The Efficacy of Hyperbaric Oxygen Therapy in Traumatic Brain Injury Patients: Literature Review and Clinical Guidelines
Main Article Content
Abstract
Introduction: The application of hyperbaric oxygen therapy for patients with both acute and chronic traumatic brain injury has been suggested for over five decades. In the past decade, the design and quality of studies were more detailed and thorough leading to an improved unerstanding of the uses of HBOT and the profiles of the patients who can benefit the most.
Objectives: Perform a comprehensive literature review of hyperbaric oxygen therapy application for the treatment of patients with both acute, subacute and chronic traumatic brain injury.
Methods: Extensive literature search from 1969 to April 2023 was performed on April 1st 2023 within the following databases: Cochrane Library, PubMed, Google Scholar, and Web of Science, including humans clinical data, in articles providing information on the type of treatment and clinical outcomes. Articles were first categorized into acute-subacute traumatic brain inury and chronic traumatic brain injury and further classified into low, medium or high level quality.
Results: There was high level evidence including nine randomized controlled trials, one meta-analysis and two prospective study evaluating the clinical effects of hyperbaric oxygen therapy in patients suffering from traumatic brain injuries in the acute and subacute settings. Mortality was significantly reduced in all studies that used it as an endpoint, while favorable functional outcomes in survivors showed mixed results.
In chronic severe traumatic brain injury, there is low to moderate evidence including two uncontrolled prospective studies, two cohort studies and eight case reports suggesting improved outcomes.
In chronic mild traumatic brain injury, there is high level evidence including seven randomized controlled trials, and six prospective studies suggesting significant improvement in cognitive function, symptoms and quality of life.
Conclusions: Hyperbaric oxygen therapy may be recommended in acute moderate-severe traumatic brain injury patients (Type 2a recommendation, level A evidence). However, further studies are needed to both evaluate outcomes and to determine the optimal treatment protocols for the different types of injuries (Type 1 recommendation, level A evidence).
Hyperbaric oxygen threrapy should be recommended in chronic traumatic brain injury for a selected group of patients suffering from prolonged post-concussion syndrome who have clear evidence of metabolic dysfunctional brain regions as determined by neuroimaging (Type 2a recommendation, level B-R evidence). Patients should be properly evaluated by standardized cognitive tests and functional brain imaging (Type 1 recommendation, level B-R evidence).
Article Details
How to Cite
HADANNY, Amir; MAROON, Joseph; EFRATI, Shai.
The Efficacy of Hyperbaric Oxygen Therapy in Traumatic Brain Injury Patients: Literature Review and Clinical Guidelines.
Medical Research Archives, [S.l.], v. 11, n. 7.2, july 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/4161>. Date accessed: 09 may 2024.
doi: https://doi.org/10.18103/mra.v11i7.2.4161.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Andriessen TM, Horn J, Franschman G, et al. Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study. Journal of neurotrauma. 2011;28(10):2019-2031.
2. Chiu WT, LaPorte RE. Global Spine and Head Injury Prevention (SHIP) Project. The Journal of trauma. 1993;35(6):969-970.
3. Flanagan SR. Invited Commentary on "Centers for Disease Control and Prevention Report to Congress: Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation". Arch Phys Med Rehabil. 2015;96(10):1753-1755.
4. Schootman M, Fuortes LJ. Ambulatory care for traumatic brain injuries in the US, 1995-1997. Brain injury. 2000;14(4):373-381.
5. Warden D. Military TBI during the Iraq and Afghanistan wars. The Journal of head trauma rehabilitation. 2006;21(5):398-402.
6. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. The Journal of head trauma rehabilitation. 2006;21(5):375-378.
7. Sosin DM, Sniezek JE, Thurman DJ. Incidence of mild and moderate brain injury in the United States, 1991. Brain injury. 1996;10(1):47-54.
8. McDonagh M, Carson S, Ash J, et al. Hyperbaric oxygen therapy for brain injury, cerebral palsy, and stroke. Evidence report/technology assessment. 2003(85):1-6.
9. Report to Congress on Mild Traumatic Brain
Injury in the United States: Steps to Prevent a Serious Public Health Problem. . National Center for Injury Prevention and Control. 2003.
10. Malec JF, Brown AW, Leibson CL, et al. The mayo classification system for traumatic brain injury severity. Journal of neurotrauma. 2007;24(9):1417-1424.
11. Bazarian JJ, Wong T, Harris M, Leahey N, Mookerjee S, Dombovy M. Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. Brain injury: [BI]. 1999;13(3):173-189.
12. McCauley SR, Boake C, Pedroza C, et al. Postconcussional disorder: Are the DSM-IV criteria an improvement over the ICD-10? The Journal of nervous and mental disease. 2005;193(8):540-550.
13. Kashluba S, Paniak C, Blake T, Reynolds S, Toller-Lobe G, Nagy J. A longitudinal, controlled study of patient complaints following treated mild traumatic brain injury. Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists. 2004;19(6):805-816.
14. Iverson GL. Outcome from mild traumatic brain injury. Current opinion in psychiatry. 2005;18(3):301-317.
15. Bohnen N, Jolles J, Twijnstra A. Neuropsychological deficits in patients with persistent symptoms six months after mild head injury. Neurosurgery. 1992;30(5):692-695; discussion 695-696.
16. Bazarian JJ, McClung J, Shah MN, Cheng YT, Flesher W, Kraus J. Mild traumatic brain injury in the United States, 1998--2000. Brain injury: [BI]. 2005;19(2):85-91.
17. Murray GD, Teasdale GM, Braakman R, et al. The European Brain Injury Consortium survey of head injuries. Acta neurochirurgica. 1999;141(3):223-236.
18. Crooks CY, Zumsteg JM, Bell KR. Traumatic brain injury: a review of practice management and recent advances. Physical medicine and rehabilitation clinics of North America. 2007;18(4):681-710, vi.
19. Meythaler JM, Peduzzi JD, Eleftheriou E, Novack TA. Current concepts: diffuse axonal injury-associated traumatic brain injury. Archives of physical medicine and rehabilitation. 2001;82(10):1461-1471.
20. Levine B, Fujiwara E, O'Connor C, et al. In vivo characterization of traumatic brain injury neuropathology with structural and functional neuroimaging. Journal of neurotrauma. 2006;23(10):1396-1411.
21. Stone JR, Okonkwo DO, Dialo AO, et al. Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury. Experimental neurology. 2004;190(1):59-69.
22. Fiskum G. Mitochondrial participation in ischemic and traumatic neural cell death. Journal of neurotrauma. 2000;17(10):843-855.
23. Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery. 1996;38(6):1176-1195.
24. Barkhoudarian G, Hovda DA, Giza CC. The Molecular Pathophysiology of Concussive Brain Injury - an Update. Phys Med Rehabil Clin N Am. 2016;27(2):373-393.
25. Farkas O, Lifshitz J, Povlishock JT. Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury? J Neurosci. 2006;26(12):3130-3140.
26. Katayama Y, Becker DP, Tamura T, Hovda DA. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg. 1990;73(6):889-900.
27. Rana P, Rama Rao KV, Ravula A, et al. Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics. 2020;16(3):39.
28. Xu Y, McArthur DL, Alger JR, et al. Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury. J Cereb Blood Flow Metab. 2010;30(4):883-894.
29. Khodorov B, Pinelis V, Storozhevykh T, Vergun O, Vinskaya N. Dominant role of mitochondria in protection against a delayed neuronal Ca2+ overload induced by endogenous excitatory amino acids following a glutamate pulse. FEBS Lett. 1996;393(1):135-138.
30. Lazzarino G, Amorini AM, Signoretti S, et al. Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement. Int J Mol Sci. 2019;20(22).
31. Pandya JD, Leung LY, Yang X, et al. Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI. Front Neurol. 2019;10:605.
32. Albert-Weissenberger C, Siren AL. Experimental traumatic brain injury. Exp Transl Stroke Med. 2010;2(1):16.
33. Maroon JC, Lepere DB, Blaylock RL, Bost JW. Postconcussion syndrome: a review of pathophysiology and potential nonpharmacological approaches to treatment. Phys Sportsmed. 2012;40(4):73-87.
34. Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW. Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury. Compr Physiol. 2015;5(3):1147-1160.
35. Hiebert JB, Shen Q, Thimmesch AR, Pierce JD. Traumatic brain injury and mitochondrial dysfunction. Am J Med Sci. 2015;350(2):132-138.
36. Poulose N, Raju R. Aging and injury: alterations in cellular energetics and organ function. Aging Dis. 2014;5(2):101-108.
37. Jullienne A, Obenaus A, Ichkova A, Savona-Baron C, Pearce WJ, Badaut J. Chronic cerebrovascular dysfunction after traumatic brain injury. J Neurosci Res. 2016;94(7):609-622.
38. Len TK, Neary JP. Cerebrovascular pathophysiology following mild traumatic brain injury. Clin Physiol Funct Imaging. 2011;31(2):85-93.
39. Junger EC, Newell DW, Grant GA, et al. Cerebral autoregulation following minor head injury. J Neurosurg. 1997;86(3):425-432.
40. Strebel S, Lam AM, Matta BF, Newell DW. Impaired cerebral autoregulation after mild brain injury. Surg Neurol. 1997;47(2):128-131.
41. Golding EM, Robertson CS, Bryan RM, Jr. The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens. 1999;21(4):299-332.
42. Yoshino A, Hovda DA, Kawamata T, Katayama Y, Becker DP. Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res. 1991;561(1):106-119.
43. Tavazzi B, Signoretti S, Lazzarino G, et al. Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats. Neurosurgery. 2005;56(3):582-589; discussion 582-589.
44. Guilfoyle MR, Helmy A, Donnelly J, et al. Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients. PLoS One. 2021;16(12):e0260291.
45. Ginsberg MD, Zhao W, Alonso OF, Loor-Estades JY, Dietrich WD, Busto R. Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am J Physiol. 1997;272(6 Pt 2):H2859-2868.
46. Moore AH, Osteen CL, Chatziioannou AF, Hovda DA, Cherry SR. Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J Cereb Blood Flow Metab. 2000;20(10):1492-1501.
47. Thoenen H. Neurotrophins and neuronal plasticity. Science. 1995;270(5236):593-598.
48. Tyler WJ, Pozzo-Miller LD. BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci. 2001;21(12):4249-4258.
49. Takei N, Sasaoka K, Inoue K, Takahashi M, Endo Y, Hatanaka H. Brain-derived neurotrophic factor increases the stimulation-evoked release of glutamate and the levels of exocytosis-associated proteins in cultured cortical neurons from embryonic rats. J Neurochem. 1997;68(1):370-375.
50. Alderson P, Roberts I. Corticosteroids for acute traumatic brain injury. The Cochrane database of systematic reviews. 2005(1):CD000196.
51. Schierhout G, Roberts I. Hyperventilation therapy for acute traumatic brain injury. The Cochrane database of systematic reviews. 2000(2):CD000566.
52. Roberts I, Sydenham E. Barbiturates for acute traumatic brain injury. The Cochrane database of systematic reviews. 2012;12:CD000033.
53. Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan K. Calcium channel blockers for acute traumatic brain injury. The Cochrane database of systematic reviews. 2003(4):CD000565.
54. Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. The Cochrane database of systematic reviews. 2009(2):CD001048.
55. Bullock MR, Povlishock JT. Guidelines for the management of severe traumatic brain injury. Editor's Commentary. Journal of neurotrauma. 2007;24 Suppl 1:2 p preceding S1.
56. Bulger EM, Nathens AB, Rivara FP, et al. Management of severe head injury: institutional variations in care and effect on outcome. Critical care medicine. 2002;30(8):1870-1876.
57. Shafi S, Barnes SA, Millar D, et al. Suboptimal compliance with evidence-based guidelines in patients with traumatic brain injuries. Journal of neurosurgery. 2014;120(3):773-777.
58. Turner-Stokes L, Disler PB, Nair A, Wade DT. Multi-disciplinary rehabilitation for acquired brain injury in adults of working age. The Cochrane database of systematic reviews. 2005(3):CD004170.
59. Greenwald BD, Rigg JL. Neurorehabilitation in traumatic brain injury: does it make a difference? The Mount Sinai journal of medicine, New York. 2009;76(2):182-189.
60. deGuise E, leBlanc J, Feyz M, et al. Long-term outcome after severe traumatic brain injury: the McGill interdisciplinary prospective study. The Journal of head trauma rehabilitation. 2008;23(5):294-303.
61. Dikmen SS, Machamer JE, Powell JM, Temkin NR. Outcome 3 to 5 years after moderate to severe traumatic brain injury. Archives of physical medicine and rehabilitation. 2003;84(10):1449-1457.
62. Hoofien D, Gilboa A, Vakil E, Donovick PJ. Traumatic brain injury (TBI) 10-20 years later: a comprehensive outcome study of psychiatric symptomatology, cognitive abilities and psychosocial functioning. Brain injury. 2001;15(3):189-209.
63. Colantonio A, Ratcliff G, Chase S, Kelsey S, Escobar M, Vernich L. Long-term outcomes after moderate to severe traumatic brain injury. Disability and rehabilitation. 2004;26(5):253-261.
64. Arciniegas DB, Anderson CA, Topkoff J, McAllister TW. Mild traumatic brain injury: a neuropsychiatric approach to diagnosis, evaluation, and treatment. Neuropsychiatric disease and treatment. 2005;1(4):311-327.
65. JP. M. Cerebral blood flow, cerebral blood volume and cerebral metabolism after severe head injury. Textbook of Head Injury
1989;Philadelphia: WB Saunders:221–240.
66. Ikeda Y, Long DM. The molecular basis of brain injury and brain edema: the role of oxygen free radicals. Neurosurgery. 1990;27(1):1-11.
67. Kan EM, Ling EA, Lu J. Microenvironment changes in mild traumatic brain injury. Brain research bulletin. 2012;87(4-5):359-372.
68. Robertson CS, Narayan RK, Gokaslan ZL, et al. Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients. Journal of neurosurgery. 1989;70(2):222-230.
69. Palzur E, Vlodavsky E, Mulla H, Arieli R, Feinsod M, Soustiel JF. Hyperbaric oxygen therapy for reduction of secondary brain damage in head injury: an animal model of brain contusion. Journal of neurotrauma. 2004;21(1):41-48.
70. Harch PG, Kriedt C, Van Meter KW, Sutherland RJ. Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury. Brain research. 2007;1174:120-129.
71. Palzur E, Zaaroor M, Vlodavsky E, Milman F, Soustiel JF. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain research. 2008;1221:126-133.
72. Daugherty WP, Levasseur JE, Sun D, Rockswold GL, Bullock MR. Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats. Journal of neurosurgery. 2004;101(3):499-504.
73. Zhang Y, Yang Y, Tang H, et al. Hyperbaric oxygen therapy ameliorates local brain metabolism, brain edema and inflammatory response in a blast-induced traumatic brain injury model in rabbits. Neurochemical research. 2014;39(5):950-960.
74. Niklas A, Brock D, Schober R, Schulz A, Schneider D. Continuous measurements of cerebral tissue oxygen pressure during hyperbaric oxygenation--HBO effects on brain edema and necrosis after severe brain trauma in rabbits. J Neurol Sci. 2004;219(1-2):77-82.
75. Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients. Journal of neurosurgery. 2001;94(3):403-411.
76. Holbach KH, Caroli A, Wassmann H. Cerebral energy metabolism in patients with brain lesions of normo- and hyperbaric oxygen pressures. Journal of neurology. 1977;217(1):17-30.
77. Nakamura T, Kuroda Y, Yamashita S, et al. Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase. Acta neurochirurgica Supplement. 2008;102:21-24.
78. Neubauer RA, James P. Cerebral oxygenation and the recoverable brain. Neurological research. 1998;20 Suppl 1:S33-36.
79. Rockswold SB, Rockswold GL, Defillo A. Hyperbaric oxygen in traumatic brain injury. Neurological research. 2007;29(2):162-172.
80. Zhou Z, Daugherty WP, Sun D, et al. Protection of mitochondrial function and improvement in cognitive recovery in rats treated with hyperbaric oxygen following lateral fluid-percussion injury. Journal of neurosurgery. 2007;106(4):687-694.
81. Vlodavsky E, Palzur E, Soustiel JF. Hyperbaric oxygen therapy reduces neuroinflammation and expression of matrix metalloproteinase-9 in the rat model of traumatic brain injury. Neuropathology and applied neurobiology. 2006;32(1):40-50.
82. Lim SW, Wang CC, Wang YH, Chio CC, Niu KC, Kuo JR. Microglial activation induced by traumatic brain injury is suppressed by postinjury treatment with hyperbaric oxygen therapy. The Journal of surgical research. 2013;184(2):1076-1084.
83. Lavrnja I, Parabucki A, Brkic P, et al. Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators of inflammation. 2015;2015:498405.
84. Calvert JW, Cahill J, Zhang JH. Hyperbaric oxygen and cerebral physiology. Neurological research. 2007;29(2):132-141.
85. Hills BA. A role for oxygen-induced osmosis in hyperbaric oxygen therapy. Medical hypotheses. 1999;52(3):259-263.
86. Lippert T, Borlongan CV. Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer. CNS Neurosci Ther. 2019;25(8):815-823.
87. Yang Y, Zhang YG, Lin GA, et al. The effects of different hyperbaric oxygen manipulations in rats after traumatic brain injury. Neuroscience letters. 2014;563:38-43.
88. Reinert M, Barth A, Rothen HU, Schaller B, Takala J, Seiler RW. Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury. Acta neurochirurgica. 2003;145(5):341-349; discussion 349-350.
89. Mu J, Ostrowski RP, Soejima Y, et al. Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury. Neurobiology of disease. 2013;51:133-143.
90. Yang YJ, Wang XL, Yu XH, Wang X, Xie M, Liu CT. Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2008;35(2):113-129.
91. Chang CC, Lee YC, Chang WN, et al. Damage of white matter tract correlated with neuropsychological deficits in carbon monoxide intoxication after hyperbaric oxygen therapy. Journal of neurotrauma. 2009;26(8):1263-1270.
92. Vilela DS, Lazarini PR, Da Silva CF. Effects of hyperbaric oxygen therapy on facial nerve regeneration. Acta oto-laryngologica. 2008;128(9):1048-1052.
93. Haapaniemi T, Nylander G, Kanje M, Dahlin L. Hyperbaric oxygen treatment enhances regeneration of the rat sciatic nerve. Experimental neurology. 1998;149(2):433-438.
94. Bradshaw PO, Nelson AG, Fanton JW, Yates T, Kagan-Hallet KS. Effect of hyperbaric oxygenation on peripheral nerve regeneration in adult male rabbits. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 1996;23(2):107-113.
95. Mukoyama M, Iida M, Sobue I. Hyperbaric oxygen therapy for peripheral nerve damage induced in rabbits with clioquinol. Experimental neurology. 1975;47(3):371-380.
96. Zhang JH, Lo T, Mychaskiw G, Colohan A. Mechanisms of hyperbaric oxygen and neuroprotection in stroke. Pathophysiology: the official journal of the International Society for Pathophysiology / ISP. 2005;12(1):63-77.
97. Günther A, Küppers-Tiedt L, Schneider PM, et al. Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci. 2005;21(11):3189-3194.
98. Duan S, Shao G, Yu L, Ren C. Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Int J Neurosci. 2014.
99. Peng ZR, Yang AL, Yang QD. The effect of hyperbaric oxygen on intracephalic angiogenesis in rats with intracerebral hemorrhage. J Neurol Sci. 2014;342(1-2):114-123.
100. Lin KC, Niu KC, Tsai KJ, et al. Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. J Trauma Acute Care Surg. 2012;72(3):650-659.
101. Kuffler DP. The role of hyperbaric oxygen therapy in enhancing the rate of wound healing with a focus on axon regeneration. Puerto Rico health sciences journal. 2011;30(1):35-42.
102. Lin KC, Niu KC, Tsai KJ, et al. Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. J Trauma Acute Care Surg. 2012;72(3):650-659.
103. Kim J, Whyte J, Patel S, et al. Resting cerebral blood flow alterations in chronic traumatic brain injury: an arterial spin labeling perfusion FMRI study. Journal of neurotrauma. 2010;27(8):1399-1411.
104. Graham DI, Adams JH. Ischaemic brain damage in fatal head injuries. Lancet. 1971;1(7693):265-266.
105. Graham DI, Adams JH, Doyle D. Ischaemic brain damage in fatal non-missile head injuries. Journal of the neurological sciences. 1978;39(2-3):213-234.
106. Ostergaard L, Engedal TS, Aamand R, et al. Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014;34(10):1585-1598.
107. Stein SC, Graham DI, Chen XH, Smith DH. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery. 2004;54(3):687-691; discussion 691.
108. Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003;92(6):692-699.
109. Jiang Q, Zhang ZG, Ding GL, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. NeuroImage. 2005;28(3):698-707.
110. Prakash A, Parelkar SV, Oak SN, et al. Role of hyperbaric oxygen therapy in severe head injury in children. Journal of pediatric neurosciences. 2012;7(1):4-8.
111. Mitani M. Brain "implications for HBO2". Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2004;31(1):163-166.
112. Lee CH, Chen WC, Wu CI, Hsia TC. Tension pneumocephalus: a rare complication after hyperbaric oxygen therapy. The American journal of emergency medicine. 2009;27(2):257 e251-253.
113. Mogami H, Hayakawa T, Kanai N, et al. Clinical application of hyperbaric oxygenation in the treatment of acute cerebral damage. Journal of neurosurgery. 1969;31(6):636-643.
114. Zhong X, Shan A, Xu J, Liang J, Long Y, Du B. Hyperbaric oxygen for severe traumatic brain injury: a randomized trial. J Int Med Res. 2020;48(10):300060520939824.
115. Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen. Journal of neurosurgery. 1992;76(6):929-934.
116. Rockswold SB, Rockswold GL, Zaun DA, et al. A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury. Journal of neurosurgery. 2010;112(5):1080-1094.
117. Rockswold SB, Rockswold GL, Zaun DA, Liu J. A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. Journal of neurosurgery. 2013;118(6):1317-1328.
118. Ren H, Wang W, Ge Z. Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. 2001;4(4):239-241.
119. Ren H, Wang W, Ge Z, Zhang J. Clinical, brain electric earth map, endothelin and transcranial ultrasonic Doppler findings after hyperbaric oxygen treatment for severe brain injury. Chinese medical journal. 2001;114(4):387-390.
120. Y. MJ-HSZ-SX. Observation of curative effects of hyperbaric oxygen for treatment on severe craniocerebral injury. Journal of clinical neurology. 2010.
121. Lin JW, Tsai JT, Lee LM, et al. Effect of hyperbaric oxygen on patients with traumatic brain injury. Acta neurochirurgica Supplement. 2008;101:145-149.
122. al Xe. Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study. Neural regeneration research. 2007:304-307.
123. Artru F, Chacornac R, Deleuze R. Hyperbaric oxygenation for severe head injuries. Preliminary results of a controlled study. European neurology. 1976;14(4):310-318.
124. Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. The Cochrane database of systematic reviews. 2012;12:CD004609.
125. Lu Y, Zhou X, Cheng J, Ma Q. Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury. Adv Wound Care (New Rochelle). 2021;10(12):663-670.
126. Sahni T, Jain M, Prasad R, Sogani SK, Singh VP. Use of hyperbaric oxygen in traumatic brain injury: retrospective analysis of data of 20 patients treated at a tertiary care centre. British journal of neurosurgery. 2012;26(2):202-207.
127. Wright JK, Zant E, Groom K, Schlegel RE, Gilliland K. Case report: Treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2009;36(6):391-399.
128. Lv LQ, Hou LJ, Yu MK, Ding XH, Qi XQ, Lu YC. Hyperbaric oxygen therapy in the management of paroxysmal sympathetic hyperactivity after severe traumatic brain injury: a report of 6 cases. Archives of physical medicine and rehabilitation. 2011;92(9):1515-1518.
129. Hardy P, Johnston KM, De Beaumont L, et al. Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury. Journal of the neurological sciences. 2007;253(1-2):94-105.
130. Woolley SM, Lawrence JA, Hornyak J. The effect of hyperbaric oxygen treatment on postural stability and gait of a brain injured patient: single case study. Pediatric rehabilitation. 1999;3(3):81-90.
131. Neubauer RA, Gottlieb SF, Pevsner NH. Hyperbaric oxygen for treatment of closed head injury. South Med J. 1994;87(9):933-936.
132. Lee LC, Lieu FK, Chen YH, Hung TH, Chen SF. Tension pneumocephalus as a complication of hyperbaric oxygen therapy in a patient with chronic traumatic brain injury. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. 2012;91(6):528-532.
133. Skiba M, Rekas-Dudziak A, Bekala A, Plotek W. Late application of hyperbaric oxygen therapy during the rehabilitation of a patient with severe cognitive impairment after a traumatic brain injury. Clin Case Rep. 2021;9(2):960-965.
134. White RD, Turner RP, Arnold N, Bernica A, Lewis BN, Swatzyna RJ. Treating Severe Traumatic Brain Injury: Combining Neurofeedback and Hyperbaric Oxygen Therapy in a Single Case Study. Clin EEG Neurosci. 2021:15500594211068255.
135. Churchill S, Weaver LK, Deru K, et al. A prospective trial of hyperbaric oxygen for chronic sequelae after brain injury (HYBOBI). Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2013;40(2):165-193.
136. Barrett KF, Masel B, Patterson J, Scheibel RS, Corson KP, Mader JT. Regional CBF in chronic stable TBI treated with hyperbaric oxygen. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2004;31(4):395-406.
137. Harch PG, Fogarty EF, Staab PK, Van Meter K. Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report. Cases journal. 2009;2:6538.
138. Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387.
139. Tal S, Hadanny A, Berkovitz N, Sasson E, Ben-Jacob E, Efrati S. Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury. Restorative neurology and neuroscience. 2015.
140. Shi XY, Tang ZQ, Sun D, He XJ. Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury. Chinese medical journal. 2006;119(23):1978-1982.
141. Harch PG, Andrews SR, Fogarty EF, et al. A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. Journal of neurotrauma. 2012;29(1):168-185.
142. Shandley S, Wolf EG, Schubert-Kappan CM, et al. Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy. Undersea Hyperb Med. 2017;44(3):257-269.
143. Shytle RD, Eve DJ, Kim SH, Spiegel A, Sanberg PR, Borlongan CV. Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy. Cell Transplant. 2019;28(7):885-892.
144. Golden Z, Golden CJ, Neubauer RA. Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disability and rehabilitation. 2006;28(22):1379-1386.
145. Shi XY, Tang ZQ, Xiong B, et al. Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status. Chin J Traumatol. 2003;6(6):346-349.
146. Hart BB, Weaver LK, Gupta A, et al. Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies. Undersea Hyperb Med. 2019;46(3):353-383.
147. Harch PG, Andrews SR, Fogarty EF, Lucarini J, Van Meter KW. Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Med Gas Res. 2017;7(3):156-174.
148. Mozayeni BR, Duncan W, Zant E, Love TL, Beckman RL, Stoller KP. The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms. Med Gas Res. 2019;9(1):1-12.
149. Biggs AT, Dainer HM, Littlejohn LF. Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy. J Appl Physiol (1985). 2021;130(5):1594-1603.
150. Ablin JN, Lang E, Catalogna M, et al. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial. PLoS One. 2023;18(3):e0282406.
151. Wolf G, Cifu D, Baugh L, Carne W, Profenna L. The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury. Journal of neurotrauma. 2012;29(17):2606-2612.
152. Cifu DX, Hoke KW, Wetzel PA, Wares JR, Gitchel G, Carne W. Effects of hyperbaric oxygen on eye tracking abnormalities in males after mild traumatic brain injury. Journal of rehabilitation research and development. 2014;51(7):1047-1056.
153. Cifu DX, Hart BB, West SL, Walker W, Carne W. The effect of hyperbaric oxygen on persistent postconcussion symptoms. The Journal of head trauma rehabilitation. 2014;29(1):11-20.
154. Miller RS, Weaver LK, Bahraini N, et al. Effects of hyperbaric oxygen on symptoms and quality of life among service members with persistent postconcussion symptoms: a randomized clinical trial. JAMA internal medicine. 2015;175(1):43-52.
155. Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury - randomized prospective trial. PLoS One. 2013;8(11):e79995.
156. Weaver LK, Wilson SH, Lindblad AS, et al. Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial. Undersea Hyperb Med. 2018;45(2):129-156.
157. Wetzel PA, Lindblad AS, Mulatya C, et al. Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms. Undersea Hyperb Med. 2019;46(3):299-311.
158. Hart BB, Wilson SH, Churchill S, et al. Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. 2019;46(3):313-327.
159. Meehan A, Hebert D, Deru K, Weaver LK. Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms. J Vestib Res. 2019;29(4):205-219.
160. Walker JM, Mulatya C, Hebert D, Wilson SH, Lindblad AS, Weaver LK. Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls. Sleep Med. 2018;51:66-79.
161. Ma J, Hong G, Ha E, et al. Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress. Neurol Sci. 2021;42(10):4131-4138.
162. Harch PG, Andrews SR, Rowe CJ, et al. Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial. Med Gas Res. 2020;10(1):8-20.
163. Hadanny A, Catalogna M, Yaniv S, et al. Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. Sci Rep. 2022;12(1):15233.
164. Churchill S, Deru K, Weaver LK, et al. Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. 2019;46(3):331-340.
165. hadanny A, Meir O, Bechor Y, Fishlev G, Bergan J, Efrati S. The safety of hyperbaric oxygen treatment--retrospective analysis in 2,334 patients. Undersea Hyperb Med. 2016;43(2):113-122.
166. Gajewski BJ, Berry SM, Barsan WG, et al. Hyperbaric oxygen brain injury treatment (HOBIT) trial: a multifactor design with response adaptive randomization and longitudinal modeling. Pharm Stat. 2016;15(5):396-404.
167. Faul M, Wald MM, Rutland-Brown W, Sullivent EE, Sattin RW. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing theBrain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. The Journal of trauma. 2007;63(6):1271-1278.
168. Terri Tanielian JL. Invisible wounds of war:psychological and cognitive injuries, their consequences, and services to assist recovery. RAND Corporation, Center for Military Health Policy Research. 2008.
2. Chiu WT, LaPorte RE. Global Spine and Head Injury Prevention (SHIP) Project. The Journal of trauma. 1993;35(6):969-970.
3. Flanagan SR. Invited Commentary on "Centers for Disease Control and Prevention Report to Congress: Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation". Arch Phys Med Rehabil. 2015;96(10):1753-1755.
4. Schootman M, Fuortes LJ. Ambulatory care for traumatic brain injuries in the US, 1995-1997. Brain injury. 2000;14(4):373-381.
5. Warden D. Military TBI during the Iraq and Afghanistan wars. The Journal of head trauma rehabilitation. 2006;21(5):398-402.
6. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. The Journal of head trauma rehabilitation. 2006;21(5):375-378.
7. Sosin DM, Sniezek JE, Thurman DJ. Incidence of mild and moderate brain injury in the United States, 1991. Brain injury. 1996;10(1):47-54.
8. McDonagh M, Carson S, Ash J, et al. Hyperbaric oxygen therapy for brain injury, cerebral palsy, and stroke. Evidence report/technology assessment. 2003(85):1-6.
9. Report to Congress on Mild Traumatic Brain
Injury in the United States: Steps to Prevent a Serious Public Health Problem. . National Center for Injury Prevention and Control. 2003.
10. Malec JF, Brown AW, Leibson CL, et al. The mayo classification system for traumatic brain injury severity. Journal of neurotrauma. 2007;24(9):1417-1424.
11. Bazarian JJ, Wong T, Harris M, Leahey N, Mookerjee S, Dombovy M. Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. Brain injury: [BI]. 1999;13(3):173-189.
12. McCauley SR, Boake C, Pedroza C, et al. Postconcussional disorder: Are the DSM-IV criteria an improvement over the ICD-10? The Journal of nervous and mental disease. 2005;193(8):540-550.
13. Kashluba S, Paniak C, Blake T, Reynolds S, Toller-Lobe G, Nagy J. A longitudinal, controlled study of patient complaints following treated mild traumatic brain injury. Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists. 2004;19(6):805-816.
14. Iverson GL. Outcome from mild traumatic brain injury. Current opinion in psychiatry. 2005;18(3):301-317.
15. Bohnen N, Jolles J, Twijnstra A. Neuropsychological deficits in patients with persistent symptoms six months after mild head injury. Neurosurgery. 1992;30(5):692-695; discussion 695-696.
16. Bazarian JJ, McClung J, Shah MN, Cheng YT, Flesher W, Kraus J. Mild traumatic brain injury in the United States, 1998--2000. Brain injury: [BI]. 2005;19(2):85-91.
17. Murray GD, Teasdale GM, Braakman R, et al. The European Brain Injury Consortium survey of head injuries. Acta neurochirurgica. 1999;141(3):223-236.
18. Crooks CY, Zumsteg JM, Bell KR. Traumatic brain injury: a review of practice management and recent advances. Physical medicine and rehabilitation clinics of North America. 2007;18(4):681-710, vi.
19. Meythaler JM, Peduzzi JD, Eleftheriou E, Novack TA. Current concepts: diffuse axonal injury-associated traumatic brain injury. Archives of physical medicine and rehabilitation. 2001;82(10):1461-1471.
20. Levine B, Fujiwara E, O'Connor C, et al. In vivo characterization of traumatic brain injury neuropathology with structural and functional neuroimaging. Journal of neurotrauma. 2006;23(10):1396-1411.
21. Stone JR, Okonkwo DO, Dialo AO, et al. Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury. Experimental neurology. 2004;190(1):59-69.
22. Fiskum G. Mitochondrial participation in ischemic and traumatic neural cell death. Journal of neurotrauma. 2000;17(10):843-855.
23. Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery. 1996;38(6):1176-1195.
24. Barkhoudarian G, Hovda DA, Giza CC. The Molecular Pathophysiology of Concussive Brain Injury - an Update. Phys Med Rehabil Clin N Am. 2016;27(2):373-393.
25. Farkas O, Lifshitz J, Povlishock JT. Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury? J Neurosci. 2006;26(12):3130-3140.
26. Katayama Y, Becker DP, Tamura T, Hovda DA. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg. 1990;73(6):889-900.
27. Rana P, Rama Rao KV, Ravula A, et al. Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics. 2020;16(3):39.
28. Xu Y, McArthur DL, Alger JR, et al. Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury. J Cereb Blood Flow Metab. 2010;30(4):883-894.
29. Khodorov B, Pinelis V, Storozhevykh T, Vergun O, Vinskaya N. Dominant role of mitochondria in protection against a delayed neuronal Ca2+ overload induced by endogenous excitatory amino acids following a glutamate pulse. FEBS Lett. 1996;393(1):135-138.
30. Lazzarino G, Amorini AM, Signoretti S, et al. Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement. Int J Mol Sci. 2019;20(22).
31. Pandya JD, Leung LY, Yang X, et al. Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI. Front Neurol. 2019;10:605.
32. Albert-Weissenberger C, Siren AL. Experimental traumatic brain injury. Exp Transl Stroke Med. 2010;2(1):16.
33. Maroon JC, Lepere DB, Blaylock RL, Bost JW. Postconcussion syndrome: a review of pathophysiology and potential nonpharmacological approaches to treatment. Phys Sportsmed. 2012;40(4):73-87.
34. Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW. Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury. Compr Physiol. 2015;5(3):1147-1160.
35. Hiebert JB, Shen Q, Thimmesch AR, Pierce JD. Traumatic brain injury and mitochondrial dysfunction. Am J Med Sci. 2015;350(2):132-138.
36. Poulose N, Raju R. Aging and injury: alterations in cellular energetics and organ function. Aging Dis. 2014;5(2):101-108.
37. Jullienne A, Obenaus A, Ichkova A, Savona-Baron C, Pearce WJ, Badaut J. Chronic cerebrovascular dysfunction after traumatic brain injury. J Neurosci Res. 2016;94(7):609-622.
38. Len TK, Neary JP. Cerebrovascular pathophysiology following mild traumatic brain injury. Clin Physiol Funct Imaging. 2011;31(2):85-93.
39. Junger EC, Newell DW, Grant GA, et al. Cerebral autoregulation following minor head injury. J Neurosurg. 1997;86(3):425-432.
40. Strebel S, Lam AM, Matta BF, Newell DW. Impaired cerebral autoregulation after mild brain injury. Surg Neurol. 1997;47(2):128-131.
41. Golding EM, Robertson CS, Bryan RM, Jr. The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens. 1999;21(4):299-332.
42. Yoshino A, Hovda DA, Kawamata T, Katayama Y, Becker DP. Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res. 1991;561(1):106-119.
43. Tavazzi B, Signoretti S, Lazzarino G, et al. Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats. Neurosurgery. 2005;56(3):582-589; discussion 582-589.
44. Guilfoyle MR, Helmy A, Donnelly J, et al. Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients. PLoS One. 2021;16(12):e0260291.
45. Ginsberg MD, Zhao W, Alonso OF, Loor-Estades JY, Dietrich WD, Busto R. Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am J Physiol. 1997;272(6 Pt 2):H2859-2868.
46. Moore AH, Osteen CL, Chatziioannou AF, Hovda DA, Cherry SR. Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J Cereb Blood Flow Metab. 2000;20(10):1492-1501.
47. Thoenen H. Neurotrophins and neuronal plasticity. Science. 1995;270(5236):593-598.
48. Tyler WJ, Pozzo-Miller LD. BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci. 2001;21(12):4249-4258.
49. Takei N, Sasaoka K, Inoue K, Takahashi M, Endo Y, Hatanaka H. Brain-derived neurotrophic factor increases the stimulation-evoked release of glutamate and the levels of exocytosis-associated proteins in cultured cortical neurons from embryonic rats. J Neurochem. 1997;68(1):370-375.
50. Alderson P, Roberts I. Corticosteroids for acute traumatic brain injury. The Cochrane database of systematic reviews. 2005(1):CD000196.
51. Schierhout G, Roberts I. Hyperventilation therapy for acute traumatic brain injury. The Cochrane database of systematic reviews. 2000(2):CD000566.
52. Roberts I, Sydenham E. Barbiturates for acute traumatic brain injury. The Cochrane database of systematic reviews. 2012;12:CD000033.
53. Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan K. Calcium channel blockers for acute traumatic brain injury. The Cochrane database of systematic reviews. 2003(4):CD000565.
54. Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. The Cochrane database of systematic reviews. 2009(2):CD001048.
55. Bullock MR, Povlishock JT. Guidelines for the management of severe traumatic brain injury. Editor's Commentary. Journal of neurotrauma. 2007;24 Suppl 1:2 p preceding S1.
56. Bulger EM, Nathens AB, Rivara FP, et al. Management of severe head injury: institutional variations in care and effect on outcome. Critical care medicine. 2002;30(8):1870-1876.
57. Shafi S, Barnes SA, Millar D, et al. Suboptimal compliance with evidence-based guidelines in patients with traumatic brain injuries. Journal of neurosurgery. 2014;120(3):773-777.
58. Turner-Stokes L, Disler PB, Nair A, Wade DT. Multi-disciplinary rehabilitation for acquired brain injury in adults of working age. The Cochrane database of systematic reviews. 2005(3):CD004170.
59. Greenwald BD, Rigg JL. Neurorehabilitation in traumatic brain injury: does it make a difference? The Mount Sinai journal of medicine, New York. 2009;76(2):182-189.
60. deGuise E, leBlanc J, Feyz M, et al. Long-term outcome after severe traumatic brain injury: the McGill interdisciplinary prospective study. The Journal of head trauma rehabilitation. 2008;23(5):294-303.
61. Dikmen SS, Machamer JE, Powell JM, Temkin NR. Outcome 3 to 5 years after moderate to severe traumatic brain injury. Archives of physical medicine and rehabilitation. 2003;84(10):1449-1457.
62. Hoofien D, Gilboa A, Vakil E, Donovick PJ. Traumatic brain injury (TBI) 10-20 years later: a comprehensive outcome study of psychiatric symptomatology, cognitive abilities and psychosocial functioning. Brain injury. 2001;15(3):189-209.
63. Colantonio A, Ratcliff G, Chase S, Kelsey S, Escobar M, Vernich L. Long-term outcomes after moderate to severe traumatic brain injury. Disability and rehabilitation. 2004;26(5):253-261.
64. Arciniegas DB, Anderson CA, Topkoff J, McAllister TW. Mild traumatic brain injury: a neuropsychiatric approach to diagnosis, evaluation, and treatment. Neuropsychiatric disease and treatment. 2005;1(4):311-327.
65. JP. M. Cerebral blood flow, cerebral blood volume and cerebral metabolism after severe head injury. Textbook of Head Injury
1989;Philadelphia: WB Saunders:221–240.
66. Ikeda Y, Long DM. The molecular basis of brain injury and brain edema: the role of oxygen free radicals. Neurosurgery. 1990;27(1):1-11.
67. Kan EM, Ling EA, Lu J. Microenvironment changes in mild traumatic brain injury. Brain research bulletin. 2012;87(4-5):359-372.
68. Robertson CS, Narayan RK, Gokaslan ZL, et al. Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients. Journal of neurosurgery. 1989;70(2):222-230.
69. Palzur E, Vlodavsky E, Mulla H, Arieli R, Feinsod M, Soustiel JF. Hyperbaric oxygen therapy for reduction of secondary brain damage in head injury: an animal model of brain contusion. Journal of neurotrauma. 2004;21(1):41-48.
70. Harch PG, Kriedt C, Van Meter KW, Sutherland RJ. Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury. Brain research. 2007;1174:120-129.
71. Palzur E, Zaaroor M, Vlodavsky E, Milman F, Soustiel JF. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain research. 2008;1221:126-133.
72. Daugherty WP, Levasseur JE, Sun D, Rockswold GL, Bullock MR. Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats. Journal of neurosurgery. 2004;101(3):499-504.
73. Zhang Y, Yang Y, Tang H, et al. Hyperbaric oxygen therapy ameliorates local brain metabolism, brain edema and inflammatory response in a blast-induced traumatic brain injury model in rabbits. Neurochemical research. 2014;39(5):950-960.
74. Niklas A, Brock D, Schober R, Schulz A, Schneider D. Continuous measurements of cerebral tissue oxygen pressure during hyperbaric oxygenation--HBO effects on brain edema and necrosis after severe brain trauma in rabbits. J Neurol Sci. 2004;219(1-2):77-82.
75. Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients. Journal of neurosurgery. 2001;94(3):403-411.
76. Holbach KH, Caroli A, Wassmann H. Cerebral energy metabolism in patients with brain lesions of normo- and hyperbaric oxygen pressures. Journal of neurology. 1977;217(1):17-30.
77. Nakamura T, Kuroda Y, Yamashita S, et al. Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase. Acta neurochirurgica Supplement. 2008;102:21-24.
78. Neubauer RA, James P. Cerebral oxygenation and the recoverable brain. Neurological research. 1998;20 Suppl 1:S33-36.
79. Rockswold SB, Rockswold GL, Defillo A. Hyperbaric oxygen in traumatic brain injury. Neurological research. 2007;29(2):162-172.
80. Zhou Z, Daugherty WP, Sun D, et al. Protection of mitochondrial function and improvement in cognitive recovery in rats treated with hyperbaric oxygen following lateral fluid-percussion injury. Journal of neurosurgery. 2007;106(4):687-694.
81. Vlodavsky E, Palzur E, Soustiel JF. Hyperbaric oxygen therapy reduces neuroinflammation and expression of matrix metalloproteinase-9 in the rat model of traumatic brain injury. Neuropathology and applied neurobiology. 2006;32(1):40-50.
82. Lim SW, Wang CC, Wang YH, Chio CC, Niu KC, Kuo JR. Microglial activation induced by traumatic brain injury is suppressed by postinjury treatment with hyperbaric oxygen therapy. The Journal of surgical research. 2013;184(2):1076-1084.
83. Lavrnja I, Parabucki A, Brkic P, et al. Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators of inflammation. 2015;2015:498405.
84. Calvert JW, Cahill J, Zhang JH. Hyperbaric oxygen and cerebral physiology. Neurological research. 2007;29(2):132-141.
85. Hills BA. A role for oxygen-induced osmosis in hyperbaric oxygen therapy. Medical hypotheses. 1999;52(3):259-263.
86. Lippert T, Borlongan CV. Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer. CNS Neurosci Ther. 2019;25(8):815-823.
87. Yang Y, Zhang YG, Lin GA, et al. The effects of different hyperbaric oxygen manipulations in rats after traumatic brain injury. Neuroscience letters. 2014;563:38-43.
88. Reinert M, Barth A, Rothen HU, Schaller B, Takala J, Seiler RW. Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury. Acta neurochirurgica. 2003;145(5):341-349; discussion 349-350.
89. Mu J, Ostrowski RP, Soejima Y, et al. Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury. Neurobiology of disease. 2013;51:133-143.
90. Yang YJ, Wang XL, Yu XH, Wang X, Xie M, Liu CT. Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2008;35(2):113-129.
91. Chang CC, Lee YC, Chang WN, et al. Damage of white matter tract correlated with neuropsychological deficits in carbon monoxide intoxication after hyperbaric oxygen therapy. Journal of neurotrauma. 2009;26(8):1263-1270.
92. Vilela DS, Lazarini PR, Da Silva CF. Effects of hyperbaric oxygen therapy on facial nerve regeneration. Acta oto-laryngologica. 2008;128(9):1048-1052.
93. Haapaniemi T, Nylander G, Kanje M, Dahlin L. Hyperbaric oxygen treatment enhances regeneration of the rat sciatic nerve. Experimental neurology. 1998;149(2):433-438.
94. Bradshaw PO, Nelson AG, Fanton JW, Yates T, Kagan-Hallet KS. Effect of hyperbaric oxygenation on peripheral nerve regeneration in adult male rabbits. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 1996;23(2):107-113.
95. Mukoyama M, Iida M, Sobue I. Hyperbaric oxygen therapy for peripheral nerve damage induced in rabbits with clioquinol. Experimental neurology. 1975;47(3):371-380.
96. Zhang JH, Lo T, Mychaskiw G, Colohan A. Mechanisms of hyperbaric oxygen and neuroprotection in stroke. Pathophysiology: the official journal of the International Society for Pathophysiology / ISP. 2005;12(1):63-77.
97. Günther A, Küppers-Tiedt L, Schneider PM, et al. Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci. 2005;21(11):3189-3194.
98. Duan S, Shao G, Yu L, Ren C. Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Int J Neurosci. 2014.
99. Peng ZR, Yang AL, Yang QD. The effect of hyperbaric oxygen on intracephalic angiogenesis in rats with intracerebral hemorrhage. J Neurol Sci. 2014;342(1-2):114-123.
100. Lin KC, Niu KC, Tsai KJ, et al. Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. J Trauma Acute Care Surg. 2012;72(3):650-659.
101. Kuffler DP. The role of hyperbaric oxygen therapy in enhancing the rate of wound healing with a focus on axon regeneration. Puerto Rico health sciences journal. 2011;30(1):35-42.
102. Lin KC, Niu KC, Tsai KJ, et al. Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. J Trauma Acute Care Surg. 2012;72(3):650-659.
103. Kim J, Whyte J, Patel S, et al. Resting cerebral blood flow alterations in chronic traumatic brain injury: an arterial spin labeling perfusion FMRI study. Journal of neurotrauma. 2010;27(8):1399-1411.
104. Graham DI, Adams JH. Ischaemic brain damage in fatal head injuries. Lancet. 1971;1(7693):265-266.
105. Graham DI, Adams JH, Doyle D. Ischaemic brain damage in fatal non-missile head injuries. Journal of the neurological sciences. 1978;39(2-3):213-234.
106. Ostergaard L, Engedal TS, Aamand R, et al. Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014;34(10):1585-1598.
107. Stein SC, Graham DI, Chen XH, Smith DH. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery. 2004;54(3):687-691; discussion 691.
108. Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003;92(6):692-699.
109. Jiang Q, Zhang ZG, Ding GL, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. NeuroImage. 2005;28(3):698-707.
110. Prakash A, Parelkar SV, Oak SN, et al. Role of hyperbaric oxygen therapy in severe head injury in children. Journal of pediatric neurosciences. 2012;7(1):4-8.
111. Mitani M. Brain "implications for HBO2". Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2004;31(1):163-166.
112. Lee CH, Chen WC, Wu CI, Hsia TC. Tension pneumocephalus: a rare complication after hyperbaric oxygen therapy. The American journal of emergency medicine. 2009;27(2):257 e251-253.
113. Mogami H, Hayakawa T, Kanai N, et al. Clinical application of hyperbaric oxygenation in the treatment of acute cerebral damage. Journal of neurosurgery. 1969;31(6):636-643.
114. Zhong X, Shan A, Xu J, Liang J, Long Y, Du B. Hyperbaric oxygen for severe traumatic brain injury: a randomized trial. J Int Med Res. 2020;48(10):300060520939824.
115. Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen. Journal of neurosurgery. 1992;76(6):929-934.
116. Rockswold SB, Rockswold GL, Zaun DA, et al. A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury. Journal of neurosurgery. 2010;112(5):1080-1094.
117. Rockswold SB, Rockswold GL, Zaun DA, Liu J. A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. Journal of neurosurgery. 2013;118(6):1317-1328.
118. Ren H, Wang W, Ge Z. Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. 2001;4(4):239-241.
119. Ren H, Wang W, Ge Z, Zhang J. Clinical, brain electric earth map, endothelin and transcranial ultrasonic Doppler findings after hyperbaric oxygen treatment for severe brain injury. Chinese medical journal. 2001;114(4):387-390.
120. Y. MJ-HSZ-SX. Observation of curative effects of hyperbaric oxygen for treatment on severe craniocerebral injury. Journal of clinical neurology. 2010.
121. Lin JW, Tsai JT, Lee LM, et al. Effect of hyperbaric oxygen on patients with traumatic brain injury. Acta neurochirurgica Supplement. 2008;101:145-149.
122. al Xe. Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study. Neural regeneration research. 2007:304-307.
123. Artru F, Chacornac R, Deleuze R. Hyperbaric oxygenation for severe head injuries. Preliminary results of a controlled study. European neurology. 1976;14(4):310-318.
124. Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. The Cochrane database of systematic reviews. 2012;12:CD004609.
125. Lu Y, Zhou X, Cheng J, Ma Q. Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury. Adv Wound Care (New Rochelle). 2021;10(12):663-670.
126. Sahni T, Jain M, Prasad R, Sogani SK, Singh VP. Use of hyperbaric oxygen in traumatic brain injury: retrospective analysis of data of 20 patients treated at a tertiary care centre. British journal of neurosurgery. 2012;26(2):202-207.
127. Wright JK, Zant E, Groom K, Schlegel RE, Gilliland K. Case report: Treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2009;36(6):391-399.
128. Lv LQ, Hou LJ, Yu MK, Ding XH, Qi XQ, Lu YC. Hyperbaric oxygen therapy in the management of paroxysmal sympathetic hyperactivity after severe traumatic brain injury: a report of 6 cases. Archives of physical medicine and rehabilitation. 2011;92(9):1515-1518.
129. Hardy P, Johnston KM, De Beaumont L, et al. Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury. Journal of the neurological sciences. 2007;253(1-2):94-105.
130. Woolley SM, Lawrence JA, Hornyak J. The effect of hyperbaric oxygen treatment on postural stability and gait of a brain injured patient: single case study. Pediatric rehabilitation. 1999;3(3):81-90.
131. Neubauer RA, Gottlieb SF, Pevsner NH. Hyperbaric oxygen for treatment of closed head injury. South Med J. 1994;87(9):933-936.
132. Lee LC, Lieu FK, Chen YH, Hung TH, Chen SF. Tension pneumocephalus as a complication of hyperbaric oxygen therapy in a patient with chronic traumatic brain injury. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. 2012;91(6):528-532.
133. Skiba M, Rekas-Dudziak A, Bekala A, Plotek W. Late application of hyperbaric oxygen therapy during the rehabilitation of a patient with severe cognitive impairment after a traumatic brain injury. Clin Case Rep. 2021;9(2):960-965.
134. White RD, Turner RP, Arnold N, Bernica A, Lewis BN, Swatzyna RJ. Treating Severe Traumatic Brain Injury: Combining Neurofeedback and Hyperbaric Oxygen Therapy in a Single Case Study. Clin EEG Neurosci. 2021:15500594211068255.
135. Churchill S, Weaver LK, Deru K, et al. A prospective trial of hyperbaric oxygen for chronic sequelae after brain injury (HYBOBI). Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2013;40(2):165-193.
136. Barrett KF, Masel B, Patterson J, Scheibel RS, Corson KP, Mader JT. Regional CBF in chronic stable TBI treated with hyperbaric oxygen. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2004;31(4):395-406.
137. Harch PG, Fogarty EF, Staab PK, Van Meter K. Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report. Cases journal. 2009;2:6538.
138. Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387.
139. Tal S, Hadanny A, Berkovitz N, Sasson E, Ben-Jacob E, Efrati S. Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury. Restorative neurology and neuroscience. 2015.
140. Shi XY, Tang ZQ, Sun D, He XJ. Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury. Chinese medical journal. 2006;119(23):1978-1982.
141. Harch PG, Andrews SR, Fogarty EF, et al. A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. Journal of neurotrauma. 2012;29(1):168-185.
142. Shandley S, Wolf EG, Schubert-Kappan CM, et al. Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy. Undersea Hyperb Med. 2017;44(3):257-269.
143. Shytle RD, Eve DJ, Kim SH, Spiegel A, Sanberg PR, Borlongan CV. