Back to the Future – A 19th Century Perspective on Cancer
Main Article Content
Abstract
Several lines of evidence suggest that current negative trends in cancer incidence represent a deteriorating exposome. Analysis of its key components may enable focused and specific cancer prevention strategies beyond the scope of current diet and lifestyle recommendations, and may also be helpful for the increasing numbers of patients in remission. An outline chemo-preventive strategy is derived from historical data and developed for modern use.
Keywords:
cancer, survival, anastasis, resistance, prevention, diet, mid-Victorian
Article Details
How to Cite
CHANAN-KHAN, Prof. Asher; CLAYTON, Dr. Paul.
Back to the Future – A 19th Century Perspective on Cancer.
Medical Research Archives, [S.l.], v. 11, n. 9, oct. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3658>. Date accessed: 16 may 2024.
doi: https://doi.org/10.18103/mra.v11i10.3658.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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Caspase refs
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1. https://clinicaltrials.gov/ct2/resources/trends Accessed December 9th 2022
2. Ugai T, Sasamoto N, Lee HY, Ando M, Song M, Tamimi RM, Kawachi I, Campbell PT, Giovannucci EL, Weiderpass E, Rebbeck TR, Ogino S. Is early-onset cancer an emerging global epidemic? Current evidence and future implications. Nat Rev Clin Oncol. 2022 Oct;19(10):656-673.
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4. Cancer Research UK ’21. https://www.cancerresearchuk.org/health-professional/cancer-statistics/risk/lifetime-risk#heading-Zero Accessed December 11th, 2022
5. Karagiannis GS, Pastoriza JM, Wang Y, Harney AS, Entenberg D, Pignatelli J, Sharma VP, Xue EA, Cheng E, D'Alfonso TM, Jones JG, Anampa J, Rohan TE, Sparano JA, Condeelis JS, Oktay MH. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med. 2017 Jul 5;9(397):eaan0026.
6. Hughes R, Qian BZ, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW, Lewis CE. Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. Cancer Res. 2015;75:3479–3491.
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8. Mansoori B, Mohammadi A, Davudian S, Shirjang S, Baradaran B. The Different Mechanisms of Cancer Drug Resistance: A Brief Review. Adv Pharm Bull. 2017 Sep;7(3):339-348.
9. Mirzayans R., Murray D. Intratumor heterogeneity and therapy resistance: Contributions of dormancy, apoptosis reversal (anastasis) and cell fusion to disease recurrence. Int. J. Mol. Sci. 2020;21:1308.
10. Herbein G, Nehme Z. Polyploid giant cancer cells, a hallmark of oncoviruses and a new therapeutic challenge. Front. Oncol. 2020;10:567116.
11. Mirzayans R, Murray D. What Are the Reasons for Continuing Failures in Cancer Therapy? Are Misleading/Inappropriate Preclinical Assays to Be Blamed? Might Some Modern Therapies Cause More Harm than Benefit? Int J Mol Sci. 2022 Oct 30;23(21):13217.
12. Zaitceva V, Kopeina GS, Zhivotovsky B. Anastasis: Return journey from cell death. Cancers. 2021;13:3671.
13. Tang HM, Tang HL. Anastasis: Recovery from the brink of cell death. R. Soc. Open Sci. 2018;5:180442.
14. Mohammed RN, Khosravi M, Rahman HS, Adili A, Kamali N, Soloshenkov PP, Thangavelu L, Saeedi H, Shomali N, Tamjidifar R, Isazadeh A, Aslaminabad R, Akbari M. Anastasis: cell recovery mechanisms and potential role in cancer. Cell Commun Signal. 2022 Jun 3;20(1):81.
15. Seervi M, Sumi S, Chandrasekharan A, Sharma AK, Santhosh Kumar TR. Molecular profiling of anastatic cancer cells: Potential role of the nuclear export pathway. Cell Oncol. 2019;42:645–661.
16. Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY. Apoptotic cells activate the ‘‘phoenix rising’’ pathway to promote wound healing and tissue regeneration. Sci. Signal. 2010;3:ra13.
17. Ng W-L, Huang Q, Liu X, Zimmerman M, Li F, Li C-Y. Molecular mechanisms involved in tumor repopulation after radiotherapy. Transl. Cancer Res. 2013;2:442–448.
