Main Article Content
The development of novel regenerative material to reduce inflammation and enhance healing process is one of the greatest task in clinical research. PRF ( platelet rich fibrin) is an second generation platelet concentrate which has gained popularity in recent years due to its unique regenerative process. Platelet Rich Fibrin is completely autologous material with extended growth factor release compared to other growth concentrates. The standard quality and quantity of the fibrin matrix , leukocytes, platelets, and growth factors of PRF demands a standard protocol for preparation. The use of Platelet Rich Fibrin treatment has shown increased cellular proliferation, osteogenesis and mineralisation thereby enhancing wound healing capacity. Due to its versatility Platelet Rich Fibrin serves as workhorse in wound healing. This Review article attempts to encapsulate the technique, it’s preparation and use of Platelet Rich Fibrin in the field of oral and maxillofacial surgery.
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
2. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet‑rich fibrin (PRF): A second‑generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37‑44.
3. Kiran NK, Mukunda KS, Tilak Raj TN. Plate let concentrates: A promising innovation in dentistry. J Dent Sci Res 2011;2:50‑61.
4. Whitman DH, Berry RL, Green DM. Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 1997;55:129-9.
5. Madi M, Samuel M, Kedr M. Platelet rich fibrin and periodontal tissue regeneration. Adv Dent Oral Health 2017;4:555649.
6. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet‑rich plasma (P‑PRP) to leucocyte‑ and platelet‑rich fibrin (L‑PRF). Trends Biotechnol 2009;27:158‑67.
7. Prakash S, Thakur A. Platelet concentrates: Past, present and future. J Maxillofac Oral Surg 2011;10:45‑9.
8. Khiste SV, Tari RN. Platelet‑rich fibrin as a biofuel for tissue regeneration. ISRN Biomater 2013;(2013):6.
9. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet‑rich fibrin (PRF): A second‑generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e51‑5.
10. Yu‑Chao C, Kuo‑Chin W, Jiing‑Huei Z. Clinical application of platelet‑rich fibrin as the sole grafting material in periodontal intrabony defects. J Dent Sci 2011;6:181‑8.
11. Chang YC, Zhao JH. Effects of platelet‑rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J 2011;56:365‑71.
12. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet‑rich plasma (PRP) and platelet‑rich fibrin (PRF) in oral and maxillofacial surgery part2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol 2012;13:1231‑56.
13. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 1980;38:613‑6.
14. Tatum OH Jr., Lebowitz MS, Tatum CA, Borgner RA. Sinus augmentation. Rationale, development, long‑term results. N Y State Dent J 1993;59:43‑8.
15. Hamdoun R, Ennibi OK, Ismaili Z. PRF in oral surgery: A literature review. J Med Implants Surg 2016;1:110.
16. Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijayalakshmi R, Pameela E, et al. Platelet‑rich‑fibrin: A novel root coverage approach. J Indian Soc Periodontol 2009;13:50‑4.
17. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet‑rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6‑month study. J Periodontol 2009;80:244‑52.
18. Karunakar P, Prasanna JS, Jayadev M, Shravani GS. Platelet‑rich fibrin, “a faster healing aid” in the treatment of combined lesions: A report of two cases. J Indian Soc Periodontol 2014;18:651‑5.
19. El‑Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, et al. Platelet‑rich plasma: Growth factors and pro‑ and anti‑inflammatory properties. J Periodontol 2007;78:661‑9.
20. Borie E, Oliví DG, Orsi IA, Garlet K, Weber B, Beltrán V, et al. Platelet‑rich fibrin application in dentistry: A literature review. Int J Clin Exp Med 2015;8:7922‑9.