Corpus Callosum Hematoma Revealing Imported Neuromalarial Disease: A Case Report

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El Khahouri I Tougar S Maghrabi O Mashrouh W Mabchour M Mabchour M Charra B

Abstract

Cerebral malaria, one of the most serious complications of Plasmodium falciparum infection, is characterized by the sequestration of parasitized red blood cells (HP) within deep cerebral microvessels. Herein, we report the case of a 30-year-old man with no particular medical history, with the notion of stay in an endemic area [Ivory Coast] for 3 months. , who was admitted to our medical intensive care unit for status epilepticus. Upon admission the patient was immediately intubated due to persistent seizures. He was febrile at 39°C. Lumbar puncture was performed and was sterile.  A cerebral CT showed a slight cerebral edema with exaggerated hyper density of the cerebral tent. A cerebral MRI showed a hypersignal of selenium from the corpus callosum, corresponding to a hematoma of the corpus callosum which subsequently revealed an imported neuroma aria. A thick blood smear was then performed, showing the presence of plasmodium falciparum trophozoites, following which the patient was put on Artesunate. The evolution was favorable,and the patient was extubated without neurological complications .We also point out the challenges this diagnosis may pose, especially in a non-endemic country such as Morocco.

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How to Cite
I, El Khahouri et al. Corpus Callosum Hematoma Revealing Imported Neuromalarial Disease: A Case Report. Medical Research Archives, [S.l.], v. 11, n. 6, june 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3899>. Date accessed: 07 nov. 2024. doi: https://doi.org/10.18103/mra.v11i6.3899.
Section
Case Reports

References

1. World Health Organization. World malaria report 2016. Geneva: http:\www.who.int\malaria\publication\worldmalariareport2016\report\en
2. Warrell, D.A. (1987) “Pathophysiology of severe falciparum malaria in man,” Parasitology, 94(S1). Available at: https://doi.org/10.1017/s0031182000085826.
3. Mohanty, S. et al. (2011) Brain swelling and mannitol therapy in adult cerebral malaria: A randomized trial, OUP Academic. Oxford University Press. Available at: https://academic.oup.com/cid/article/53/4/349/445837 (Accessed: April 27, 2023).
4. Maude, R.J. et al. (2014) “Magnetic resonance imaging of the brain in adults with severe falciparum malaria,” Malaria Journal, 13(1). Available at: https://doi.org/10.1186/1475-2875-13-177.
5. Seydel, K.B. et al. (2015) “Brain swelling and death in children with cerebral malaria,” New England Journal of Medicine, 372(12), pp. 1126–1137. Available at: https://doi.org/10.1056/nejmoa1400116.
6. Laurent V et al. Cerebral malaria during severe imported malaria in adults: clinical features, prognostic indices and brain imaging. Abstr. P 568, ICAAC 2012, San Francisco
7. Greenwood, B., Marsh, K. and Snow, R. (1991) “Why do some African children develop severe malaria?,” Parasitology Today, 7(10), pp. 277–281. Available at: https://doi.org/10.1016/0169-4758(91)90096-7.
8. Grau, G.E. and Lou, J. (1993) “TNF in vascular pathology: The importance of platelet-endothelium interactions,” Research in Immunology, 144(5), pp. 355–363. Available at: https://doi.org/10.1016/s0923-2494(93)80080-i.
9. Looareesuwan, S. et al. (1995) “Magnetic resonance imaging of the brain in patients with cerebral malaria,” Clinical Infectious Diseases, 21(2), pp. 300–309. Available at: https://doi.org/10.1093/clinids/21.2.300.
10. Piguet, P.F. et al. (2000) “Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice,” Infection and Immunity, 68(7), pp. 3822–3829. Available at: https://doi.org/10.1128/iai.68.7.3822-3829.2000.