Impact of Obstetric Nutritional Risk on Perinatal Morbidity: A Case-Control Study

Main Article Content

Roberto Anaya-Prado Maria del C. Soberanis-Cebrero Alan Soto-Murakami Sthefano Ventura-Hernández Michelle M. Anaya-Fernández Roberto Anaya-Fernández Consuelo C. Azcona-Ramírez Anna E. García-Berenfeld Ximena I. Del Rio-Murillo Andrés J. Bolaños-Chang Reynardi L. Sutanto Daniela Reyes-Gonzalez Ana P. Cardenas-Fregoso Bryanna I.L. Saputro Ana M. Reyes-Perez

Abstract

Objective. Malnutrition is among the most relevant problems in pregnant women, which affects nutritional status of the fetus and newborn outcome. The impact of obstetric nutritional risk (ONR) on neonatal morbidity has not been investigated. The purpose of this work was to identify a possible association between ONR, on high-risk pregnancy (HRP) patients and perinatal morbidity.


Methods. This Case Control study included 118 neonates of HRP patients who were either (Cases, n =66) or not (Controls, n =52) with ONR. Groups were then compared to identify associated Neonatal Morbidity. Study variables included: neonatal morbidity, one and five-minute APGAR scores, birth weight, gestation weeks, preterm births, newborn gender and neonatal complications.


Results. Morbidity and preterm births were identified in 40 (60.6%) and 11 (21.1%) neonates (p <0.001); and 40 (60.6%) and 14 (26.9%) neonates (p <0.001), for cases and controls, respectively. Average one-minute and five-minute APGAR scores was 6 ± 1 and 8 ± 1 (p <0.05); and 8 ± 1 and 9 ± 1 (p >0.05) for cases and controls, respectively. Average birth weight and gestation weeks was 2,272.5 and 2,548.5 grams (p <0.05); and 34 ± 3.7 and 37 ± 3 weeks (p <0.05) for cases and controls, respectively. There were 34 (51.51%) and 24 (46.15%) female neonates (p < 0.05); and 32 (48.48%) and 28 (53.85%) male neonates (p >0.05) for cases and control, respectively.


Conclusion. Morbidity was significantly higher in neonates of HRP patients with ONR. Therefore, Obstetric Nutritional Risk had a negative impact on perinatal morbidity and newborn outcome. 

Article Details

How to Cite
ANAYA-PRADO, Roberto et al. Impact of Obstetric Nutritional Risk on Perinatal Morbidity: A Case-Control Study. Medical Research Archives, [S.l.], v. 11, n. 6, june 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3977>. Date accessed: 16 may 2024. doi: https://doi.org/10.18103/mra.v11i6.3977.
Section
Research Articles

