Growth Factors and Effects of Palifermin in Management of Cancer Therapy Induced Oral Mucositis
Main Article Content
Abstract
Amongst the various hazards of chemotherapeutic drugs and radiation in cancer patients, oral mucositis is the most commonly encountered and troublesome complication so far. It can be a cause for discontinuation of therapy and may add to the cost of treatment. In this article, pathogenesis of oral mucositis and role of recombinant human growth factors in management of it have been discussed, as we need to achieve a guideline for proper treatment of this painful side effect of cancer treatment. Palifermin, a keratinocyte growth factor has been shown to give promising results in cases of severe mucositis in hematopoetic stem cell transplant patients undergoing combined chemoradiotherapy. Other exogenous growth factors are also effective in the management of mucositis when administered topically or subcutaneously, but there is need for more number of studies with a large sample size for establishing a proper treatment plan which is cost effective as well as helpful in reducing patient’s discomfort.
Keywords: Chemotherapy, Radiotherapy, Growth factors, Oral Mucositis, Hematopoietic stem cell transplant.
Keywords:
Chemotherapy, Radiotherapy, Growth factors, Oral Mucositis, Hematopoietic stem cell transplant
Article Details
How to Cite
SHRIVASTAVA, Noopur.
Growth Factors and Effects of Palifermin in Management of Cancer Therapy Induced Oral Mucositis.
Medical Research Archives, [S.l.], v. 10, n. 11, nov. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3349>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.18103/mra.v10i11.3349.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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2. Rzepecki P, Oborska S, Wasko-Grabowska A, Mlot B, Barzal J. Pharmacotherapy of oral mucositis with Palifermin. Clinical Medicine: Therapeutics. 2009;1: 333-342.
3. Rodriguez- Caballero A, Torres- Lagares D, Robles- Garcia M, Pachon- Ibanez J, Gonzalez- Padilla D, Gutierrez- Perez JL. Cancer treatment- induced oral mucositis: a critical review. Int J Oral Maxillofac Surg. 2012; 41(2): 225-238.
4. Epstein JB, Gorsky M, Guglietta A, Le N, Sonis ST. The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy. Cancer.2000; 89 (11): 2258-2265.
5. Girdler NM, McGurk M, Aqual S, Prince M. The effect of epidermal growth factor mouthwash on cytotoxic- induced oral ulceration. A Phase I clinical trial. Am J Clin Oncol. 1995; 18: 403-6.
6. Epstein JB, Emerton S, Guglietta A, Le N. Assessment of epidermal growth factor in oral secretions of patients receiving radiation therapy for cancer. Oral Oncol. 1997; 33: 359-63.
7. Sonis ST, Costa JW Jr., Evitts SM, Lindquist LE, Nicolson M. Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy. Oral Surg Oral Med Oral Pathol. 1992; 74: 749-55.
8. Hong JP, Lee SW, Song SY, Ahn SD, Shin SS, Choi EK, Kim JH. Recombinant human epidermal growth factor treatment of radiation- induced severe oral mucositis in patients with head and neck malignancies. European Journal of Cancer Care. 2009; 18: 636-41.
9. Kim KI, Kim JW, Lee HJ, Kim BS, Bang SM, Kim I et al. Recombinant human epidermal growth factor on oral mucositis induced by intensive chemotherapy with stem cell transplantation. Am J Hematol. 2013; 88: 107-112.
10. Kim JW, Kim MG, Lee HJ, Koh Y, Kwon JH, Kim I et al. Topical recombinant human epidermal growth factor for oral mucositis induced by intensive chemotherapy with hematopoietic stem cell transplantation: Final analysis of a randomized, double- blind, placebo- controlled, phase 2 trial. 2017; doi:10.1371/ journal. pone. 0168854.
11. Barnes DW. Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum- free cell culture. Journal of Cell Biology. 1982; 83: 1-4.
12. Christen RD, Hom DK, Porter DC, Andrews PA, MacLeod CL, Hafstrom L, Howell SB. Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. Journal of Clinical Investigation. 1990; 86: 1632-1640.
13. Gill GN, Lazar CS. Increased phosphotyrosine content and inhibition of proliferation in EGF- treated A431 cells. Nature. 1981; 293: 305-307.
14. Kamata N, Chida K, Rikimaru K, Horikoshi M, Enomoto S, Kuroki T. Growth- inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinoma in culture. Cancer Research. 1986; 46: 1648-1653.
