restore oral feeding and prevent intractable aspiration pneumonia. In these cases, surgical interventions has recently been attracted as an alternative treatment option. In this article, we present its concept, indications, and efficacy.


Surgeries to restore swallowing function address impaired pharyngolaryngeal motor function during the pharyngeal swallowing stage while preserving laryngeal functions. These procedures include laryngeal elevation, cricopharyngeal myotomy, and vocal cord medialization. Meanwhile, aspiration prevention surgeries reduce the risk of aspiration pneumonia by separating the lower respiratory tract from the pharynx and larynx. These procedures include total laryngectomy, laryngotracheal separation, and glottal closure; although they do not spare laryngeal functions, they prevent aspiration pneumonia completely, improve quality of life, and reduce the burden on caregivers. Clinicians should be aware of surgical interventions as a possible treatment option for intractable dysphagia. Establishment and popularization of the surgical indications are the future issues.

Article Details

How to Cite
HYODO, Masamitsu; NAGAO, Asuka; TANAKA, Kaori. Surgical Interventions as a Treatment Option for Severe Dysphagia with Intractable Aspiration: Concept, Indications, and Efficacy. Medical Research Archives, [S.l.], v. 10, n. 9, sep. 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3113>. Date accessed: 02 may 2024. doi: https://doi.org/10.18103/mra.v10i9.3113.
Section
Research Articles

