Prenatal Stress and Endo-crine Disrupting Chemical Exposure: Hypothalamic-Pituitary-Adrenal Axis Dysregulation as a Mecha-nism for the Health Conse-quences of Both
Main Article Content
Abstract
During the past several decades there has been increasing attention to the risks of exposure to endocrine disrupting chemicals, agents that mimic or block the effects of endogenous hormones. Previous research demonstrates that there may be critical periods of development where factors such as prenatal stress and endocrine disrupting chemical exposure can result in endocrine system dysregulation which manifests both immediately and later in life. This review describes the types of common endocrine disrupting chemicals and routes of exposure, the structure and functions of the hypothalamic-pituitary-adrenal axis and its role in the physiological response to stress, and highlights the current evidence showing that endocrine disrupting chemicals may alter normal hypothalamic-pituitary-adrenal axis functions. These topics are unified upon discussion of evidence indicating that prenatal endocrine disrupting chemical exposure has many of the same effects as prenatal stress on the hypothalamic-pituitary-adrenal axis, leading to long-term dysregulation of the axis and subsequent alterations in physiological responses to stress. We further suggest that prenatal endocrine disrupting chemical exposure in combination with prenatal stress may result in additive, if not synergistic effects on the hypothalamic-pituitary-adrenal axis-mediated stress response. Finally, we discuss vulnerable populations at an elevated risk for dual stress and endocrine disrupting chemical exposure and emphasize critical areas for future research.
Keywords:
Prenatal stress, EDC, HPA axis, cortisol, BPA, poverty
Article Details
How to Cite
HALL, Julianne M.; MERCUGLIANO, Christina; CONTI, Lisa H..
Prenatal Stress and Endo-crine Disrupting Chemical Exposure: Hypothalamic-Pituitary-Adrenal Axis Dysregulation as a Mecha-nism for the Health Conse-quences of Both.
Medical Research Archives, [S.l.], v. 11, n. 6, june 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3985>. Date accessed: 21 nov. 2024.
doi: https://doi.org/10.18103/mra.v11i6.3985.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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8. De Kloet, ER., Joels, M., Holsboer, F. Stress and the brain: From adaptation to disease. Nature Rev Neurosci. 2005;6:463-475.
9. Gold, PW., Chrousos GP. Organization of the stress system and its regulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiat. 2002;7:254-275.
10. Dedic, N., Chen, A., Deussing (2018). The CRF family of neuropeptides and their receptors – mediators of the central stress response. Curr Mol Pharmacol. 2018;11:4-31.
11. McEwen BS, Gianaros PJ. Central role of the brain in stress and adaptation: Links to socio-economic status, health, and disease. Ann NY Acad Sci. 2010;1186:190-222.
12. Vale W, Spiess J, Rivier C, Rivier J. Character-ization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotro-pin and beta-endorphin. Science. 1981;213:1394-1397.
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14. Mbiydzenyuy NE, Hemmings SMJ, Qulu L. Prenatal maternal stress and offspring aggres-sive behavior: Intergenerational and transgenerational inheritance. Front Behav Neurosci. 2022; 16:977416.
15. Timmermans S, Souffriau J, Libert C. A general introduction to glucocorticoid biology. Front Immunol. 2019;10:1545.
16. De Kloet ER, Reul JMHM. Feedback action and tonic influence of corticosteroids on brain func-tion: A concept arising from the heterogeneity of brain receptor systems. Psychoneuroendo-crinol. 1987;12:83-105.
17. Smith SM, Vale WW. The role of the hypotha-lamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8:383-395.
18. Moisiadis VG, Matthews SG. Glucocorticoids and fetal programming 1: outcomes. Nat Rev Endocrinol. 2014;10:391-402.
19. Zhang C, Xu D, MacKay H, Abizaid A. A plu-rality of molecular targets: The receptor eco-system for bisphenol-A (BPA). Horm Behav. 2018;101:59-67.
20. Nicolaides NC, Kyratzi E., Lamprokostopoulou A, Chousos GP, Charmandari E. Stress, the stress system and the role of glucocorticoids. Neuroimmunomod. 2015;22:6-19.
