Respiratory and Neuromuscular Impairment Resulting from Onco-Hematological Diseases and Treatment in Children and Adolescents: A Physiotherapeutic Approach Review
Main Article Content
Abstract
Onco-hematological diseases are serious conditions and often require aggressive treatment that can lead to systemic complications, consequently affecting musculoskeletal functions as well as physical and functional capacity. Respiratory complications can lead to a greater frequency of hospitalizations and immobility, creating a cycle of sedentarism as well as an increase in morbidity and mortality. The goal of physical therapy in such cases is to restore compromised functions in affected children and adolescents and ensure the performance of activities of daily living and better development.The aim of this review was to bring to light the dysfunctions promoted by onco-hematological diseases of childhood in order to understand the best way to approach the treatment for this population.In this review, the functional alterations of sickle cell anemia, leukemia and bone marrow transplantation were addressed, as well as the interventions used by physiotherapy for the treatment.
Article Details
How to Cite
GOMES, Evelim Leal de Freitas Dantas et al.
Respiratory and Neuromuscular Impairment Resulting from Onco-Hematological Diseases and Treatment in Children and Adolescents: A Physiotherapeutic Approach.
Medical Research Archives, [S.l.], v. 10, n. 10, oct. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3184>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.18103/mra.v10i10.3184.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Pulmonary Manifestations of Hematologic and Oncologic Diseases in Children. Pediatr Clin North Am. 2021;68(1):61-80.
2. Savio C, Garaventa A, Gremmo M, et al. Feasibility of integrated home/hospital physiotherapeutic support for children with cancer. Support Care Cancer. 2007;15(1):101-104.
3. Manchola-González JD, Bagur-Calafat C, Girabent-Farrés M, et al. Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial. Support Care Cancer. 2020;28(7):3171-3178.
4. Fenn WO. Mechanics of respiration. Am J Med. 1951;10(1):77-90.
5. Troyer AD, De Troyer A. Mechanics of the Chest Wall during Restrictive Thoracic Strapping. Respiration. 1980;39(5):241-250. doi:10.1159/000194223
6. Hlastala MP, Berger AJ. Physiology of Respiration. Oxford University Press, USA; 2001.
7. Therapeutic strategies in Sickle Cell Anemia: The past present and future. Life Sci. 2017;178:100-108.
8. Greenough A, Hunt K, Charles E. Pulmonary complications of haematologic disorders. In: Pulmonary Complications of Non-Pulmonary Pediatric Disorders. Springer International Publishing; 2018:31-49.
9. Sales A. Anemia falciforme. Prefeitura da Cidade, SUS - Secretaria de Saúde; 2005.
10. Takahashi T, Okubo Y, Pereda MA, Handa A, Miller S. Factors Associated With Mechanical Ventilation Use in Children With Sickle Cell Disease and Acute Chest Syndrome. Pediatr Crit Care Med. 2018;19(9):801-809.
11. Heilbronner C, Merckx A, Brousse V, et al. Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. Pediatr Crit Care Med. 2018;19(5):e235-e241.
12. Ahmad FA, Macias CG, Allen JY. The use of incentive spirometry in pediatric patients with sickle cell disease to reduce the incidence of acute chest syndrome. J Pediatr Hematol Oncol. 2011;33(6):415-420.
13. Adeniyi AF, Saminu KS. Non Communicable Diseases: Local incentive spirometry improves peak expiratory flow rate in teenage sickle cell anaemia patients: a randomized pilot trial. Published online March 25, 2012. Accessed September 12, 2022. https://tspace.library.utoronto.ca/handle/1807/50977
14. Willen SM, Cohen R, Rodeghier M, et al. Age is a predictor of a small decrease in lung function in children with sickle cell anemia. Am J Hematol. 2018;93(3):408-415.
15. Chaudry RA, Bush A, Rosenthal M, Crowley S. The impact of sickle cell disease on exercise capacity in children. Chest. 2013;143(2):478-484.
16. Liem RI, Lanzkron S, D Coates T, et al. American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease. Blood Adv. 2019;3(23):3867-3897.
17. Onyekwere OC, Campbell A, Teshome M, et al. Pulmonary hypertension in children and adolescents with sickle cell disease. Pediatr Cardiol. 2008;29(2):309-312.
18. Darbari DS, Onyekwere O, Nouraie M, et al. Markers of Severe Vaso-Occlusive Painful Episode Frequency in Children and Adolescents with Sickle Cell Anemia. J Pediatr. 2012;160(2):286-290.