References

1. Correia MI, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 2003;22(3):235–9. (DOI: 10.1016/s0261-5614(02)00215-7)
2. McWhirter JP, Pennington CR. Incidence and recognition of malnutrition in hospital. BMJ. 1994;308(6934):945–8. (DOI: 10.1136/bmj.308.6934.945)
3. Marshall NE, Abrams B, Barbour LA, Catalano P, Christian P, Friedman JE, et al.. The importance of nutrition in pregnancy and lactation: Lifelong consequences. Am J Obst GynecoL 2022;226(5):607–32. (DOI: 10.1016/j.ajog.2021.12.035)
4. Salam RA, Das JK, Ali A, Lassi ZS, Bhutta ZA. Maternal undernutrition and intrauterine growth restriction. Expert Rev Obstet Gynecol 2013;8(6):559–67 (DOI:10.1586/17474108.2013.850857)
5. Godfrey K, Robinson S, Barker D, Osmond C, Cox V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 1996;312(7028):410 (DOI: 10.1136/bmj.312.7028.410)
6. Ara KS, Yousuf S, Shume MM, Khatun R, Nasreen B, Mahmood S, et al.. Relationship of the Nutritional Status of Mother Influence Neonatal Outcomes. Sch Int J Obstet Gynec 2021;4(4):166–72. (DOI: 10.36348/sijog.2021.v04i04.015)
7. Wu G, Bazer FW, Cudd TA, Meininger CJ, Spencer TE. Maternal nutrition and fetal development. J. Nutr 2004;134(9):2169–2172 (DOI: 10.1093/jn/134.9.2169)
8. Obanewa O, Newell M-L. Maternal nutritional status during pregnancy and infant immune response to routine childhood vaccinations. Future Virol 2017;12(9):525–36. (DOI: 10.2217/fvl-2017-0021)
9. DeCherney A, Hill M, Carpinello O. Developmental origins of health and disease: The history of the Barker hypothesis and assisted reproductive technology. Semin Reprod Med 2018;36(03/04):177–82. (DOI: 10.1055/s-0038-1675779)
10. Manfredini M. The effects of nutrition on maternal mortality: Evidence from 19th-20th century Italy. SSM - Popul Health 2020;12:100678. (DOI: 10.1016/j.ssmph.2020.100678)
11. Anaya-Prado R, Vianey Torres-Mora LV, Anaya-Fernández MM, Anaya-Fernández R, Izaguirre-Pérez ME, Consuelo C, Azcona-Ramírez CC, et, al.. Obstetric Nutritional Risk Screening in High Risk Pregnancy and its Association with Maternal Morbidity: a Prospective Cohort Study. Clin Obstet Gynecol Reprod Med 2021;7(5):1-7 (DOI:10.15761/COGRM.1000334)
12. Anaya-Prado R, Anaya-Fernández MM, Anaya-Fernández R, Azcona-Ramírez CC. Martínez-Escobar JU, Ochoa-Yudiche DP, et al.. Correlation Between Pregravid Nutritional Status, Obstetric Nutritional Risk and Maternal Morbidity in High Risk Pregnancy: A Case Control Study. World Journal of Gynecology and Women´s Health (World J Gynecol Womens Health) 2022;6(1):1-10 (DOI: 10.33552/WJGWH.2022.06.000626)
13. Romero-Maldonado S, Quezada-Salazar CA, López Barrera MD, Arroyo Cabrales LM. Effect of risk on the child of an older mother (case-control study). Ginecol Obstet Mex. 2002;70:295-302. Spanish. PMID: 12148473.
14. Martínez-Nadal S, Demestre X, Raspall F, Álvarez JA, Elizari MJ, Vila C, et al. Morbilidad neonatal en los recién nacidos a término precoz. An Pediatr (Barc) 2014;81(1):39-44
15. Hernández Núñez J, Valdés Yong M, Suñol Vázquez Yde L, López Quintana Mde L. Maternal and perinatal risk factors for neonatal morbidity: a narrative literature review. Medwave 2015;15(6):e6182 doi: 10.5867/medwave.2015.06.6182
16. Mendoza LA, Arias M, Mendoza LI. Hijo de madre adolescente: riesgos, morbilidad y mortalidad neonatal. Rev Chil Obstet Ginecol 2012;77(5):375-82
17. Victora CG, Christian P, Vidaletti LP, Gatica-Domínguez G, Menon P, Black RE. Revisiting maternal and child undernutrition in low-income and middle-income countries: Variable progress towards an unfinished agenda. Lancet 2021;397(10282):1388–99. (DOI: 10.1016/s0140-6736(21)00394-9)
18. Young MF, Ramakrishnan U. Maternal undernutrition before and during pregnancy and offspring health and development. Ann Nutr Metab 2020;76(Suppl. 3):41–53. (DOI: 10.1159/000510595)
19. NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 2016;387(10026):1377–96. (DOI: 10.1016/S0140-6736(16)30054-X)
20. Bianchi CM, Mariotti F, Verger EO, Huneau JF. Pregnancy requires major changes in the quality of the diet for nutritional adequacy: Simulations in the French and the United States populations. PLoS One 2016;11(3):1-17
21. Khanam R, Lee ASC, Ram M, Quaiyum M, Begum N, Choudhury A, et al. Levels and correlates of nutritional status of women of childbearing age in rural Bangladesh. Public Health Nutr 2018;21(16):3037-3047
22. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Ritcher L, et al.. Maternal and child undernutrition: consequences for adult health and human capital. Lancet 2008;371(9609):340-357
23. Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, et al.. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 2013;382(9890):427–51. (DOI: 10.1016/S0140-6736(13)60937-X)
24. Woldeamanuel GG, Geta TG, Mohammed TP, Shuba MB, Bafa TA. Effect of nutritional status of pregnant women on birth weight of newborns at Butajira Referral Hospital, Butajira, Ethiopia. SAGE Open Med 2019;7:205031211982709. (DOI: 10.1177/2050312119827096)
25. Gala UM, Godhia ML, Nandanwar YS. Effect of maternal nutritional status on birth outcome. Int J Adv Nutr Health Sci 2016;4(1):226–33. (DOI: 10.23953/cloud.ijanhs.142)
26. Wang XY, Zhao P, Frolova AI, Odibo AO, Carter EB, Kelly JC, et al. Diet quality in pregnancy and the risk of fetal growth restriction. Am J Obstet Gynecol 2022;226(1). (DOI: 10.1016/j.ajog.2021.11.081)
27. Dayal S, Fogel Joshua, Griggs R. Adequacy of prenatal care and stillbirth. Minerva Obstet Gynecol 2022;74(1):68-74