Glycemic Index of a High Protein and High Fiber Oral Nutritional Supplement Vidaslim®
Main Article Content
Abstract
Background: Food products with a low Glycemic index (GI) help control blood glucose levels and may also help reduce body weight. The risk of obesity-related chronic diseases increases with the consumption of refined carbohydrate-rich or a diet with high GI food choices. Vidaslim®, an Oral Nutrition Supplement was formulated by Signutra Inc, with a high protein blend (whey, soy, and casein), dietary Fiber (polydextrose), and several phytonutrients with an attempt to reduce body weight.
Aim: To determine the GI of the Vidaslim® in fifteen overweight / obese people aged between 20 and 45 years.
Methodology: The study participants consumed the test food, Vidaslim® containing 25 g of available carbohydrate. Participants underwent 3 days of reference food (glucose) testing and 1 day of test food with 2 days of wash-out period. In between capillary blood glucose was measured after overnight fasting at 0, 15, 30, 45, 60, 90, and 120 min after consuming the reference and test food in a random order. The GI was assessed using a validated protocol by FAO and ISO (2010). Following this, the glycemic load (GL) of Vidaslim® was also calculated.
Results: Out of 15 participants who completed the study, 3 were removed as statistical outliers (GI > mean ± 2SD), and hence the data was presented for the remaining 12 participants. The mean age of the participants was 28.1±5.4 years, and body mass index (BMI) was 27.2±2.7 kg/m2. Vidaslim® had a low GI value of 21±3.6 (Mean+SD). The GI value was not influenced by age, sex, dietary total calories, protein, fat, carbohydrates, dietary Fiber, and physical activity levels. The Glycemic Load (GL) of Vidaslim® was 4.86 (low GL).
Conclusion: The oral nutritional supplement, Vidaslim®, has a low GI and GL value, and hence, could be a suitable healthy supplement for those with obesity and diabetes.
Keywords:
glycemic index, nutritional supplement, weight loss, obesity, diabetes
Article Details
How to Cite
GAYATHRI, Rajagopal et al.
Glycemic Index of a High Protein and High Fiber Oral Nutritional Supplement Vidaslim®.
Medical Research Archives, [S.l.], v. 11, n. 3, apr. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3576>. Date accessed: 04 dec. 2024.
doi: https://doi.org/10.18103/mra.v11i3.3576.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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7. Galaviz KI, Narayan KMV, Lobelo F, Weber MB. Lifestyle and the Prevention of Type 2 Diabetes: A Status Report. Am J Lifestyle Med. 2018;12(1):4-20. doi:10.1177/1559827615619159
8. Mohan V, Unnikrishnan R, Shobana S, Malavika M, Anjana RM, Sudha V. Are excess carbohydrates the main link to diabetes & its complications in Asians? Indian J Med Res. 2018;148(5):531-538. doi:10.4103/ijmr.IJMR_1698_18
9. Jenkins DJA, Dehghan M, Mente A, et al. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality. N Engl J Med. 2021;384(14):1312-1322. doi:10.1056/NEJMoa2007123
10. Thomas D, Elliott EJ. Low Glycemic index, or low Glycemic load, diets for diabetes mellitus. Cochrane Database Syst Rev. 2009;2009(1):CD006296. doi:10.1002/14651858.CD006296.pub2
