Omicron Waves in Few European Countries till June 2022 Modeled by a New Version of a Tracking Approach with Successive and Superimposed Waves

Main Article Content

Pavel Penchev Petkov

Abstract

Our objective is a mathematical modeling in retrospective of the COVID-19 Omicron waves in the UK, France and Germany till mid June 2022. The aim is two-fold: ensure a good reproduction of the data with consistent parameters, also by comparing the results to the ones from an earlier study for the USA, and check the usefulness of a new, improved version of a recently published model. The main novelty of the approach used is the dynamical tracking of successive generations of infected people instead of treating the evolution of few large compartments within which the total population is partitioned. Because of the stronger transmission of Omicron, its waves start to dominate the Pandemic, and then the new model can be easily employed. The formalism is improved by employing better conditions for continuity when interconnecting solutions of differential equations and a superposition of waves related to independent pathogens. The daily observed new infection cases are described over a large time scale in a reasonable way after normalization, with deviations and differences due to country-specific factors. The time-position of the first calculated Pandemic peaks indicates a transition from the third to the fourth generation of infected people. The derived infection and recovery rates are consistent with those deduced for the USA. A correlation exists between initialization of relaxing restrictions and begin of a new wave or simply a jump up of the data locally. However, very often it happens nearby that a new independent wave emerges related to a different variant of the pathogen. Another important result is that describing in a reasonable way Epidemics by using consecutive waves and superposition of waves caused by different pathogen variants opens the possibility to investigate the COVID-19 Pandemic in its full time range, since early 2020 to present. In the future, we intend to work on that problem to obtain additional useful information on that particular Pandemic in some country (or region) and to develop further the model (and software) toward readiness to meet next possible challenges when they come.

Article Details

How to Cite
PETKOV, Pavel Penchev. Omicron Waves in Few European Countries till June 2022 Modeled by a New Version of a Tracking Approach with Successive and Superimposed Waves. Medical Research Archives, [S.l.], v. 11, n. 7.1, july 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4080>. Date accessed: 23 nov. 2024. doi: https://doi.org/10.18103/mra.v11i7.1.4080.
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Research Articles

References

WHO. Weekly epidemiological and operational updates January 2022. https://wwwwhoint/emergencies/diseases/novel-coronavirus-2019/situation-reports.
WHO. Corona virus disease (COVID-19). https://wwwwhoint/docs/default- source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19pdf?sfvrsn=2146841e-2. Accessed Date: March 20, 2020.
WHO. Classification of omicron (b.1.1.529): SARS-CoV-2 variant of concern, 2021. https://wwwwhoint/news/item/26-11-2021-classification-of-omicron-(b11529)-sars-cov-2-variant-of-concern. Accessed date: November 26, 2021.
Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Tuttle KS, Marquez AC, Sekirov I, Sbramaniam S. SARS-CoV-2 omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex. Science 2022;374, 760–764.
Arora S, et. al. Literature review of omicron: A grim reality amidst COVID-19. Microorganims 2022; 10, 451.
WHO. Enhancing response to omicron SARS-CoV-2 variant. https://wwwwhoint/publications/m/item/enhancing-readiness-for-omicron-(b11529)-technical-brief-and-priority-actions-for-member-states. Accessed date: January 21, 2022.
WHO. Statement on the fifteenth meeting of the IHR (2005) emergency committee on the COVID-19 pandemic. https://wwwwhoint/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic. Accessed date: May 5, 2023
Petkov P. New and simple mathematical description of epidemics including consecutive waves. Stud Appl Math 2021;148, 1339–1363.
Kermack WO, McKendrick AG. A contribution to the mathematical theory of epidemics. Proc Royal Soc A 1927;115, 700–721.
Chang SL, Harding N, Zacherson C, Cliff OC, Prokopenko M. Modelling transmission and control of the COVID-19 pandemic in Australia. Nature Communications 2020;11, 5710.
Anderson RM, Heesterbeek H, Klinkenberg D, Hullingsworth TD. How will country-based mitigation measures influences the course of the COVID-19 epidemic? Lancet 2020;3959, 31–934.
Weitz JS et al. Modeling shield immunity to reduce COVID-19 epidemic spread. Nature Medicine 2020;26, 849–854.
Our world in data. https://ourworldindataorg/coronavirus-testing.
Delamater PL, Street EJ, Leslie TF, Yang YT, Jacobsen KH. Complexity of the basic reproduction number (R_0). CDC EID 2019, 25; 17.
Diekmann O, Heesterbeek JAP, Metz JAJ. On the definition and the computation of the basic reproduction ratio r_0 in models for infectious diseases in heterogeneous populations. J Math Biol 1990; 283, 65–382.
Fine EM. Herd immunity: History, theory, practice. Epid Rev 1993;15, 265-302.
Dietz K. The estimation of the basic reproduction number for infectious diseases. Stat Meth Med Res 1993;2, 23–41.
Thakur V, Ratho RK. OMICRON (b.1.1.529): A new SARS-CoV-2 variant of concern mounting worldwide fear. J Med Virol 2022;94, 1821–1824.
Vogel G. New subvariants are masters of immune evasion. Science 2022;376, 679–680.