Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis
Main Article Content
Abstract
Cluster headache is a primary headache disorder and is the most prevalent of the trigeminal autonomic cephalalgias. Cluster headache significantly impacts those affected, necessitating early diagnosis and management. Despite unique clinical features, such as patients experiencing attacks in a circannual pattern and often with a circadian rhythm within bouts, cluster headache patients often are misdiagnosed, mismanaged and have a delay in diagnosis. Preclinical, neuroimaging and clinical studies have advanced our understanding of cluster headache pathophysiology. The trigeminovascular system, the trigeminal autonomic reflex, and the hypothalamus are all involved in the pathophysiology of cluster headache. As our understanding of the pathophysiology of cluster headaches has evolved, new therapeutic options, such as calcitonin gene-related peptide monoclonal antibodies, non-invasive vagal nerve stimulation and sphenopalatine ganglion stimulation, have proved to have efficacy in the treatment of cluster headache. Herein, we aim to review developments to aid readers in their understanding of this debilitating disorder.
Keywords:
Cluster headache, pathophysiology, diagnosis, clinical, calcitonin-gene related peptide
Article Details
How to Cite
GOSALIA, Helin; WEI, Diana Y.; GOADSBY, Peter J..
Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis.
Medical Research Archives, [S.l.], v. 10, n. 12, dec. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3363>. Date accessed: 03 dec. 2024.
doi: https://doi.org/10.18103/mra.v10i12.3363.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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5. Hoffmann J, May A. Diagnosis, pathophysiology, and management of cluster headache. Lancet Neurol. 2018;17(1):75-83. Doi: 10.1016/S1474-4422(17)30405-2.
6. Louter MA, Wilbrink LA, Haan J, et al. Cluster headache and depression. Neurology. 2016;87(18):1899-1906. Doi: 10.1212/WNL.0000000000003282.
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8. Jorge RE, Leston JE, Arndt S, Robinson RG. Cluster headaches: association with anxiety disorders and memory deficits. Neurology. 1999;53(3):543-547. Doi: 10.1212/wnl.53.3.543.
9. Petersen AS, Lund N, Snoer A, Jensen RH, Barloese M. The economic and personal burden of cluster headache: a controlled cross-sectional study. J Headache Pain. 2022;23(1):58. Doi: 10.1186/s10194-022-01427-7.
10. Koehler PJ. Prevalence of headache in Tulp's Observationes Medicae (1641) with a description of cluster headache. Cephalalgia. 1993;13(5):318-320. Doi: 10.1046/j.1468-2982.1993.1305318.x.
11. Isler H. Episodic cluster headache from a textbook of 1745: van Swieten's classic description. Cephalalgia. 1993;13(3):172-174; discussion 149. Doi: 10.1046/j.1468-2982.1993.1303172.x.
12. Harris W. Neuritis and neuralgia. The Lancet. 1926;207(5356):885. Doi: 10.1016/S0140-6736(00)45254-2.
13. Boes CJ, Capobianco DJ, Matharu MS, Goadsby PJ. Wilfred Harris' early description of cluster headache. Cephalalgia. 2002;22(4):320-326. Doi: 10.1046/j.1468-2982.2002.00360.x.
14. Horton BT, MacLean AR, Craig WM. A new syndrome of vascular headache; results of treatment with histamine; a preliminary report. Mayo Clinic Proceedings. 1939;14:250-257.
15. Kunkle EC, Pfeiffer JB, Jr., Wilhoit WM, Hamrick LW, Jr. Recurrent brief headache in cluster pattern. Trans Am Neurol Assoc. 1952;56(77th Meeting):240-243.
16. Bahra A, Goadsby PJ. Diagnostic delays and mis-management in cluster headache. Acta Neurol Scand. 2004;109(3):175-179. Doi: 10.1046/j.1600-0404.2003.00237.x.
17. Frederiksen HH, Lund NL, Barloese MC, Petersen AS, Jensen RH. Diagnostic delay of cluster headache: A cohort study from the Danish Cluster Headache Survey. Cephalalgia. 2020;40(1):49-56. Doi: 10.1177/0333102419863030.
18. Fischera M, Marziniak M, Gralow I, Evers S. The Incidence and Prevalence of Cluster Headache: A Meta-Analysis of Population-Based Studies. Cephalalgia. 2008;28(6):614-618. Doi: 10.1111/j.1468-2982.2008.01592.x.
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