19. Machado R, Machado A, Almeida HS, Carvalho A, Sá KN. Dor em crianças e adolescentes com doença falciforme: estudo observacional. Revista Pesquisa em Fisioterapia. 2021;11(2):384-392. doi:10.17267/2238-2704rpf.v11i2.3771
20. Yanaguizawa M, Taberner GS, Cardoso FN de C, Natour J, Fernandes A da RC. Diagnóstico por imagem na avaliação da anemia falciforme. Rev Bras Reumatol. 2008;48(2):102-105.
21. Demaret P, Pettersen G, Hubert P, Teira P, Emeriaud G. The critically-ill pediatric hemato-oncology patient: epidemiology, management, and strategy of transfer to the pediatric intensive care unit. Ann Intensive Care. 2012;2(1):14.
22. Marchese V, Rock K, York T, Ruble K, Gray VL. The Efficacy of Targeted Exercise on Gross Motor and Neuromuscular Performance in Survivors of Childhood Leukemia: A Pilot Study. Front Pediatr. 2022;10:891650.
23. Wilson CL, Gawade PL, Ness KK. Impairments that influence physical function among survivors of childhood cancer. Children. 2015;2(1):1-36.
24. Grimshaw SL, Taylor NF, Mechinaud F, Shields N. Assessment of physical function in children with cancer: A systematic review. Pediatric Blood & Cancer. 2018;65(12):e27369. doi:10.1002/pbc.27369
25. Mertens AC, Yasui Y, Liu Y, et al. Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer. 2002;95(11):2431-2441.
26. Spahr J, Weiner DJ, Stokes DC, Kurland G. 64 - Pulmonary Disease in the Pediatric Patient With Acquired Immunodeficiency States. In: Wilmott RW, Deterding R, Li A, et al., eds. Kendig’s Disorders of the Respiratory Tract in Children (Ninth Edition). Elsevier; 2019:923-943.e7.
27. O’Connor D, Loke J, Brown M, Stanworth SJ, Young A, Prue G. Non-pharmacological supportive-care interventions in acute myeloid leukaemia: a review of randomised controlled trials. Br J Haematol. 2021;195(1):e97-e113.
28. Roussenq KR, Lautenschlager AP, Dubón AP, Roussenq SC, Dias M, Benetti M. The performance of physiotherapeutic conducts in oncology patients interned in a pediatric intensive care unit: A systematic review. Int J Health Sci . 2022;16(3):44-53.
29. Hinds PS, Linder L. Pediatric Oncology Nursing: Defining Care Through Science. Springer Nature; 2020.
30. Dias MM, Loureiro W, Soeiro LB. PRESCRIÇÃO DE ATIVIDADES FÍSICAS PARA PACIENTES EM TRATAMENTO ONCOLÓGICO. Bacharelado em Educação Física: temas emergentes na iniciação à pesquisa. Published online 2022:328-343. doi:10.48209/978-65-89949-ef-i
31. Mohammed J, Smith SR, Burns L, et al. Role of Physical Therapy before and after Hematopoietic Stem Cell Transplantation: White Paper Report. Biol Blood Marrow Transplant. 2019;25(6):e191-e198.
32. Pancera CF, Hayashi M, Fregnani JH, Negri EM, Deheinzelin D, de Camargo B. Noninvasive ventilation in immunocompromised pediatric patients: eight years of experience in a pediatric oncology intensive care unit. J Pediatr Hematol Oncol. 2008;30(7):533-538.
33. Broglie L, Fretham C, Al-Seraihy A, et al. Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019;25(10):2024-2030.
34. Griese M, Rampf U, Hofmann D, Fuhrer M, Reinhardt D, Bender-Götze C. Pulmonary complications after bone marrow transplantation in children: Twenty-four years of experience in a single pediatric center. Pediatric Pulmonology. 2000;30(5):393-401. doi:10.1002/1099-0496(200011)30:5<393::aid-ppul5>3.0.co;2-w
35. Lago ASD do, Zaffarani C, Mendonça JFB, Moran CA, Costa D, Gomes EL de FD. Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis. Hematol Transfus Cell Ther. 2021;43(3):313-323.
36. Omwanghe OA, Muntz DS, Kwon S, et al. Self-Reported Physical Activity and Exercise Patterns in Children With Sickle Cell Disease. Pediatr Exerc Sci. 2017;29(3):388-395.
37. Hsu LL, Batts BK, Rau JL. Positive expiratory pressure device acceptance by hospitalized children with sickle cell disease is comparable to incentive spirometry. Respir Care. 2005;50(5):624-627.