References

1) Gleeson DC. Oropharyngeal swallowing and aging: a review. J Commun Disord. 1999;32(6):373–396.
2) Wirth R, Dziewas R, Beck AM, et al. Oropharyngeal dysphagia in older persons - from pathophysiology to adequate intervention: a review and summary of an international expert meeting. Clin Interv Aging. 2016;11:189–208.
3) Baijens LW, Clavé P, Cras P, et al. European Society for Swallowing Disorders - European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome. Clin Interv Aging. 2016;11:1403–1428.
4) Ebihara S, Sekiya H, Miyagi M, Ebihara T, Okazaki T. Dysphagia, dystussia, and aspiration pneumonia in elderly people. J Thorac Dis. 2016;8(3):632–639.
5) Yamaya M, Yanai M, Ohrui T, Arai H, Sasaki H. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc. 2001;49(1):85–90.
6) Shin T, Tsuda K, Takagi S. Surgical treatment for dysphagia of neuromuscular origin. Folia Phoniatr Logop. 1999;51(4-5):213–219.
7) Kelly JH: Management of upper esophageal sphincter disorders: indications and complications of myotomy. Am J Med. 2000;108(Suppl 4a):43S–46S.
8) Matsuo K, Palmer JB. Anatomy and physiology of feeding and swallowing: normal and abnormal. Phys Med Rehabil Clin N Am. 2008;19(4):691–707.
9) Bass NH. The neurology of swallowing. In: Groher ME. ed. Dysphagia: Diagnosis and Management. 3rd ed. Newton: Butterworth-Heinemann 1997;pp7–35.
10) Montgomery WW. Surgery to prevent aspiration. Arch Otolaryngol. 1975;101(11):679–82.
11) Sasaki CT, Milmoe G, Yanagisawa E, Berry K, Kirchner JA. Surgical closure of the larynx for intractable aspiration. Arch Otolaryngol. 1980;106(7):422–423.
12) Kimura Y, Kishimoto S, Sumi T, Uchiyama M, Ohno K, Kobayashi H, et al. Improving the quality of life of patients with severe dysphagia by surgically closing the larynx. Ann Otol Rhinol Laryngol. 2019;128(2):96–103.
13) Nagao A, Tanaka K, Hirose K, Komori M, Hyodo M. Evaluation of surgical intervention to improve swallowing function. J Jpn Bronchoesophagol Soc. 2016; 67(6):398–405.
14) Goode RL. Laryngeal suspension in head and neck surgery. Laryngoscope. 1976; 86(3):349–355.
15) Fujimoto Y, Hasegawa Y, Yamada H, Ando A, Nakashima T. Swallowing function following extensive resection of oral or oropharyngeal cancer with laryngeal suspension and cricopharyngeal myotomy. Laryngoscope. 2007;117(8):1343–1348.
16) Fujiwara K, Koyama S, Fukuhara T, Takeuchi H: Successful surgical treatment for dysphagia secondary to descending necrotizing mediastinitis. Yonago Acta Med. 2019;62(3):253–257.
17) Kahrilas PJ, Dodds WJ, Dent J, Logemann J, Shaker R. Upper esophageal sphincter function during deglutition. Gastroenterol. 1988; 95(1):52–62.
18) Cook IJ, Dodds WJ, Dantas RO, et al. Opening mechanisms of the human upper esophageal sphincter. Am J Physiol. 1989;257 (5 Pt 1):G748–759.
19) Kaplan S. Paralysis of deglutition, a post-poliomyelitis complication treated by section of the cricopharyngeus muscle. Ann Surg. 1951;133(4):572–573.
20) Lindgren S, Ekberg O. Cricopharyngeal myotomy in the treatment of dysphagia. Clin Otolaryngol Allied Sci. 1990;15(3):221–227.
21) Kelly JH. Management of upper esophageal sphincter disorders: indications and complications of myotomy. Am J Med. 2000;108(Suppl 4a):43S–46S.
22) Hyodo M, Aibara R, Kawakita S, Yumoto E. Histochemical study of the canine inferior pharyngeal constrictor muscle: implications for its function. Acta Otolaryngol. 1998;118(2):272–279.
23) Ho AS, Morzaria S, Damrose EJ. Carbon dioxide laser-assisted endoscopic cricopharyngeal myotomy with primary mucosal closure. Ann Otol Rhinol Laryngol. 2011;120:33–39.
24) Chitose S, Sato K, Hamakawa S, Umeno H, Nakashima T. A new paradigm of endoscopic cricopharyngeal myotomy with CO2 Laser. Laryngoscope. 2011; 121:567–570.
25) Huntley C, Boon M, Spiegel J. Open vs. endoscopic cricopharyngeal myotomy; Is there a difference? Am J Otolaryngol. 2017;38(4):405–407.
26) Isshiki N, Okamura H, Ishikawa T. Thyroplasty type I (lateral compression) for dysphonia due to vocal cord paralysis or atrophy. Acta Otolaryngol. 1975;80(5-6):465–473.
27) Flint PW, Purcell LL, Cummings CW. Pathophysiology and indications for medialization thyroplasty in patients with dysphagia and aspiration. Otolaryngol Head Neck Surg. 1997;116(3):349–354.
28) Isshiki N, Tanabe M, Sawada M. Arytenoid adduction for unilateral vocal cord paralysis. Arch Otolaryngol. 1978;104(10):555–558.
29) Patel NJ, Kerschner JE, Merati AL. The use of injectable collagen in the management of pediatric vocal unilateral cord paralysis. Int J Pediatr Otorhinolaryngol. 2003;67(12): 1355–1360.
30) Lindeman RC. Diverting the paralyzed larynx: a reversible procedure for intractable aspiration. Laryngoscope. 1975;85(1):157–180.
31) Baron BC, Dedo HH: Separation of the larynx and trachea for intractable aspiration. Laryngoscope. 1980;90(12):1927–1932.
32) Eibling DE, Snyderman CH, Eibling C: Laryngotracheal separation for intractable aspiration: a retrospective review of 34 patients. Laryngoscope. 1995;105(1):83–85.
33) Cannon CR, McLean WC. Laryngectomy for chronic aspiration. Am J Otolaryngol. 1982; 3(2):145–149.
34) Eisele DW, Yarington CT Jr, Lindeman RC, Larrabee WF Jr: The tracheoesophageal diversion and laryngotracheal separation procedures for treatment of intractable aspiration. Am J Surg. 1989;157(2):230–236.
35) Shima H, Kitagawa H, Wakisaka M, Furuta S, Hamano S, Aoba T. The usefulness of laryngotracheal separation in the treatment of severe motor and intellectual disabilities. Pediatr Surg Int. 2010;26(10):1041–1044.
36) Takano K, Kurose M, Mitsuzawa H, Nagaya T, Himi T: Clinical outcomes of tracheoesophageal diversion and laryngotracheal separation for aspiration in patients with severe motor and intellectual disability. Acta Otolaryngol. 2015;135(12):1304–1310.
37) Takano S, Goto T, Kabeya M, Tayama N. Surgical closure of the larynx for the treatment of intractable aspiration: surgical technique and clinical results. Laryngoscope. 2012; 122(6):1273–1278.
38) Yokoi S, Nishio N, Maruo T, et al.: Safety and clinical benefits of laryngeal closure in patients with amyotrophic lateral Sclerosis. Dysphagia. 2022. doi:10.1007/s00455-022-10454-0. Online ahead of print.