Cardiovascular Autonomic Dysfunction and its association with Aortic Stenosis
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Abstract
Aortic stenosis (AS) remains the most common valvular abnormality that requires intervention and is becoming more prevalent with an ageing population. Untreated symptomatic severe aortic stenosis is associated with a mortality of 50-60% within two years. Valve replacement either surgical or transcatheter remains the only effective treatment.
The autonomic nervous system involuntarily controls many basic cardiac, respiratory, GI and GU functions and plays a central role in the regulation of heart rate and blood pressure. Most recently cardiovascular autonomic dysfunction has shown to be a marker of increased mortality. Severe aortic stenosis is associated with dysregulation of cardiovascular autonomic system. We review this association and discuss how this may facilitate risk assessment and evaluation of treatment response.
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