Primary treatment of Graves’ disease: Comparison of radioiodine and antithyroid drugs.
Main Article Content
Abstract
Abstract
Thyrotoxicosis is a common condition, most frequently due to an autoimmune aetiology (Graves’ disease). There are three treatment options, antithyroid drugs (ATD), radioactive iodine (RI) or thyroidectomy, each with their own benefits and short-comings. Classically surgery is only used as primary treatment of Graves’ disease in patients with compressive symptoms or for cosmetic reasons with the majority of patients treated primarily with either RI or ATD. In this review I will discuss and compare these two treatment modalities (RI and ATD), focussing on efficacy, safety, side-effects, cost and quality of life. Graves’ orbitopathy (GO) is a rare, but potentially sight-threatening orbital manifestation of Graves’ disease and the relationship between ATD, RI and GO is also discussed. ATD are the only treatment modality presently available to have beneficial effects on the autoimmune aetiology by reducing TSH receptor antibody titre. I discuss novel agents which may have utility in the future. In conclusion, RI and ATD are both appropriate primary treatment modalities. Further research is require to identify more effective treatments aimed at ameliorating the autoimmune aetiology of Graves’ disease.
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How to Cite
WALLACE, Ian Robert.
Primary treatment of Graves’ disease: Comparison of radioiodine and antithyroid drugs..
Medical Research Archives, [S.l.], v. 2, n. 5, nov. 2015.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/410>. Date accessed: 23 nov. 2024.
Keywords
Graves’ disease; Hyperthyroidism; Radioactive iodine; Methimazole; Carbimazole; Propylthiouracil; Graves’ orbitopathy
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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