A Review of the Digestive, Respiratory and Nocioceptive Benefits, Associated Performance Outcomes and Clinical Considerations following Mint and Menthol application

Main Article Content

Russ Best

Abstract

Mint and to a lesser extent menthol have been used since antiquity for medicinal purposes. Key components of mint and menthol use such as composition and intake, safety and traditional uses are discussed prior to a review of clinical and human performance outcomes in the areas of digestive and respiratory health; antibacterial and anti-fungal properties, nocioception, migraine and headache and emerging evidence regarding COVID 19. Evidence suggests benefit for patients with irritable bowel syndrome and related digestive issues, with analgesic and respiratory effects also noted. Perceptual characteristics relating to thermal comfort and sensation, taste sensitivity and alertness are also considered; these effects are predominantly driven by stimulation of transient receptor potential melastatin 8 (TRPM8) activity resulting in sensations of cooling and freshness, with lesser influence on thirst. Finally, sport performance is considered as a domain that may further elucidate some of the aforementioned underpinning outcomes due to its systemic and dynamic nature, especially when performed in hot environmental conditions.

Keywords: Mint, Menthol, Digestion, Respiration, COVID-19, Sport, pain

Article Details

How to Cite
BEST, Russ. A Review of the Digestive, Respiratory and Nocioceptive Benefits, Associated Performance Outcomes and Clinical Considerations following Mint and Menthol application. Medical Research Archives, [S.l.], v. 11, n. 1, jan. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3321>. Date accessed: 18 apr. 2024. doi: https://doi.org/10.18103/mra.v11i1.3321.
Section
Review Articles

References

1. Mahendran G, Rahman L. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)—A review. Phytother Res. 2020;34(9):2088-2139. doi:10.1002/ptr.6664
2. Spirling LI, Daniels IR. Botanical perspectives on health Peppermint: more than just an after-dinner mint. J Royal Soc Promot Heal. 2001;121(1):62-63. doi:10.1177/146642400112100113
3. Kamatou GPP, Vermaak I, Viljoen AM, Lawrence BM. Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry. 2013;96(C):15-25. doi:10.1016/j.phytochem.2013.08.005
4. Potter FH. THE USE OF MENTHOL IN DISEASES OF THE UPPER AIR-PASSAGES.: Read in the Section of Laryngology and Otology, at the Fortieth Annual Meeting of the American Medical Association, Journal of the American Medical Association. 1890;14(5):147-149.
5. Somers LS. the use of menthol in pharyngitis. The Laryngoscope. 1896;1(2):78-82. https://twin.sci-hub.tw/5658/9d36f7854875e8d7e1adb54514e2bc/somers1896.pdf
6. Eccles R. Menthol and Related Cooling Compounds. Journal of Pharmacy and Pharmacology. 1994;46(8):618-630. doi:10.1111/j.2042-7158.1994.tb03871.x
7. Eccles R. Role of cold receptors and menthol in thirst, the drive to breathe and arousal. Appetite. 2000;34(1):29-35. doi:10.1006/appe.1999.0291
8. Eccles R, Du-Plessis L, Dommels Y, Wilkinson JE. Cold pleasure. Why we like ice drinks, ice-lollies and ice cream. Appetite. 2013;71(C):357-360. doi:10.1016/j.appet.2013.09.011
9. Kalantzis A, Robinson PP, Loescher AR. Effects of capsaicin and menthol on oral thermal sensory thresholds. Archives of Oral Biology. 2007;52(2):149-153. doi:10.1016/j.archoralbio.2006.09.001
10. Nazıroğlu M, Özgül C. Effects of Antagonists and Heat on TRPM8 Channel Currents in Dorsal Root Ganglion Neuron Activated by Nociceptive Cold Stress and Menthol. Neurochemical Research. 2011;37(2):314-320. doi:10.1007/s11064-011-0614-z
11. Nilius B, Owsianik G. The transient receptor potential family of ion channels. Genome biology. 2011;12(3):218. doi:10.1186/gb-2011-12-3-218
12. Galeotti N, Mannelli LDC, Mazzanti G, Bartolini A, Ghelardini C. Menthol: a natural analgesic compound. Neuroscience letters. 2002;322(3):145-148.