18. Cheng J, Tian L, Ma J, Gong Y, Zhang Z, Chen Z, Xu B, Xiong H, Li C, Huang Q. Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma. Mol. Oncol. 2015;9:105–114.
19. Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O’Sullivan B, He Z, Peng Y, Tan AC and 10 others. Caspase3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat. Med. 2011;17:860–866.
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22. Liu C, Li CY, Yuan F. Mathematical modeling of the Phoenix Rising pathway. PLoS Comput Biol. 2014 Feb 6;10(2):e1003461.
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24. Wender PA, Gentry ZO, Fanelli DJ, Luu-Ngoyen QH, McAteer OD, Njoo E. Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues. Nat. Chem. (2022). https://doi.org/10.1038/s41557-022-01048-2
25. Panizza BJ, de Souza P, Cooper A, Roohullah A, Karapetis CS, Lickliter JD. Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an intratumoral injection of tigilanol tiglate (EBC-46). EBioMedicine. 2019 Dec;50:433-441.
26. Marron TU, Schwartz M, Corbett V, Merad M. Neoadjuvant Immunotherapy for Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2022 Jun 30;9:571-581.
27. Svensson-Arvelund J, Cuadrado-Castano S, Pantsulaia G, Kim K, Aleynick M, Hammerich L, Upadhyay R, Yellin M, Marsh H, Oreper D, Jhunjhunwala S, Moussion C, Merad M, Brown BD, García-Sastre A, Brody JD. Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity. Nat Commun. 2022 Nov 22;13(1):7149.
28. Clayton P, Rowbotham J. How the mid-Victorians worked, ate and died. Int J Environ Res Public Health. 2009 Mar;6(3):1235-53.
29. Gurven M, Kaplan H, Zelada Supa A. 2007. Mortality experience of Tsimanen Amerindians of Bolivia: regional variation and temporal trends. Am J Hum Biol 19: 376-398.
30. Stieglitz J, Blackwell AD, Gutierrez, RQ, Linares, EC, Gurven M, Kaplan H. (2012). Modernization, sexual risk-taking, and gynecological morbidity among Bolivian forager-horticulturalists. PLoS ONE, 7, e50384.
31. Charlton J, Murphy M, editors. The Health of Adult Britain 1841–1994. 2 volumes. London: National Statistics; 2004.
32. Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Allès B, Méjean C, Deschasaux M, Fassier P, Latino-Martel P, Beslay M, Hercberg S, Lavalette C, Monteiro CA, Julia C, Touvier M. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ. 2018 Feb 14;360:k322.
33. Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Méjean C, Andrianasolo RM, Chazelas E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ. 2019 May 29;365:l1451.
34. Chang K, Gunter MJ, Rauber F, Levy RB, Huybrechts I, Kliemann N, Millett C, Vamos EP. Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank. eClinical Med. Published: January 31, 2023DOI:https://doi.org/10.1016/j.eclinm.2023.101840
35. Ling S, Zaccardi F, Issa E, Davies MJ, Khunti K, Brown K. Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England. Diabetologia. 2023 Jan 24. doi: 10.1007/s00125-022-05854-8.
36. Osler W: The Principles and Practice of Medicine. New York, D. Appleton and Company,1892
37. LeBlanc BW, Albina JE, Reichner JS. The effect of PGG-beta-glucan on neutrophil chemotaxis in vivo. J Leukoc Biol. 2006 Apr;79(4):667-75.
38. Lee YJ, Paik DJ, Kwon DY, Yang HJ, Park Y. Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults: a randomized, double-blind, placebo-controlled, parallel-group study. Nutr Res Pract. 2017 Feb;11(1):43-50.
39. Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol. 2004 Jul 15;173(2):797-806.
40. Kirmaz C, Bayrak P, Yilmaz O, Yuksel H. Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur Cytokine Netw. 2005 Jun;16(2):128-34.
41. Kang HJ, Youn YK, Hong MK, Kim LS. Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. J Korean Med Sci. 2011 Jul;26(7):893-9.
42. Barth TJ, Zöller J, Kübler A, Born IA, Osswald H. Redifferentiation of oral dysplastic mucosa by the application of the antioxidants beta-carotene, alpha-tocopherol and vitamin C. Int J Vitam Nutr Res. 1997;67(5):368-76.
43. Marzocco S, Singla RK, Capasso A. Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer. Molecules. 2021 Sep 2;26(17):5333.
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