Sex Dimorphism of Calcium and Magnesium Metabolism
Main Article Content
Abstract
Background. There is a need for assessing personalized nutritional status of the bio elements magnesium (Mg) and calcium (Ca).
Objective. We studied the Mg and Ca nutritional status by analyzing their concentrations frequency distribution in the long-term biological indicator tissue of hair.
Design. Hair Mg and Ca were analyzed in 1073 apparently healthy white adult Caucasians of both sexes [734 women (♀) and 339 men (♂)] with the ICP MS. The concentrate frequency distribution data were log transformed and the nutritional status assessed with the Median Derivatives Bioassay.
Results. The hair median values (µg∙g-1) were Women (♀) Mg 254 and Men (♂) Mg 137.2 whereas W (♀) Ca median was 721.4 and M (♂) Ca 492.0, respectively. Adequate nutritional status range limits arranged themselves along the linear part of the sigmoid saturation curve. These linear adequate window range limits were for women magnesium W (♀) Mg 29.7–270.6 and for men M (♂) Mg 20.5–90.2. The adequate range limits for calcium were W (♀) Ca 487.7–4456.8 and M (♂) Ca 26.1–816.4. The bone seeking bio elements Ca, Mg, and Sr showed the same increasing affinity for women hair deposition, whereas the major cellular electrolytes of sodium and potassium were almost imperceptibly higher in men than women.
Conclusions. Women hair incorporates Mg and Ca at about 2.5 times higher rate than men hair. The hair Median Derivatives Bioassay is a convenient painless way to assess and monitor the personalized dietary nutritional status of Mg and Ca in women and men.
Article Details
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References
2. Momčilović B, Prejac J, Skalny AV, Mimica N. In search of decoding the syntax of the bio elements in human hair - A critical overview. J Trace Element Med Biol 2018;50:543-553
3. Bass DA, Hickog G, Quig D, Urek K. Trace element analysis in hair : factors determining accuracy , precision, and reliability. Alternative Medicine Rev., 2001;6:472-481.
4. Mesko MF, Henn AS, Moraes Flores EM. La Rosa Novo D, Wilhelm EA, Elemental determination for clinical diagnosis: Challenges and trends in sample preparation. Comprehensive Analyt Chem 2022;97:1-51.
5. Miekelay B, Dias Carneiro MTW, Porto de Silveira CL. How reliable human hair reference intervals for trace elements ? Sci Total Environment1998;218:9-17.
6. Dinh K, Wang O. A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β, Biophys J 2022;121:2638-2652.
7. Morović S, Višnjević V, Morović J, Lykken GI, Skalny AV, Končar D, Momčilović B. The hair golden range yardstick for assessing the optimal bio element nutritional status. Open J Food Nutr Sci. 2022;4:25-44.
8. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2013;310(20):2191-4.
9. Oppenheim N. Questionnaire – design, interviewing and attitude measurement. Continuum, London, England, 1992.
10. Momčilović B, Prejac J, Višnjević V, Mi,mica N, Morović S, Ćelebić A, Drmić S, ,Skalny AV. Environmental human silver exposure , Toxicol Environ Chem 2012;94:1238-12146.
11. International Atomic Energy Commission (IAEA). Elemental analysis of biological materials. IAEA-TEC.DOC 1970. Vienna, Austria: International Atomic Energy Agency, 1980.
12. Burges C. Valid analytical methods and procedures. Cambridge, England: The Royal Society of Chemistry, 2000.
13. Finney DJ (Forwarded by Tattersfield F). Probit analysis. A statistical treatment of the sigmoid response curve. 2nd ed. Cambridge, UK: Cambridge University Press, 1952.
13 a. Momčilović B. Dietary salt in the whrill of nutritional sciences, public health, and food processing industry, Trace Elements in Medicine 2021;22:3-13
13b. Prejac J, Višnjević V, Skalny AA, Grabeklis AR, Mimica N, Momčiloviš B. Hair for a long term biological indicator tissue for accessing the strontium nutritional status of men and women, J Trace Elements in Med Biol 2017;42:11-17.
14. Weaver CM, Peacock M. Calcium, Adv Nutr 2019;10:546-548.4.
15. Costello R, Wallace TCV, Rosanoff A. Magnesium, Adv Nutr 2016;7:199-201.
16. Momčilović B. Novel visualization of the Periodic System of Elements. The orthogonal dimension, Trace Elements in Medicine, 2007;8:1-6.
17. Compton J. Osteoporosis, in Oxford Textbook of Medicine, 4th ed, Part 3, Chapter19.1, 2003;186-189.
18. Unwind RJ, Robertson WG, Capadsso G. Urinary stones, nephrocalcinosis, and renal tubular acidosis, in Oxford Textbook of Medicine, 4th ed, Part 3, Chapter 20.13, 2003;4334=446.
19. Selye H. Calciphylaxis, Chicago Univ Press, Chicago, IL. 1962.
20. Momčilović B, Lykken GI, Traudt J, Ward T. Artificial intelligence advances our knowledge of human memory, North Dakota Academy of Sciences Meeting, Minot, ND, 2023