15. Choi J, Moon SY, Hong JP et al. Epidermal growth factor induces cell death in the absence of overexpressed epidermal growth factor receptor and ErbB2 in various human cancer cell lines. Cancer Invest. 2010; 28: 505-514.
16. Ryu SH, Kang KM, Moon SY, Chai GY, Hong JP, Cho KO et al. Therapeutic effects of recombinant human epidermal growth factor (rh EGF) in a murine model of concurrent chemo and radiotherapy- induced oral mucositis. J Radiat Res. 2010; 51: 595-601.
17. Logan RM, Al- Azri AR, Bossi P et al. Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer. 2020; 28: 2485-2498.
18. Rovirosa A, Ferre J, Biete A. Granulocyte macrophage colony stimulating factor mouthwashes heal oral ulcers during head and neck radiotherapy. Int J Radiation Oncology Biol Phys. 1998; 41(4): 747-754.
19. Karthaus M, Rosenthal C, Huebner G et al. Effect of topical oral G-CSF on oral mucositis: a randomized placebo controlled trial. Bone Marrow Transplantation. 1998; 22: 781-785.
20. Gabrilove JL, Jakubowski A, Scher H et al. Effect of granulocyte colony stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional cell carcinoma of the urothelium. N Engl J Med. 1988; 318: 1414-1422.
21. Fleetwood AJ, Cook AD, Hamilton JA. Functions of granulocyte macrophage colony- stimulating factor. Crit Rev Immunol. 2005; 25: 405-428.
22. Hamilton JA. GM- CSF in inflammation and auroimmunity. Trends Immunol. 2002; 23: 403-408.
23. Gutschalk CM, Herold- Mende CC, Fusenig NE, Mueller MM. Granulocyte colony- stimulating factor and granulocyte- macrophage colony stimulating factor promote malignant growth of cells from head and neck squamous cell carcinoma in vivo. Cancer Res. 2006; 66(16): 8026-8035.
24. Chi KH, Chen CH, Chan WK et al. Effect of granulocyte- macrophage colony- stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. Journal of Clinical Oncology. 1995; 13(10): 2620-2628.
25. Zaghloul MS, Dorie MJ, Kallman RF. Interleukin 1 increase thymidine labeling index of normal tissue of mice but not the tumor. Int J Radiat Oncol Biol Phys. 1994; 29: 805-811.
26. Neumanaitis J, Rosenfeld CS, Ash R et al. Phase III randomized double- blind, placebo- controlled trial of rhGM-CSF following allogenic bone marrow transplantation. Bone Marrow Transplant. 1995; 15: 949-954.
27. Masucci G, Fernberg JO, Hoglun Ersin L, Lewensohn R, Strader H. Beneficial treatment of radiotherapy induced mucositis with rh-GM-CSF in patients with tumors of the oral cavity/ oropharynx. Sixth International Congress on Anticancer Treatment. 1996; 167: 83.
28. Throuvalas N, Antonadou D, Pullizi M, Sarris G. Evaluation of efficacy and safety of GM- CSF in the prophylaxis of mucositis in patients with head and neck cancer treated with RT. Eur J Cancer. 1997;41A:431.
29. Crawford J, Ozer H, Stoller R et al. Reduction by granulocyte colony stimulating factor of fever and neutropenia induced by chemotherapy in patients with small cell lung cancer. N Engl J Med. 1991; 325: 164-170.
30. Crawford J, Glaspy J, Vincent M et al. Effect of Filgrastim (r-metHuG- CSF) on oral mucositis in patients with small cell lung cancer receiving chemotherapy cyclophosphamide, doxorubicin and etoposide. Proc Am Soc Clin Oncol. 1994; 13: 331.
31. Gordon B, Spadinger A, Hodges E et al. Effect of granulocyte macrophage colony stimulating factor on oral mucositis after hematopoietic stem-cell transplantation. J Clin Oncol. 1994; 12: 1917-1922.
32. Kannan V, Bapsy PP, Anantha N, Doval DC et al. Efficacy and safety of granulocyte macrophage colony stimulating factor (GM-CSF) on the frequency and severity of radiation mucositis in patients with head and neck carcinoma. Int J Radiat Oncol Biol Phys. 1997; 37: 1005-1010.
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