Lead Drug Discover Strategies from Natural Medicines Based on Network Pharmacology

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Published Feb 28, 2023
DOI: https://doi.org/10.18103/mra.v11i2.3559

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Main Article Content

Shitang Ma
College of biological and pharmaceutical engineering, West Anhui University, Lu’an, China.
Jiafu Hou
Mudanjiang Medical University, Mudanjiang, China.
Shijuan Liu
Mudanjiang Medical University, Mudanjiang, China.
Fucheng Zhu
College of biological and pharmaceutical engineering, West Anhui University, Lu’an, China.
Peipei Wei
College of biological and pharmaceutical engineering, West Anhui University, Lu’an, China.
Chengtao Feng
Anhui University of Chinese Medicine, Hefei, China.
Naidong Chen
College of biological and pharmaceutical engineering, West Anhui University, Lu’an, China.

Abstract

The need for therapeutics to overcome development of existing diseases research to discover new lead agents. In the face of public health challenges worldwide, natural medicines play a pivotal role in innovative lead drug discovery. Network pharmacology can easily construct complicated poly-pharmacology network based on lead compound, biological function, and bioactive target proteins, which meets the overall feature of natural medicines, and enable to elucidate the action mechanism at molecule-protein level with systematic view. In this work, we first summarized the recent progress delineating lead drug development and its interaction with natural medicines. Second, we focused on the relationship between natural medicines and network pharmacology. Additionally, we discussed current issues and potential prospects for the lead drug discover from natural medicines by network pharmacology. Further investigations should be focus on relevant structural analysis for biological experiment, also the dynamic and quantitative network development. In summary, it is a rational approach for innovative lead drug discovery, and with the development of structure and biology research, this approach makes it a very powerful method for the lead molecules in a high-throughput manner from a comprehensive and powerful special multi-compound to target protein/disease poly pharmacology network.

Keywords: lead drug discover, natural medicines, network pharmacology, screen, poly-pharmacology, multi-target

Article Details

How to Cite
MA, Shitang et al. Lead Drug Discover Strategies from Natural Medicines Based on Network Pharmacology. Medical Research Archives, [S.l.], v. 11, n. 2, feb. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3559>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.18103/mra.v11i2.3559.
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Issue
Vol 11 No 2 (2023): February Issue, Vol.11 Issue 2
Section
Research Articles

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