Heart Failure Due to Idiopathic Hypereosinophilic Syndrome in Pregnancy: A Case Report and Review of the Literature

Main Article Content

Ali Mert, Prof. Selda Aydin, Associate Prof.

Abstract

Background: Hypereosinophilic syndrome is defined as the sustained overproduction of eosinophils leading to the dysfunction of one or more organs. Most of the deaths associated with Hypereosinophilic syndrome are related to cardiac involvement.


Case Presentation: We present the case of a 32-year-old woman who became pregnant during her follow-up period for her diagnosis of HES with cardiac involvement. She was treated successfully with a combination of IFN-alfa and prednisolone. She underwent an elective C-section at 39 weeks and delivered a healthy infant weighing 3400g. The patient died due to a complicated intra-abdominal infection secondary to colon perforation at 8 years of illness and 4 years of giving birth.


Conclusion: We reviewed the literature on the best treatment modalities for this challenging issue. Management of idiopathic HES causing severe heart failure during pregnancy can be achieved using steroids and interferon-α.

Keywords: Idıopathic Hypereosinophilic Syndrome, Pregnancy, Heart Failure

Article Details

How to Cite
MERT, Ali; AYDIN, Selda. Heart Failure Due to Idiopathic Hypereosinophilic Syndrome in Pregnancy: A Case Report and Review of the Literature. Medical Research Archives, [S.l.], v. 10, n. 11, nov. 2022. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3330>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.18103/mra.v10i11.3330.
Section
Review Articles

References

1. Shomali W, Gotlib J. World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. Jan 1 2022;97(1):129-148. doi:10.1002/ajh.26352
2. Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore). Jan 1975;54(1):1-27.
3. Valent P, Klion AD, Horny HP, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. Sep 2012;130(3):607-612 e9. doi:10.1016/j.jaci.2012.02.019
4. Ruan GJ, Smith CJ, Day C, et al. A population-based study of chronic eosinophilic leukemia-not otherwise specified in the United States. Am J Hematol. Jun 13 2020;doi:10.1002/ajh.25906
5. Requena G, van den Bosch J, Akuthota P, et al. Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review. J Allergy Clin Immunol Pract. Aug 2022;10(8):2125-2134. doi:10.1016/j.jaip.2022.03.034
6. Rothenberg ME. Eosinophilia. N Engl J Med. May 28 1998;338(22):1592-600. doi:10.1056/NEJM199805283382206
7. Roufosse F, Klion AD, Weller PF. Hypereosinophilic syndromes: Treatment. Uptodate 2022.
8. Roufosse F, Klion AD, Weller PF. Hypereosinophilic syndromes: Clinical manifestations, pathophysiology, and diagnosis. 2022.
9. Albrecht AE, Hartmann BW, Kurz C, Cartes F, Husslein PW. Idiopathic hypereosinophilic syndrome and pregnancy. Acta Obstet Gynecol Scand. May 1997;76(5):485-6. doi:10.3109/00016349709047834
10. Ault P, Cortes J, Lynn A, Keating M, Verstovsek S. Pregnancy in a patient with hypereosinophilic syndrome. Leuk Res. Jan 2009;33(1):186-7. doi:10.1016/j.leukres.2008.05.013
11. Darki A, Kodali PP, McPheters JP, Virk H, Patel MR, Jacobs W. Hypereosinophilic syndrome with cardiac involvement in a pregnant patient with multiple sclerosis. Tex Heart Inst J. 2011;38(2):163-5.
12. Pineton de Chambrun M, Charron P, Vauthier-Brouzes D, et al. Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report. Medicine (Baltimore). Aug 2015;94(32):e1307. doi:10.1097/MD.0000000000001307
13. Curtis C, Ogbogu P. Hypereosinophilic Syndrome. Clin Rev Allergy Immunol. Apr 2016;50(2):240-51. doi:10.1007/s12016-015-8506-7
14. Kuang FL, Klion AD. Biologic Agents for the Treatment of Hypereosinophilic Syndromes. J Allergy Clin Immunol Pract. Nov - Dec 2017;5(6):1502-1509. doi:10.1016/j.jaip.2017.08.001
15. Shakuntulla F, Chiarella SE. Safety of biologics for atopic diseases during pregnancy. J Allergy Clin Immunol Pract. Aug 17 2022;doi:10.1016/j.jaip.2022.08.013