The Role of Coronary Microvascular Disease in Cardiomyophaties
Main Article Content
Abstract
Coronary microvascular disease (CMD) makes reference to the anatomically and functionally disorders affecting vascular compartments (<400 mm diameter), covering a broad range of clinical conditions in which the structure and function of the coronary microcirculation is affected. CMD is characterized by an impaired coronary flow reserve (cut-off values of 2.0-2.5) or an abnormally index of coronary microvascular resistance (IMR >25) and/or focal or diffuse vasoconstriction during acetylcholine challenge, with an important role in myocardial perfusion. The aim of this work is to review CMD, definition, clinical manifestations, diagnosis method (non invasive and invasive approach) and the role of CMD in the main cardiomiophaties, such as Hypertrophic cardiomiopathy, none idiomatic dilated cardiomiopathy and infiltrative miocardiophaty.
Article Details
How to Cite
BAYÓN, Jeremías et al.
The Role of Coronary Microvascular Disease in Cardiomyophaties.
Medical Research Archives, [S.l.], v. 10, n. 10, oct. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3210>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v10i10.3210.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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11. Shah NR, Charytan DM, Murthy VL, et al. Prognostic Value of Coronary Flow Reserve in Patients with Dialysis-Dependent ESRD. J Am Soc Nephrol JASN. 2016;27(6):1823-1829. doi:10.1681/ASN.2015030301
12. Wasserman DH, Wang TJ, Brown NJ. The Vasculature in Prediabetes. Circ Res. 2018;122(8):1135-1150. doi:10.1161/CIRCRESAHA.118.311912
13. Reindl M, Reinstadler SJ, Feistritzer HJ, et al. Relation of Low-Density Lipoprotein Cholesterol With Microvascular Injury and Clinical Outcome in Revascularized ST-Elevation Myocardial Infarction. J Am Heart Assoc. 2017;6(10):e006957. doi:10.1161/JAHA.117.006957
14. Koller A. Perspectives: Microvascular endothelial dysfunction and gender. Eur Heart J Suppl J Eur Soc Cardiol. 2014;16(Suppl A):A16-A19. doi:10.1093/eurheartj/sut005
15. Zhang Z, Takarada S, Molloi S. Assessment of coronary microcirculation in a swine animal model. Am J Physiol Heart Circ Physiol. 2011;301(2):H402-408. doi:10.1152/ajpheart.00213.2011
16. Radico F, Cicchitti V, Zimarino M, De Caterina R. Angina pectoris and myocardial ischemia in the absence of obstructive coronary artery disease: practical considerations for diagnostic tests. JACC Cardiovasc Interv. 2014;7(5):453-463. doi:10.1016/j.jcin.2014.01.157
17. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation. 1995;92(3):320-326. doi:10.1161/01.cir.92.3.320
18. Ong P, Athanasiadis A, Borgulya G, Mahrholdt H, Kaski JC, Sechtem U. High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries). J Am Coll Cardiol. 2012;59(7):655-662. doi:10.1016/j.jacc.2011.11.015
19. Hamasaki S, Al Suwaidi J, Higano ST, Miyauchi K, Holmes DR, Lerman A. Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy. J Am Coll Cardiol. 2000;35(6):1654-1660. doi:10.1016/s0735-1097(00)00594-5
20. Choi BJ, Matsuo Y, Aoki T, et al. Coronary endothelial dysfunction is associated with inflammation and vasa vasorum proliferation in patients with early atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(11):2473-2477. doi:10.1161/ATVBAHA.114.304445
21. Patel MR, Peterson ED, Dai D, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. 2010;362(10):886-895. doi:10.1056/NEJMoa0907272
22. Taqueti VR, Hachamovitch R, Murthy VL, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation. 2015;131(1):19-27. doi:10.1161/CIRCULATIONAHA.114.011939
23. Shah NR, Cheezum MK, Veeranna V, et al. Ranolazine in Symptomatic Diabetic Patients Without Obstructive Coronary Artery Disease: Impact on Microvascular and Diastolic Function. J Am Heart Assoc. 2017;6(5):e005027. doi:10.1161/JAHA.116.005027
24. Shimokawa H. 2014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities-from bench to bedside. Eur Heart J. 2014;35(45):3180-3193. doi:10.1093/eurheartj/ehu427
25. Feher A, Sinusas AJ. Quantitative Assessment of Coronary Microvascular Function: Dynamic Single-Photon Emission Computed Tomography, Positron Emission Tomography, Ultrasound, Computed Tomography, and Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2017;10(8):e006427. doi:10.1161/CIRCIMAGING.117.006427
26. Gupta A, Taqueti VR, van de Hoef TP, et al. Integrated Noninvasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease. Circulation. 2017;136(24):2325-2336. doi:10.1161/CIRCULATIONAHA.117.029992
27. Doyle M, Weinberg N, Pohost GM, et al. Prognostic value of global MR myocardial perfusion imaging in women with suspected myocardial ischemia and no obstructive coronary disease: results from the NHLBI-sponsored WISE (Women’s Ischemia Syndrome Evaluation) study. JACC Cardiovasc Imaging. 2010;3(10):1030-1036. doi:10.1016/j.jcmg.2010.07.008
28. Ferreiro DE, Cianciulli TF, Saccheri MC, et al. Assessment of coronary flow with transthoracic color Doppler echocardiography in patients with hypertrophic cardiomyopathy. Echocardiogr Mt Kisco N. 2013;30(10):1156-1163. doi:10.1111/echo.12242
29. Ong P, Athanasiadis A, Borgulya G, et al. Clinical usefulness, angiographic characteristics, and safety evaluation of intracoronary acetylcholine provocation testing among 921 consecutive white patients with unobstructed coronary arteries. Circulation. 2014;129(17):1723-1730. doi:10.1161/CIRCULATIONAHA.113.004096
30. Modi BN, Rahman H, Sherif SA, et al. Is heart rate response a reliable marker of adenosine-induced coronary hyperemia? Int J Cardiovasc Imaging. 2018;34(7):1117-1125. doi:10.1007/s10554-018-1309-1
31. Pijls NHJ, Fearon WF, Tonino PAL, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol. 2010;56(3):177-184. doi:10.1016/j.jacc.2010.04.012
32. Layland J, Carrick D, McEntegart M, et al. Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv. 2013;6(3):231-236. doi:10.1161/CIRCINTERVENTIONS.112.000180
33. Berry C. Stable Coronary Syndromes: The Case for Consolidating the Nomenclature of Stable Ischemic Heart Disease. Circulation. 2017;136(5):437-439. doi:10.1161/CIRCULATIONAHA.117.028991
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