Inhibition of Cytochrome P450 by Carbon Monoxide: Relevance to Drug Resistance in Human Breast Cancer Therapy
Main Article Content
Abstract
Drug resistance to conventional chemotherapeutics is a great impediment to cancer therapy. A major part of this problem arises from rapid metabolism of the drugs by cytochrome P450 class of enzymes before they reach their targets or at the target itself. Inhibition of such enzymatic deactivation of the drugs could offer partial rescue and make chemotherapy more effective. Site specific delivery of exogenous carbon monoxide has been shown to inhibit cytochrome P450 enzymes and resurrect sensitivity to chemotherapeutics already available in the market. Successful design for application of such CO delivery will thus be extremely desirable to patients particularly in poor countries where the antibody-based or nanodrug therapies, discovered recently, are too expensive for the general population. The potential of such carbon monoxide-induced cytochrome P450 inhibition to improve drug sensitization to conventional chemotherapeutics in breast cancer therapy has been discussed in this account.
Article Details
How to Cite
KAWAHARA, Brian; MASCHARAK, Pradip K..
Inhibition of Cytochrome P450 by Carbon Monoxide: Relevance to Drug Resistance in Human Breast Cancer Therapy.
Medical Research Archives, [S.l.], v. 11, n. 4, apr. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3732>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.18103/mra.v11i4.3732.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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10. Ryter SW, Alam J, Choi AMK. Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Phys Rev. 2006;86(2):583-650.
11. Ryter SW, Choi AMK. Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models. Novartis Foundation Symposium 280. Ch. 12 Chadwick DJ, Goode J, Eds; 2008. DOI:10.1002/9780470059593.ch12.
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13. Tripathi R, Yang X, Ryter SW, Wang B. Carbon monoxide as a therapeutic for airway diseases: Contrast and comparison of various CO delivery modalities. Curr Top Med Chem. 2021; 21(32): 2890–2908.
14. Bathoorn E, Slebos D-J, Postma DS, et al. Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. Eur Respir J. 2007;30:1131-1137.
15. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–867.
16. Munn L. Cancer and inflammation. Wiley Interdiscip Rev Syst Biol Med. 2017;9(2):10.1002/wsbm.1370.
17. Wegiel B, Gallo D, Csizmadia E, et al. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res. 2013;73(23):7709-21.
18. Ahmed S, Hewett PW, Fujisawa T, et al. Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost 2015;113(2):329-37.
19. Vo TTT, Vo QC, Tuan VP, Wee Y, Cheng H-C, Lee I-T. The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine. Rodox Biol. 2021;46-102124. DOI: 10.1016/j.redox.2021.102124.
20. Kawahara B, Moller T, Hu-Moore K, Carrington S., Faull KF, Sen S, Mascharak PK. Attenuation of antioxidant capacity in human breast cancer cells by carbon monoxide through inhibition of cystathionine b-synthase activity: Implications in chemotherapeutic drug sensitivity. J Med Chem. 2017;60:8000-8010.
21. Kawahara B, Sen S, Mascharak PK. Reaction of carbon monoxide with cystathionine b-synthase: Implications on drug efficacies in cancer chemotherapy. Future Med Chem. 2020;12(4):325-337.
22. Goebel U, Wollborn J. Carbon monoxide in intensive care medicine – time to start the therapeutic application?! Intens Care Med Expt. 2020;8(1):2. DOI: 10.1186/s40635-020-0292-8.
23. Vitek L, Gbelcova H, Muchova L, Fujisawa T, Ahmed A, Rumi T. Antiproliferative effects of carbon monoxide on pancreatic cancer. Oncology. 2014;46:369-375.
24. Lv C, Su Q, Fang J, Yin H. Styrene-maleic acid copolymer-encapsulated carbon monoxide releasing molecule-2 (SMA/CORM-2) suppresses proliferation, migration and invasion of colorectal cancer cells in vitro and in vivo. Biochem Biophys Res Comm. 2019;520:320-326.
25. Yin H, Fang J, Liao L, Maeda H, Su Q. Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. BMC Cancer. 2014;14:436. DOI: 10.1186/1471-2407-14-436.
26. Lian S, Xia Y, Ung TT, et al. Carbon monoxide releasing molecule-2 ameliorates IL-1β-induced IL-8 in human gastric cancer cells. Toxicology. 2016;15:361-362:24-38.
27. Wu ML, Ho YC, Lin, CY, Yet SF. Heme oxygenase-1 in inflammation and cardiovascular disease. Am J Cardiovasc Dis. 2011;1:150–158.
28. Raval CM, Chintan, J, Lee P. Heme oxygenase-1 in lung disease. Curr Drug Targets. 2010;11:1532–1540.
29. Was H, Dulak J, Jozkowicz A. Heme oxygenase-1 in tumor biology and therapy. Curr Drug Targets. 2010;11:1551–1570.
30. Kinobe RT, Dercho RA, Nakatsu K. Inhibitors of the heme oxygenase—carbon monoxide system: on the doorstep of the clinic? Can. J. Physiol Pharmaco. 2008;86:577-599.
31. Ryter SW, Choi AM. Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine. Curr Drug Targets. 2010;11:1485–1494.
32. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010;9:728–743.
33. Fujita T, Toda K, Karimova A, et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 2001;7:598–604.
34. Tulis DA, Keswani AN, Peyton KJ, Wang H, Schafer AI, Durante W. Local administration of carbon monoxide inhibits neointima formation in balloon injured rat carotid arteries. Cell Mol Biol. 2005;51(5): 441–446.
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