38. Galvão F, Zanoni CT, Moreira MM, Paschoal IA, Saad STO. Effects of home-based inspiratory muscle training on sickle cell disease (SCD) patients. Hematol Transfus Cell Ther. 2021;43(4):443-452.
39. Bernard AW, Yasin Z, Venkat A. Acute chest syndrome of sickle cell disease. Hosp Physician. 2007;44(5):23.
40. Vizinová H, Malincíková J, Klásková E, Wiedermann J. Exercise cardiorespiratory parameters in children motivated to physical activity after treatment for acute lymphoblastic leukemia. Cas Lek Cesk. 2002;141(15):491-493.
41. Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJL. Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev. 2016;3:CD008796.
2. Savio C, Garaventa A, Gremmo M, et al. Feasibility of integrated home/hospital physiotherapeutic support for children with cancer. Support Care Cancer. 2007;15(1):101-104.
3. Manchola-González JD, Bagur-Calafat C, Girabent-Farrés M, et al. Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial. Support Care Cancer. 2020;28(7):3171-3178.
4. Fenn WO. Mechanics of respiration. Am J Med. 1951;10(1):77-90.
5. Troyer AD, De Troyer A. Mechanics of the Chest Wall during Restrictive Thoracic Strapping. Respiration. 1980;39(5):241-250. doi:10.1159/000194223
6. Hlastala MP, Berger AJ. Physiology of Respiration. Oxford University Press, USA; 2001.
7. Therapeutic strategies in Sickle Cell Anemia: The past present and future. Life Sci. 2017;178:100-108.
8. Greenough A, Hunt K, Charles E. Pulmonary complications of haematologic disorders. In: Pulmonary Complications of Non-Pulmonary Pediatric Disorders. Springer International Publishing; 2018:31-49.
9. Sales A. Anemia falciforme. Prefeitura da Cidade, SUS - Secretaria de Saúde; 2005.
10. Takahashi T, Okubo Y, Pereda MA, Handa A, Miller S. Factors Associated With Mechanical Ventilation Use in Children With Sickle Cell Disease and Acute Chest Syndrome. Pediatr Crit Care Med. 2018;19(9):801-809.
11. Heilbronner C, Merckx A, Brousse V, et al. Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. Pediatr Crit Care Med. 2018;19(5):e235-e241.
12. Ahmad FA, Macias CG, Allen JY. The use of incentive spirometry in pediatric patients with sickle cell disease to reduce the incidence of acute chest syndrome. J Pediatr Hematol Oncol. 2011;33(6):415-420.
13. Adeniyi AF, Saminu KS. Non Communicable Diseases: Local incentive spirometry improves peak expiratory flow rate in teenage sickle cell anaemia patients: a randomized pilot trial. Published online March 25, 2012. Accessed September 12, 2022. https://tspace.library.utoronto.ca/handle/1807/50977
14. Willen SM, Cohen R, Rodeghier M, et al. Age is a predictor of a small decrease in lung function in children with sickle cell anemia. Am J Hematol. 2018;93(3):408-415.
15. Chaudry RA, Bush A, Rosenthal M, Crowley S. The impact of sickle cell disease on exercise capacity in children. Chest. 2013;143(2):478-484.
16. Liem RI, Lanzkron S, D Coates T, et al. American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease. Blood Adv. 2019;3(23):3867-3897.
17. Onyekwere OC, Campbell A, Teshome M, et al. Pulmonary hypertension in children and adolescents with sickle cell disease. Pediatr Cardiol. 2008;29(2):309-312.
18. Darbari DS, Onyekwere O, Nouraie M, et al. Markers of Severe Vaso-Occlusive Painful Episode Frequency in Children and Adolescents with Sickle Cell Anemia. J Pediatr. 2012;160(2):286-290.
19. Machado R, Machado A, Almeida HS, Carvalho A, Sá KN. Dor em crianças e adolescentes com doença falciforme: estudo observacional. Revista Pesquisa em Fisioterapia. 2021;11(2):384-392. doi:10.17267/2238-2704rpf.v11i2.3771
20. Yanaguizawa M, Taberner GS, Cardoso FN de C, Natour J, Fernandes A da RC. Diagnóstico por imagem na avaliação da anemia falciforme. Rev Bras Reumatol. 2008;48(2):102-105.
21. Demaret P, Pettersen G, Hubert P, Teira P, Emeriaud G. The critically-ill pediatric hemato-oncology patient: epidemiology, management, and strategy of transfer to the pediatric intensive care unit. Ann Intensive Care. 2012;2(1):14.