21. Kazakou P, Nicolaides NC, Chrousos GP. Basic concepts and hormonal regulators of the stress system. Horm Res Pediatr. 2023;96:8-16.
22. Brunton PJ. Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring. Reproduc. 2013;146:175-189.
23. Creutzberg KC, Sanson A, Viola TW,Marchisella F, Begni V, Grassi-Oliveira R, Riva MA. Long-lasting effects of prenatal stress on HPA axis and inflammation: A sys-tematic review and multilevel meta-analysis in rodent studies. Neurosci Biobehav Rev. 2021;127:270-283.
24. Harris A, Seckle J. Glucocorticoids, prenatal stress and the programming of disease. Horm Behav. 2011;59:279-289.
25. Howland MA, Sandman CA, Glynn LM. Devel-opmental origins of the human hypothalamic-pituitary-adrenal axis. Expert Rev Endocrinol Metab. 2017;12:321-339.
26. Ruffaner-Hanson C, Noor S, Sun MS, Solomon E, Enriquez Marquez L., Rodriguez DE, Allan AM, Caldwell KK, Bakhireva LN, Milligan ED. The maternal-placental-fetal interface: Adaptations of the HPA axis and immune me-diators following maternal stress and prenatal alcohol. Exper Neurol. 2022;355:114121.
27. Constantinof A, Moisiadis VG, Matthews SG. Programming of stress pathways: A transgen-erational perspective. J Ster Biochem Mol Biol. 2016;160:175-180.
28. Moisiadis VG, Matthews SG. Glucocorticoids and fetal programming part 2: mechanisms. Nat Rev Endocrinol. 2014;10:403-411.
29. Abe H, Hidaka N, Kawagoe C, Odagiri K, Watanabe Y, Ikeda T, Ishizuka Y, Hashiguchi H, Takeda R, Nishimori T, Ishida Y. Prenatal psychological stress causes higher emotionali-ty, depression-like behavior, and elevated ac-tivity in the hypothalamic-pituitary-adrenal axis. Neurosci Res. 2007;59:145-151.
30. Bosch O, Much W, Bredewold R, Slattery DA, Neumann ID. Prenatal stress increases HPA ax-is activity and impairs maternal care in lactat-ing female offspring: Implications for postpar-tum mood disorder. Psychoneuroendocrinol. 2007;32:267-278.
31. Brunton PJ, Russell JA. Prenatal social stress in the rat programmes neuroendocrine and be-havioral responses to stress in the adult off-spring: Sex-specific effects. J Neuroendocrinol. 2010;22:258-271.
32. Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S. Prenatal stress increases the hypo-thalamic-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol. 1994;6:341-345.
33. Jafari Z, Mehla J, Kolb BE, Moharjerani MH. Prenatal noise stress impairs HPA axis and cognitive performance in mice. Scientific Rep. 2017;7:10560.
34. Mueller BR, Bale TL. Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci. 2008;28:9055-9065.
35. Sanchez MM, McCormack K, Grand AP, Fulks R, Graff A, Maestripieri D. Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the cortico-tropin-releasing hormone challenge during the first 3 years of life in group-living rhesus mon-keys. Dev Psychopathol. 2010; 22:45-53.
36. Weinstock M, Matlina E, Maor GI, Rosen H, McEwen BS. Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adren-al system in the female rat. Brain Res. 1992; 595:195-200.
37. McLean MA, Simcock G, Elgbeili G, Laplante DP, Kildea S, Hurrion E, Lequertier B, Cobham VE, King S. Disaster-related prenatal maternal stress, and childhood HPA-axis regulation and anxiety: The QF2011 Queensland flood study. Psychoneuroendocrinol. 2020;118:104716.
38. Bosch OJ, Kromer SA, Neumann ID. Prenatal stress: opposite effects on anxiety and hypo-thalamic expression of vasopressin and corti-cotropin-releasing hormone in rats selectively bred for high and low anxiety. Eur J Neurosci. 2006;23:541-551.
39. Piviana SG, Rakitskaya VV, Akulova VK, Ordyan NE. Activity of the hypothalamic-pituitary-adrenal system in prenatally stress male rats on the experimental model of post-traumatic stress disorder. Bull Exper Biol Med. 2016;160:601-604.
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