13. Gaudioso C, Hao J, Martin-Eauclaire MF, Gabriac M, Delmas P. Menthol pain relief through cumulative inactivation of voltage-gated sodium channels. Pain. 2012;153(2):473-484. doi:10.1016/j.pain.2011.11.014
14. Watson HR, Hems R, Rowsell DG, Spring DJ. New compounds with the menthol cooling effect. Journal of the Society of Cosmetic Chemists. 1978;29:185-200.
15. Best R, Crosby S, Berger N, McDonald K. The Effect of Isolated and Combined Application of Menthol and Carbohydrate Mouth Rinses on 40 km Time Trial Performance, Physiological and Perceptual Measures in the Heat. Nutrients. 2021;13(12):4309. doi:10.3390/nu13124309
16. Best R, Maulder PS, Berger N. Perceptual and Physiological Responses to Carbohydrate and Menthol Mouth-Swilling Solutions: A Repeated Measures Cross-Over Preliminary Trial. Beverages. 2021;7(1):9. doi:10.3390/beverages7010009
17. Rezaeinia H, Ghorani B, Emadzadeh B, Mohebbi M. Prolonged-release of menthol through a superhydrophilic multilayered structure of balangu (Lallemantia royleana)-gelatin nanofibers. Mater Sci Eng C. 2020;115:111115. doi:10.1016/j.msec.2020.111115
18. Chen L, Ma L, Yang S, et al. A multiscale study of the penetration-enhancing mechanism of menthol. J Traditional Chin Medical Sci. 2019;6(4):347-354. doi:10.1016/j.jtcms.2019.10.001
19. Best R, Payton S, Spears I, Riera F, Berger N. Topical and Ingested Cooling Methodologies for Endurance Exercise Performance in the Heat. Sports. 2018;6(1):11-11. doi:10.3390/sports6010011
20. Gelal A, Jacob P, Yu L, Benowitz NL. Disposition kinetics and effects of menthol. Clinical Pharmacology & Therapeutics. 1999;66(2):128-135. doi:10.1053/cp.1999.v66.100455001
21. Hensel H, Zotterman Y. The effect of menthol on the thermoreceptors. Acta Physiologica Scandinavica. 1951;24(1):27-34. doi:10.1111/j.1748-1716.1951.tb00824.x
22. Schwenkenbecher, Inagaki. Ueber den Wasserwechsel des fiebernden Menschen. Archiv Für Exp Pathologie Und Pharmakologie. 1906;54(3):168-195. doi:10.1007/bf01838763
23. Nath S, Pandey C, Roy D. A near fatal case of high dose peppermint oil ingestion- Lessons learnt. Indian J Anaesth. 2012;56(6):582. doi:10.4103/0019-5049.104585
24. Baibars M, Eng S, Shaheen K, Alraiyes AH, Alraies MC. Menthol toxicity: an unusual cause of coma. Case Reports Medicine. 2012;2012:187039. doi:10.1155/2012/187039
25. Behrends M, Beiderlinden M, Peters J. Acute Lung Injury After Peppermint Oil Injection. Anesthesia Analgesia. 2005;101(4):1160-1162. doi:10.1213/01.ane.0000175774.33435.87