22. Marchese V, Rock K, York T, Ruble K, Gray VL. The Efficacy of Targeted Exercise on Gross Motor and Neuromuscular Performance in Survivors of Childhood Leukemia: A Pilot Study. Front Pediatr. 2022;10:891650.
23. Wilson CL, Gawade PL, Ness KK. Impairments that influence physical function among survivors of childhood cancer. Children. 2015;2(1):1-36.
24. Grimshaw SL, Taylor NF, Mechinaud F, Shields N. Assessment of physical function in children with cancer: A systematic review. Pediatric Blood & Cancer. 2018;65(12):e27369. doi:10.1002/pbc.27369
25. Mertens AC, Yasui Y, Liu Y, et al. Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer. 2002;95(11):2431-2441.
26. Spahr J, Weiner DJ, Stokes DC, Kurland G. 64 - Pulmonary Disease in the Pediatric Patient With Acquired Immunodeficiency States. In: Wilmott RW, Deterding R, Li A, et al., eds. Kendig’s Disorders of the Respiratory Tract in Children (Ninth Edition). Elsevier; 2019:923-943.e7.
27. O’Connor D, Loke J, Brown M, Stanworth SJ, Young A, Prue G. Non-pharmacological supportive-care interventions in acute myeloid leukaemia: a review of randomised controlled trials. Br J Haematol. 2021;195(1):e97-e113.
28. Roussenq KR, Lautenschlager AP, Dubón AP, Roussenq SC, Dias M, Benetti M. The performance of physiotherapeutic conducts in oncology patients interned in a pediatric intensive care unit: A systematic review. Int J Health Sci . 2022;16(3):44-53.
29. Hinds PS, Linder L. Pediatric Oncology Nursing: Defining Care Through Science. Springer Nature; 2020.
30. Dias MM, Loureiro W, Soeiro LB. PRESCRIÇÃO DE ATIVIDADES FÍSICAS PARA PACIENTES EM TRATAMENTO ONCOLÓGICO. Bacharelado em Educação Física: temas emergentes na iniciação à pesquisa. Published online 2022:328-343. doi:10.48209/978-65-89949-ef-i
31. Mohammed J, Smith SR, Burns L, et al. Role of Physical Therapy before and after Hematopoietic Stem Cell Transplantation: White Paper Report. Biol Blood Marrow Transplant. 2019;25(6):e191-e198.
32. Pancera CF, Hayashi M, Fregnani JH, Negri EM, Deheinzelin D, de Camargo B. Noninvasive ventilation in immunocompromised pediatric patients: eight years of experience in a pediatric oncology intensive care unit. J Pediatr Hematol Oncol. 2008;30(7):533-538.
33. Broglie L, Fretham C, Al-Seraihy A, et al. Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019;25(10):2024-2030.
34. Griese M, Rampf U, Hofmann D, Fuhrer M, Reinhardt D, Bender-Götze C. Pulmonary complications after bone marrow transplantation in children: Twenty-four years of experience in a single pediatric center. Pediatric Pulmonology. 2000;30(5):393-401. doi:10.1002/1099-0496(200011)30:5<393::aid-ppul5>3.0.co;2-w
35. Lago ASD do, Zaffarani C, Mendonça JFB, Moran CA, Costa D, Gomes EL de FD. Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis. Hematol Transfus Cell Ther. 2021;43(3):313-323.
36. Omwanghe OA, Muntz DS, Kwon S, et al. Self-Reported Physical Activity and Exercise Patterns in Children With Sickle Cell Disease. Pediatr Exerc Sci. 2017;29(3):388-395.
37. Hsu LL, Batts BK, Rau JL. Positive expiratory pressure device acceptance by hospitalized children with sickle cell disease is comparable to incentive spirometry. Respir Care. 2005;50(5):624-627.
38. Galvão F, Zanoni CT, Moreira MM, Paschoal IA, Saad STO. Effects of home-based inspiratory muscle training on sickle cell disease (SCD) patients. Hematol Transfus Cell Ther. 2021;43(4):443-452.
39. Bernard AW, Yasin Z, Venkat A. Acute chest syndrome of sickle cell disease. Hosp Physician. 2007;44(5):23.
40. Vizinová H, Malincíková J, Klásková E, Wiedermann J. Exercise cardiorespiratory parameters in children motivated to physical activity after treatment for acute lymphoblastic leukemia. Cas Lek Cesk. 2002;141(15):491-493.
41. Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJL. Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev. 2016;3:CD008796.