11. Zafar MI, Mills KE, Zheng J, et al. Low-glycemic index diets as an intervention for diabetes: a systematic review and meta-analysis. Am J Clin Nutr. 2019;110(4):891-902. doi:10.1093/ajcn/nqz149
12. Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low–Glycemic Index Diets in the Management of Diabetes: A meta-analysis of randomized controlled trials. Diabetes Care. 2003;26(8):2261-2267. doi:10.2337/diacare.26.8.2261
13. Misra A, Sharma R, Gulati S, et al. Consensus dietary guidelines for healthy living and prevention of obesity, the metabolic syndrome, diabetes, and related disorders in Asian Indians. Diabetes Technol Ther. 2011;13(6):683-694. doi:10.1089/dia.2010.0198
14. Radulian G, Rusu E, Dragomir A, Posea M. Metabolic effects of low Glycemic index diets. Nutrition Journal. 2009;8(1):5. doi:10.1186/1475-2891-8-5
15. Radulian G, Rusu E, Dragomir A, Posea M. Metabolic effects of low Glycemic index diets. Nutrition Journal. 2009;8:5. doi:10.1186/1475-2891-8-5
16. Bene J, Hadzsiev K, Melegh B. Role of carnitine and its derivatives in the development and management of type 2 diabetes. Nutr & Diabetes. 2018;8(1):1-10. doi:10.1038/s41387-018-0017-1
17. Carmo MMR do, Walker JCL, Novello D, et al. Polydextrose: Physiological Function, and Effects on Health. Nutrients. 2016;8(9). doi:10.3390/nu8090553
18. Ma J, Stevens JE, Cukier K, et al. Effects of a Protein Preload on Gastric Emptying, Glycemia, and Gut Hormones After a Carbohydrate Meal in Diet-Controlled Type 2 Diabetes. Diabetes Care. 2009;32(9):1600. doi:10.2337/dc09-0723
19. Park JH, Bae JH, Im SS, Song DK. Green tea and type 2 diabetes. Integrative Medicine Research. 2014;3(1):4. doi:10.1016/j.imr.2013.12.002
20. Pintaudi B, Di Vieste G, Bonomo M. The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. Int J Endocrinol. 2016;2016:9132052. doi:10.1155/2016/9132052
21. Veena N, Surendranath B, Arora S. Polydextrose as a Functional Ingredient and its Food Applications: A Review. IJDS. 2016;69(3):239-251. doi:10.5146/IJDS.V69I3.51101.G24364
22. Watson LE, Phillips LK, Wu T, et al. Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clin Nutr. 2019;38(6):2827-2832. doi:10.1016/j.clnu.2018.12.014
23. Wu T, Little TJ, Bound MJ, et al. A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes. Diabetes Care. 2016;39(4):511-517. doi:10.2337/dc15-2298
24. Xu R, Bai Y, Yang K, Chen G. Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials. Nutrition & Metabolism. 2020;17(1):56. doi:10.1186/s12986-020-00469-5
25. Brouns F, Bjorck I, Frayn KN, et al. Glycemic index methodology. Nutr Res Rev. 2005;18(1):145-171. doi:10.1079/NRR2005100
26. International Standards Organization. ISO 26642-2010 Food Products Determination of the Glycemic Index (GI) and Recommendation for Food Classification. International Standards Organization; 2010. Accessed March 16, 2022. https://www.iso.org/cms/render/live/en/sites/isoorg/contents/data/standard/04/36/43633.html
27. FAO/WHO. Carbohydrates in human nutrition. Report of a Joint FAO/WHO Expert Consultation. FAO Food Nutr Pap. 1998;66:1-140.
