A Prolongation of Peak Time but an Elevated Peak Height of a Clot Wave Form Analysis in Severe Coronavirus Disease 2019

Main Article Content

Kei Suzuki Hideo Wada Kaoru Ikejiri Asami Ito Takeshi Matsumoto Shine Tone Masahiro Hasegawa Motomu Shimaoka Toshiaki Iba Hiroshi Imai

Abstract

Objective: As coronavirus disease 2019 (COVID-19) is frequently associated with thrombotic diseases, the hemostatic abnormalities in cases of COVID-19 have attracted attention. This study examined the hemostatic abnormalities in patients with severe COVID-19.


Methods: Hemostatic abnormalities were examined based on the activated partial thromboplastin time (APTT) and small amount of tissue factor-induced FIX activation (sTF/FIXa) using a clot waveform analysis (CWA). The anti-Xa activity, C5b-9 and ADAMTS 13 values were also examined in these patients.


Results: CWA-APTT and CWA-sTF/FIXa showed that the peak times were prolonged, but peak heights were increased before anticoagulant therapy. The parameters of the CWA-APTT and CWA-sTF/FIXa were not correlated with the anti-Xa activity. The peak times of the CWA-sTF/FIXa were significantly longer in non-survivors than survivors. Although the plasma levels of C5b-9 and ADAMTS13 activity were markedly decreased in severe COVID-19 patients, there were no significant differences in C5b-9 levels or ADAMTS-13 activity between survivors and non-survivors.


Conclusions: The CWA showed the marked hemostatic abnormalities and hypercoagulability in COVID-19 patients, and anticoagulant therapy might not be monitored by routine APTT.

Article Details

How to Cite
SUZUKI, Kei et al. A Prolongation of Peak Time but an Elevated Peak Height of a Clot Wave Form Analysis in Severe Coronavirus Disease 2019. Medical Research Archives, [S.l.], v. 11, n. 1, jan. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3549>. Date accessed: 23 may 2024. doi: https://doi.org/10.18103/mra.v11i1.3549.
Section
Research Articles

References

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