Comparative Evaluation of the Plaque and Gingivitis Reducing Efficacy of Chlorhexidine Diundecylinate (Salibact) and Triclosan Based Dentifrice: A Double Blind Randomized Controlled Trial
Main Article Content
Abstract
Background: Microbial complexity of biofilm indicate that streptocouss mutans and candida species lives in symbiotic relationship. The combination of antiplaque agent with antifungal agent can significantly influence the dental plaque. There is a search for effective antimicrobial agent in dentifrice formulation. chlorhexidine diundecylinate((CHUA) is novel antimicrobial agent introduced by salicylates and chemicals pvt ltd, has shown extended antimicrobial properties and are comparable to triclosan
Objectives: To evaluate and compare the plaque and gingivitis reducing efficacy of chlorhexidine Diundecylinate (salibact) and triclosan based dentifrice
Material and methods: A double blind randomized controlled trial was conducted among 86 subjects who are randomly divided into two groups. Experimental group received dentifrice containing chlorhexidine Diundecylinate with antidiscoloration system (salibact 0.1%+ ADS) and control group received 0.3% triclosan containing dentifrice.Plaque and gingival index scores were compared between baseline and six weeks.
Results: There is a significant difference between mean plaque index scores between salibact and triclosan containing dentifrice p(0.032)(0.015)<0.05 respectively. Mean plaque and gingivitis reduction was found to be better for salibact compared to triclosan
Conclusion: The study results provide some evidence that CHUA (Salibact) has definite role in plaque reduction and has better efficacy compared to triclosan. The new ingredient chlorhexidine diundecylenate seems to be a better choice as an efficient antimicrobial agent for the oral care dentifrice formulations.
Article Details
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
2. Yavnai N. [Toothpastes: ingredients, brands, categories and their utilization]. Refuat Hapeh Vehashinayim (1993). 2010 Apr;27(2):19-27, 61. Hebrew. PMID: 21250403.
3. Valkenburg C, Van der Weijden FA, Slot DE. Plaque control and reduction of gingivitis: The evidence for dentifrices. Periodontol 2000.
4. Sanz M, Serrano J, Iniesta M, Santa Cruz I, Herrera D. Antiplaque and antigingivitis toothpastes. Monogr Oral Sci. 2013;23:27–44.
5. Jones RD, Jampani HB, Newman JL, Lee AS. Triclosan: a review of effectiveness and safety in health care settings. Am J Infect Control. 2000
6. Trombelli L, Farina R. Efficacy of triclosan-based toothpastes in the prevention and treatment of plaque-induced periodontal and peri-implant diseases. Minerva Stomatol. 2013 Mar;62(3):71-88.
7. Feng HS, Pinheiro IC, Grande SR, Pannuti CM, Barros FJ, Lotufo RF. Effectiveness of a triclosan/copolymer dentifrice on dental plaque and gingivitis in Brazilian individuals with cerebral palsy. Spec Care Dentist. 2007 Jul-Aug;27(4):144-8.
8. Monteiro MF, Tonelli H, Reis AA, Casati MZ, Silvério KG, Nociti Junior FH, Sallum EA, Casarin RCV. Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial. Clin Oral Investig. 2020 Apr;24(4):1421-1430.
9. Niederman R. Triclosan-containing toothpastes reduce plaque and gingivitis. Evid Based Dent. 2005;6(2):33.
10. Weatherly LM, Gosse JA. Triclosan exposure, transformation, and human health effects. J Toxicol Environ Health B Crit Rev. 2017; 20(8):447-469.
11. Dhillon GS, Kaur S, Pulicharla R, Brar SK, Cledón M, Verma M, Surampalli RY. Triclosan: current status, occurrence, environmental risks and bioaccumulation potential. Int J Environ Res Public Health. 2015 May 22;12(5):5657-84.
12. Michael Goodman, Daniel Q. Naiman & Judy S. LaKind (2018) Systematic review of the literature on triclosan and health outcomes in humans, Critical Reviews in Toxicology, 48:1, 1-51
13. Witorsch RJ, Thomas JA. 2010. Personal care products and endocrine disruption: a critical review of the literature. Crit Rev Toxicol. 40:1–30.
14. Witorsch RJ. 2014. Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products. Crit Rev Toxicol. 44:535–555.
15. Lim KS. Chlorhexidine pharmacology and clinical applications anaesthetic intensive care. 2008; 36: 50-12
16. Johnson BT. Uses of chlorhexidine in dentistry. General Dentistry. 1995; 43: 126- 132 10. Hull P S. Chemical inhibition of plaque. Journal of Clinical Periodontology. 1980; 7: 431-442 11.
17. Johansen JR, Gjermo P, Eriksen HM. Effect of 2‐years’ use of chlorhexidine‐containing dentifrices on plaque, gingivitis, and caries. Scand J Dent Res. 1975;83:288–292.
18. Hioe KP, Van der Weijden GA. The effectiveness of self‐performed mechanical plaque control with triclosan containing dentifrices. Int J Dent Hyg. 2005;3:192–204.
19. Davies, R.M. The effect of topical application of chlorhexidine on the bacterial colonization of the teeth and gingiva. Periodontal Research.1970; 5: 96-101. 12.
20. Flotra, L, Gjenno, P., Rolla, G. et al. A 4-month study on the effect of chlorhexidine mouth washes on 50 soldiers. Scandinavian Journal of Dental Research. 1972; 80: 10-7.
21. Gjermo P and Rolla G. Plaque inhibition by antibacterial dentifrices. Scandinavian Journal of Dental Research. 1970; 78: 464-470.
22. Sanz M, Vallcorba N, Fabregues S, Muller I, Herkstr € €oter F. The effect of a dentifrice containing chlorhexidine and zinc on plaque,gingivitis, calculus and tooth staining. J Clin Periodontol 1994; 21:431–437.
23. Putt MS, Van der Weijden GA, Kleber CJ, Saxton CA. Validation of a 21‐day, partial‐mouth gingivitis model for evaluating chemotherapeutic dentifrices. J Periodontal Res. 1993;28:301–307.
24. Slot DE, Berchier CE, Addy M, Van der Velden U, Van der Weijden GA. The efficacy of chlorhexidine dentifrice or gel on plaque, clinical parameters of gingival inflammation and tooth discoloration: a systematic review. Int J Dent Hyg. 2014 Feb;12(1):25-35.
25. Addy M, Jenkins S, Newcombe R. Studies on the effect of toothpaste rinses on plaque regrowth. (I). Influence of surfactants on chlorhexidine efficacy. J Clin Periodontol. 1989;16:380–438.
26. de Carvalho FG, Silva DS, Hebling J, Spolidorio LC, Spolidorio DM. 2006. Presence of mutans streptococci and Candida spp. in dental plaque/dentine of carious teeth and early childhood caries. Arch. Oral Biol. 51:1024–1028.
27. Yang XQ, Zhang Q, Lu LY, Yang R, Liu Y, Zou J. 2012. Genotypic distribution of Candida albicans in dental biofilm of Chinese children associated with severe early childhood caries. Arch. Oral Biol. 57:1048–1053.