28. Mohan V, Radhika G, Sathya RM, Tamil SR, Ganesan A, Sudha V. Dietary carbohydrates, Glycemic load, food groups and newly detected type 2 diabetes among urban Asian Indian population in Chennai, India (Chennai Urban Rural Epidemiology Study 59). Br J Nutr. 2009;102(10):1498-1506. doi:10.1017/S0007114509990468
29. Ceriello A, Colagiuri S. International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations. Diabet Med. 2008;25(10):1151-1156. doi:10.1111/j.1464-5491.2008.02565.x
30. International Diabetes Federation. IDF Diabetes Atlas. Seventh edition. International Diabetes Federation; 2015. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjimuLmzaL7AhWCSWwGHW1NBcgQFnoECAkQAQ&url=https%3A%2F%2Fwww.idf.org%2Fcomponent%2Fattachments%2Fattachments.html%3Fid%3D728%26task%3Ddownload&usg=AOvVaw0iHD15k39yaQoal5zPvBt0
31. Bhupathiraju SN, Tobias DK, Malik VS, et al. Glycemic index, glycemic load, and risk of type 2 diabetes: results from 3 large US cohorts and an updated meta-analysis. Am J Clin Nutr. 2014;100(1):218-232. doi:10.3945/ajcn.113.079533
32. Wolever TMS, Gibbs AL, Chiasson JL, et al. Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD). Nutr Metab Cardiovasc Dis. 2013;23(3):227-234. doi:10.1016/j.numecd.2011.12.011
33. Nisak MB, Ruzita AT, Norimah AK, Azmi KN, Fatimah A. Acute Effect of Low and High Glycemic Index Meals on Post-prandial Glycemia and Insulin Responses with Type 2 Diabetes Mellitus. Malaysian Journal of Medicine and Health Sciences. 2009;5(1):11-20. Accessed March 17, 2022. http://wprim.whocc.org.cn/admin/article/articleDetail?WPRIMID=628073&articleId=628073
34. Vlachos D, Malisova S, Lindberg FA, Karaniki G. Glycemic Index (GI) or Glycemic Load (GL) and Dietary Interventions for Optimizing Postprandial Hyperglycemia in Patients with T2 Diabetes: A Review. Nutrients. 2020;12(6). doi:10.3390/nu12061561
35. Meena PC, Kumar S, Srinivas K, et al. Great Indian Food Paradox: Trends and Patterns. Agri Econ Rese Revi. 2016;29(conf):31. doi:10.5958/0974-0279.2016.00031.8
36. Misra A, Singhal N, Sivakumar B, Bhagat N, Jaiswal A, Khurana L. Nutrition transition in India: Secular trends in dietary intake and their relationship to diet-related non-communicable diseases. Journal of Diabetes. 2011;3(4):278-292. doi:10.1111/j.1753-0407.2011.00139.x
37. Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab. 2001;86(11):5366-5371. doi:10.1210/jcem.86.11.7992
38. Right to Protein, Madan J. Indias-Protein-Paradox-Study.pdf. Accessed November 10, 2022. https://righttoprotein.com/assets/pdf/Indias-Protein-Paradox-Study.pdf
39. Juanola-Falgarona M, Salas-Salvadó J, Ibarrola-Jurado N, et al. Effect of the glycemic index of the diet on weight loss, modulation of satiety, inflammation, and other metabolic risk factors: a randomized controlled trial. Am J Clin Nutr. 2014;100(1):27-35. doi:10.3945/ajcn.113.081216
40. Hofman DL, Buul VJ van, Brouns FJPH. Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins. Critical Reviews in Food Science and Nutrition. 2016;56(12):2091. doi:10.1080/10408398.2014.940415
41. Pesta DH, Samuel VT. A high-protein diet for reducing body fat: mechanisms and possible caveats. Nutrition & Metabolism. 2014;11(1):53. doi:10.1186/1743-7075-11-53
42. Smith K, Davies KAB, Stevenson EJ, West DJ. The Clinical Application of Mealtime Whey Protein for the Treatment of Postprandial Hyperglycaemia for People With Type 2 Diabetes: A Long Whey to Go. Frontiers in Nutrition. 2020;7. doi:10.3389/fnut.2020.587843
43. Wang S, Chen L, Yang H, Gu J, Wang J, Ren F. Regular intake of white kidney beans extract (Phaseolus vulgaris L.) induces weight loss compared to placebo in obese human subjects. Food Science & Nutrition. 2020;8(3):1315. doi:10.1002/fsn3.1299
44. Paddon-Jones D, Westman E, Mattes RD, Wolfe RR, Astrup A, Westerterp-Plantenga M. Protein, weight management, and satiety. Am J Clin Nutr. 2008;87(5):1558S-1561S. doi:10.1093/ajcn/87.5.1558S
45. Hoffman JR, Falvo MJ. Protein - Which is Best? J Sports Sci Med. 2004;3(3):118-130.
46. Davoodi SH, Shahbazi R, Esmaeili S, et al. Health-Related Aspects of Milk Proteins. Iranian Journal of Pharmaceutical Research : IJPR. 2016;15(3):573. Accessed March 16, 2022. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5149046/
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