26. Nair B. Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. Int J Toxicol. 2001;20 Suppl 3:61-73.
27. Kligler B, Chaudhary S. Peppermint oil. Am Fam Physician. 2007;75(7):1027-1030.
28. Kumar A, Baitha U, Aggarwal P, Jamshed N. A fatal case of menthol poisoning. International Journal of Applied and Basic Medical Research. 2016;6(2):137-5. doi:10.4103/2229-516x.179015
29. Lee JY, Nakao K, Bakri I, Tochihara Y. Body regional influences of L-menthol application on the alleviation of heat strain while wearing firefighter’s protective clothing. European Journal of Applied Physiology. 2012;112(6):2171-2183. doi:10.1007/s00421-011-2192-9
30. Schlader ZJ, Simmons SE, Stannard SR, Mündel T. The independent roles of temperature and thermal perception in the control of human thermoregulatory behavior. Physiology & Behavior. 2011;103(2):217-224. doi:10.1016/j.physbeh.2011.02.002
31. Stevens CJ, Best R. Menthol: A Fresh Ergogenic Aid for Athletic Performance. Sports Medicine. 2017;47(6):1035-1042. doi:10.1007/s40279-016-0652-4
32. Barwood MJ, Gibson OR, Gillis DJ, et al. Menthol as an Ergogenic Aid for the Tokyo 2021 Olympic Games: An Expert-Led Consensus Statement Using the Modified Delphi Method. Sports Medicine. Published online July 1, 2020:1-19. doi:10.1007/s40279-020-01313-9
33. Alammar N, Wang L, Saberi B, et al. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. Published online January 16, 2019:1-10. doi:10.1186/s12906-018-2409-0
34. Ford AC, Talley NJ, Spiegel BMR, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. Bmj. 2008;337(nov13 2):a2313. doi:10.1136/bmj.a2313
35. Kline RM, Kline JJ, J DP, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. The Journal of pediatrics. 2001;138(1):125-128.
36. Lane B, Cannella K, Bowen C, et al. Examination of the Effectiveness of Peppermint Aromatherapy on Nausea in Women Post C-Section. Journal of Holistic Nursing. 2012;30(2):90-104. doi:10.1177/0898010111423419
37. Tate S. Peppermint oil: a treatment for postoperative nausea. Journal of advanced nursing. 1997;26(3):543-549.
38. Shavakhi A, Ardestani SK, Taki M, Goli M, Keshteli AH. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta gastro-enterologica Belgica. 2012;75(3):349-353.
39. Inamori M, Akiyama T, Akimoto K, et al. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system). Journal of Gastroenterology. 2007;42(7):539-542. doi:10.1007/s00535-007-2067-3
40. Holzer P. Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacology and Therapeutics. 2011;131(1):142-170. doi:10.1016/j.pharmthera.2011.03.006
41. Burrow A, Eccles R, Jones AS. The effects of camphor, eucalyptus and menthol vapour on nasal resistance to airflow and nasal sensation. Acta Oto-laryngol. 1983;96(1-2):157-161. doi:10.3109/00016488309132886
42. Eccles R, Morris S, Jawad MSM. The effects of menthol on reaction time and nasal sensation of airflow in subjects suffering from the common cold. Clin Otolaryngology Allied Sci. 1990;15(1):39-42. doi:10.1111/j.1365-2273.1990.tb00430.x
43. Sloan A, Cort SCD, Eccles R. Prolongation of breath-hold time following treatment with an L-menthol lozenge in healthy man. The Journal of Physiology. 473:53.
44. Eccles R. Menthol: Effects on nasal sensation of airflow and the drive to breathe. Current allergy and asthma reports. 2003;3(3):210-214. doi:10.1007/s11882-003-0041-6
45. Nishino T, Tagaito Y, Sakurai Y. Nasal Inhalation of l-menthol Reduces Respiratory Discomfort Associated with Loaded Breathing. American Journal of Respiratory and Critical Care Medicine. 1997;156(1):309-313. doi:10.1164/ajrccm.156.1.9609059
46. Tsutsumi Y, Momma H, Ebihara S, Nagatomi R. L-menthol administration facilitates breathing comfort during exhaustive endurance running and improves running capacity in well-trained runners: A randomized crossover study. Eur J Sport Sci. Published online 2022:1-25. doi:10.1080/17461391.2022.2115404
47. Kanezaki M, Ebihara S. Effect of the cooling sensation induced by olfactory stimulation by L-menthol on dyspnoea: a pilot study. Eur Respir J. 2017;49(4):1601823. doi:10.1183/13993003.01823-2016
48. Naito K, Komori M, Kondo Y, Takeuchi M, Iwata S. The effect of l-menthol stimulation of the major palatine nerve on subjective and objective nasal patency. Auris Nasus Larynx. 1997;24(2):159-162. doi:10.1016/s0385-8146(96)00005-3
49. Jones AS, Willatt DJ, Durham LM. Nasal airflow: resistance and sensation. J Laryngology Otology. 1989;103(10):909-911. doi:10.1017/s0022215100110485
50. Gavliakova S, Buday T, Shetthalli VM, Plevkova J. Analysis of pathomechanisms involved in side effects of menthol treatment in respiratory diseases. Open J Mol Integr Physiology. 2013;03(01):21-26. doi:10.4236/ojmip.2013.31004
51. Plevkova J, Kollarik M, Poliacek I, et al. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. J Appl Physiol. 2013;115(2):268-274. doi:10.1152/japplphysiol.01144.2012
52. Viana F. Chemosensory Properties of the Trigeminal System. ACS Chemical Neuroscience. 2011;2(1):38-50. doi:10.1021/cn100102c
53. Chuang H hu, Neuhausser WM, Julius D. The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel. Neuron. 2004;43(6):859-869. doi:10.1016/j.neuron.2004.08.038
54. Knowlton WM, Bifolck-Fisher A, Bautista DM, McKemy DD. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain. 2010;150(2):340-350. doi:10.1016/j.pain.2010.05.021
55. Morgan K, Sadofsky LR, Crow C, Morice AH. Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Bioscience reports. 2014;34(4):469-478. doi:10.1042/bsr20140061
56. Kanezaki M, Terada K, Ebihara S. Effect of Olfactory Stimulation by L-Menthol on Laboratory-Induced Dyspnea in COPD. Chest. 2020;157(6):1455-1465. doi:10.1016/j.chest.2019.12.028
57. Kanezaki M, Terada K, Ebihara S. l-Menthol – a new treatment for breathlessness? Curr Opin Support Pa. 2021;15(4):233-238. doi:10.1097/spc.0000000000000569
58. Liss HP, Grant BJB. The Effect of Nasal Flow on Breathlessness in Patients with Chronic Obstructive Pulmonary Disease. Am Rev Respir Dis. 1988;137(6):1285-1288. doi:10.1164/ajrccm/137.6.1285
59. Mündel T, Jones DA. The effects of swilling an l(−)-menthol solution during exercise in the heat. European Journal of Applied Physiology. 2009;109(1):59-65. doi:10.1007/s00421-009-1180-9
60. Stevens CJ, Mauger AR, Hassmèn P, Taylor L. Endurance Performance is Influenced by Perceptions of Pain and Temperature: Theory, Applications and Safety Considerations. Sports Medicine. Published online December 21, 2017:1-14. doi:10.1007/s40279-017-0852-6
61. Soeda M, Ohka S, Nishizawa D, et al. Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2 / F2RL1 and TRPM8. Mol Pain. 2021;17:174480692110020. doi:10.1177/17448069211002009
62. Craig ADB. Interoception: the sense of the physiological condition of the body. Current opinion in neurobiology. 2003;13(4):500-505. doi:10.1016/s0959-4388(03)00090-4
63. Craig ADB. How do you feel--now? The anterior insula and human awareness. Nature reviews neuroscience. 2009;10(1):59-70. doi:10.1038/nrn2555
64. Gillis DJ, Vellante A, Gallo JA, DʼAmico AP. Influence of Menthol on Recovery From Exercise-Induced Muscle Damage. Journal of strength and conditioning research / National Strength & Conditioning Association. Published online August 29, 2018. doi:10.1519/jsc.0000000000002833
65. Topp R, Ledford ER, Jacks DE. Topical Menthol, Ice, Peripheral Blood Flow, and Perceived Discomfort. Journal of Athletic Training. 2013;48(2):220-225. doi:10.4085/1062-6050-48.1.19
66. Topp R, Winchester LJ, Schilero J, Jacks D. Effect of topical menthol on ipsilateral and contralateral superficial blood flow following a bout of maximum voluntary muscle contraction. International journal of sports physical therapy. 2011;6(2):83-91.
67. Fallon MT, Storey DJ, Krishan A, et al. Cancer treatment-related neuropathic pain: proof of concept study with menthol—a TRPM8 agonist. Support Care Cancer. 2015;23(9):2769-2777. doi:10.1007/s00520-015-2642-8
68. Kraemer WJ, Ratamess NA, Maresh CM, et al. A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. J Strength Cond Res. 2005;19(2):475-480. doi:10.1519/r-505059.1
69. Mahieu F, Owsianik G, Verbert L, et al. TRPM8-independent Menthol-induced Ca2+ Release from Endoplasmic Reticulum and Golgi. Journal of Biological Chemistry. 2007;282(5):3325-3336.
70. Botonis PG, Geladas ND, Kounalakis SN, Cherouveim ED, Koskolou MD. Effects of menthol application on the skin during prolonged immersion in swimmers and controls. Journal of Applied Physiology. 2016;27(12):1560-1568. doi:10.1111/sms.12799
71. Ling YH, Chen SP, Fann CSJ, Wang SJ, Wang YF. TRPM8 genetic variant is associated with chronic migraine and allodynia. J Headache Pain. 2019;20(1):115. doi:10.1186/s10194-019-1064-2
72. Siegel R, Laursen PB. Keeping Your Cool. Sports Medicine. 2012;42(2):89-98. doi:10.2165/11596870-000000000-00000
73. Best R. MENTHOL MOUTH SWILLING AND ENDURANCE RUNNING PERFORMANCE IN THE HEAT. Published online August 1, 2019.
74. Finsterer J, Scorza FA, Scorza CA, Fiorini AC. COVID-19 associated cranial nerve neuropathy: A systematic review. Bosnian J Basic Med. 2022;22(1):39-45. doi:10.17305/bjbms.2021.6341
75. Aiyegbusi OL, Hughes SE, Turner G, et al. Symptoms, complications and management of long COVID: a review. J Roy Soc Med. 2021;114(9):428-442. doi:10.1177/01410768211032850
76. Carfì A, Bernabei R, Landi F, Group GAC 19 PACS. Persistent Symptoms in Patients After Acute COVID-19. Jama. 2020;324(6):603-605. doi:10.1001/jama.2020.12603
77. Sykes DL, Holdsworth L, Jawad N, Gunasekera P, Morice AH, Crooks MG. Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It? Lung. 2021;199(2):113-119. doi:10.1007/s00408-021-00423-z
78. Mermelstein S. Acute anosmia from COVID-19 infection. Pract Neurology. 2020;20(4):343-344. doi:10.1136/practneurol-2020-002583
79. Messlinger K, Neuhuber W, May A. Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19. Cephalalgia. 2022;42(2):176-180. doi:10.1177/03331024211036665
80. Saniasiaya J, Islam MA, Abdullah B. Prevalence and Characteristics of Taste Disorders in Cases of COVID-19: A Meta-analysis of 29,349 Patients. Otolaryngology Head Neck Surg. 2020;165(1):33-42. doi:10.1177/0194599820981018
81. Frasnelli J, Albrecht J, Bryant B, Lundström JN. Perception of specific trigeminal chemosensory agonists. Neuroscience. 2011;189:377-383. doi:10.1016/j.neuroscience.2011.04.065
82. Reed DR, Knaapila A. Genetics of Taste and Smell. In: Vol 94. Genes and Obesity. Elsevier; 2010:213-240. doi:10.1016/b978-0-12-375003-7.00008-x
83. Jaffal SM, Abbas MA. TRP channels in COVID-19 disease: Potential targets for prevention and treatment. Chem-biol Interact. 2021;345:109567-109567. doi:10.1016/j.cbi.2021.109567
84. Douaud G, Lee S, Alfaro-Almagro F, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022;604(7907):697-707. doi:10.1038/s41586-022-04569-5
85. Molina‐Gil J, González‐Fernández L, García‐Cabo C. Trigeminal neuralgia as the sole neurological manifestation of COVID‐19: A case report. Headache J Head Face Pain. 2021;61(3):560-562. doi:10.1111/head.14075
86. Valussi M, Antonelli M, Donelli D, Firenzuoli F. Appropriate use of essential oils and their components in the management of upper respiratory tract symptoms in patients with COVID-19. J Herb Med. 2021;28:100451-100451. doi:10.1016/j.hermed.2021.100451
87. Parsa S, Mogharab V, Ebrahimi M, et al. COVID-19 as a worldwide selective event and bitter taste receptor polymorphisms: An ecological correlational study. Int J Biol Macromol. 2021;177:204-210. doi:10.1016/j.ijbiomac.2021.02.070
88. Cameron EL. Olfactory perception in children. World Journal of Otorhinolaryngology-Head and Neck Surgery. 2018;4(1):57-66. doi:10.1016/j.wjorl.2018.02.002
89. Cometto-Muñiz JE, Cain WS. Thresholds for odor and nasal pungency. Physiology & Behavior. 1990;48(5):719-725. doi:10.1016/0031-9384(90)90217-r
90. Holzer P. Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacology and Therapeutics. 2011;131(1):142-170. doi:10.1016/j.pharmthera.2011.03.006
91. Dicks MA, Clements ND, Gibbons CR, Verduzco-Gutierrez M, Trbovich M. Atypical presentation of Covid-19 in persons with spinal cord injury. Spinal Cord Ser Cases. 2020;6(1):38. doi:10.1038/s41394-020-0289-2
92. Jeffries O, Waldron M. The effects of menthol on exercise performance and thermal sensation: A meta-analysis. Journal of Science and Medicine in Sport. 2019;22(6):707-715. doi:10.1016/j.jsams.2018.12.002
93. Key FM, Abdul-Aziz MA, Mundry R, et al. Human local adaptation of the TRPM8 cold receptor along a latitudinal cline. Gojobori T, ed. PLOS Genetics. 2018;14(5):e1007298-22. doi:10.1371/journal.pgen.1007298
94. Frasnelli J, Hummel T. Age-related decline of intranasal trigeminal sensitivity: is it a peripheral event? Brain Res. 2003;987(2):201-206. doi:10.1016/s0006-8993(03)03336-5
95. Waldock KAM, Hayes M, Watt PW, Maxwell NS. The elderly’s physiological and perceptual responses to cooling during simulated activities of daily living in UK summer climatic conditions. Public Health. 2021;193:1-9. doi:10.1016/j.puhe.2021.01.016
96. Millyard A, Layden JD, Pyne DB, Edwards AM, Bloxham SR. Impairments to Thermoregulation in the Elderly During Heat Exposure Events. Gerontology Geriatric Medicine. 2020;6:2333721420932432. doi:10.1177/2333721420932432
97. Jay O, Capon A, Berry P, et al. Reducing the health effects of hot weather and heat extremes: from personal cooling strategies to green cities. Lancet. 2021;398(10301):709-724. doi:10.1016/s0140-6736(21)01209-5
98. Bunker A, Wildenhain J, Vandenbergh A, et al. Effects of Air Temperature on Climate-Sensitive Mortality and Morbidity Outcomes in the Elderly; a Systematic Review and Meta-analysis of Epidemiological Evidence. Ebiomedicine. 2016;6:258-268. doi:10.1016/j.ebiom.2016.02.034
99. Parton AJ, Waldron M, Clifford T, Jeffries O. Thermo-behavioural responses to orally applied L-menthol exhibit sex-specific differences during exercise in a hot environment. Physiol Behav. Published online 2020:113250. doi:10.1016/j.physbeh.2020.113250
100. Gavel EH, Logan-Sprenger HM, Good J, Jacobs I, Thomas SG. Menthol Mouth Rinsing and Cycling Performance in Females Under Heat Stress. Int J Sport Physiol. 2021;16(7):1014-1020. doi:10.1123/ijspp.2020-0414
101. Gillis DJ, Weston N, House JR, Tipton MJ. Influence of repeated daily menthol exposure on human temperature regulation and perception. Physiology & Behavior. 2015;139:511-518. doi:10.1016/j.physbeh.2014.12.009
102. Leterme A, Brun L, Dittmar A, Robin O. Autonomic nervous system responses to sweet taste: Evidence for habituation rather than pleasure. Physiology & Behavior. 2008;93(4-5):994-999. doi:10.1016/j.physbeh.2008.01.005
103. Lee JKW, Tan B, Ogden HB, Chapman S, Sawka MN. Exertional heat stroke: nutritional considerations. Exp Physiol. 2022;107(10):1122-1135. doi:10.1113/ep090149
104. Zhang Y, Balilionis G, Casaru CM, et al. Effect of Menthol on Respiratory and Perceptual Responses to Exercise in Firefighter Protective Gear. Montenegrin Journal of Sports Science and Medicine. 4(2):29-34.
105. Bongers CC, Korte JQ de, Catoire M, et al. Infographic. Cooling strategies to attenuate PPE-induced heat strain during the COVID-19 pandemic. Brit J Sport Med. 2021;55(1):69-70. doi:10.1136/bjsports-2020-102528
106. Bongers CCWG, Korte JQ de, Zwartkruis M, Levels K, Kingma BRM, Eijsvogels TMH. Heat Strain and Use of Heat Mitigation Strategies among COVID-19 Healthcare Workers Wearing Personal Protective Equipment—A Retrospective Study. Int J Environ Res Pu. 2022;19(3):1905. doi:10.3390/ijerph19031905
107. Korte JQ de, Bongers CCWG, Catoire M, Kingma BRM, Eijsvogels TMH. Cooling vests alleviate perceptual heat strain perceived by COVID-19 nurses. Temp. 2021;9(1):1-11. doi:10.1080/23328940.2020.1868386
108. Barwood MJ, Corbett J, Thomas K, Twentyman P. Relieving thermal discomfort: Effects of sprayed L-menthol on perception, performance, and time trial cycling in the heat. Journal of Applied Physiology. 2015;25:211-218. doi:10.1111/sms.12395
109. Barwood MJ, Corbett J, White D, James J. Early change in thermal perception is not a driver of anticipatory exercise pacing in the heat. British Journal of Sports Medicine. 2012;46(13):936-942. doi:10.1136/bjsports-2011-090536
110. Barwood MJ, Corbett J, White DK. Spraying with 0.20% L-menthol does not enhance 5 km running performance in the heat in untrained runners. The Journal of sports medicine and physical fitness. 2014;54(5):595-604.
111. Barwood MJ, Kupusarevic J, Goodall S. Enhancement of Exercise Capacity in the Heat With Repeated Menthol-Spray Application. International journal of sports physiology and performance. 2019;14(5):644-649. doi:10.1123/ijspp.2018-0561
112. Gillis DJ, Barwood MJ, Newton PS, House JR, Tipton MJ. The influence of a menthol and ethanol soaked garment on human temperature regulation and perception during exercise and rest in warm, humid conditions. Journal of Thermal Biology. 2016;58(C):99-105. doi:10.1016/j.jtherbio.2016.04.009
113. Riera F, Trong TT, Sinnapah S, Hue O. Physical and Perceptual Cooling with Beverages to Increase Cycle Performance in a Tropical Climate. Hayashi N, ed. PLoS ONE. 2014;9(8):e103718-7. doi:10.1371/journal.pone.0103718
114. Trong TT, Riera F, Rinaldi K, Briki W, Hue O. Ingestion of a cold temperature/menthol beverage increases outdoor exercise performance in a hot, humid environment. Romanovsky AA, ed. PLoS ONE. 2015;10(4):e0123815. doi:10.1371/journal.pone.0123815
115. Riera F, Trong T, Rinaldi K, Hue O. Precooling does not Enhance the Effect on Performance of Midcooling with Ice-Slush/Menthol. International journal of sports medicine. 2016;37(13):1025-1031. doi:10.1055/s-0042-107597
116. Flood TR, Waldron M, Jeffries O. Oral L-menthol reduces thermal sensation, increases work-rate and extends time to exhaustion, in the heat at a fixed rating of perceived exertion. European Journal of Applied Physiology. 2017;117(7):1501-1512. doi:10.1007/s00421-017-3645-6
117. Green BG. Menthol modulates oral sensations of warmth and cold. Physiology & Behavior. 1985;35(3):427-434.
118. Jeffries O, Goldsmith M, Waldron M. L-Menthol mouth rinse or ice slurry ingestion during the latter stages of exercise in the heat provide a novel stimulus to enhance performance despite elevation in mean body temperature. European Journal of Applied Physiology. 2018;118(11):2435-2442. doi:10.1007/s00421-018-3970-4
119. Schlader ZJ, Stannard SR, Mündel T. Evidence for thermoregulatory behavior during self-paced exercise in the heat. Journal of Thermal Biology. 2011;36(7):390-396. doi:10.1016/j.jtherbio.2011.07.002
120. Stevens CJ, Bennett KJM, Sculley DV, Callister R, Taylor L, Dascombe BJ. A comparison of mixed-method cooling interventions on pre-loaded running performance in the heat. The Journal of Strength & Conditioning Research. Published online June 2016:1-28. doi:10.1519/jsc.0000000000001532
121. Stevens CJ, Thoseby B, Sculley DV, Callister R, Taylor L, Dascombe BJ. Running performance and thermal sensation in the heat are improved with menthol mouth rinse but not ice slurry ingestion. Scandinavian Journal of Medicine and Science in Sports. 2016;26(10):1209-1216. doi:10.1111/sms.12555
122. Best R, Naicker R, Maulder P, Berger N. Dilution Method of Menthol Solutions Affects Subsequent Perceptual Thermal Responses during Passive Heat Exposure in Non-Heat Acclimated Participants. Beverages. 2021;7(3):62. doi:10.3390/beverages7030062
123. Best R, Temm D, Hucker H, McDonald K. Repeated Menthol Mouth Swilling Affects Neither Strength nor Power Performance. Sports. 2020;8(6):90-12. doi:10.3390/sports8060090
124. Crosby S, Butcher A, McDonald K, Berger N, Bekker PJ, Best R. Menthol Mouth Rinsing Maintains Relative Power Production during Three-Minute Maximal Cycling Performance in the Heat Compared to Cold Water and Placebo Rinsing. Int J Environ Res Pu. 2022;19(6):3527. doi:10.3390/ijerph19063527
125. Gibson OR, Wrightson JG, Hayes M. Intermittent sprint performance in the heat is not altered by augmenting thermal perception via L-menthol or capsaicin mouth rinses. European Journal of Applied Physiology. 2018;46(Suppl 1):936-12. doi:10.1007/s00421-018-4055-0
124. Serato VM, Fonseca LF, Birolim MM, Rossetto EG, Mai LD, Garcia AKA. Package of menthol measures for thirst relief: a randomized clinical study. Revista Brasileira De Enfermagem. 2019;72(3):600-608. doi:10.1590/0034-7167-2018-0057
125. Klein AH, Carstens MI, Zanotto KL, et al. Self- and cross-desensitization of oral irritation by menthol and cinnamaldehyde (CA) via peripheral interactions at trigeminal sensory neurons. Chemical Senses. 2011;36(2):199-208. doi:10.1093/chemse/bjq115
126. Patel T, Ishiuji Y, Yosipovitch G. Menthol: A refreshing look at this ancient compound. Journal of the American Academy of Dermatology. 2007;57(5):873-878. doi:10.1016/j.jaad.2007.04.008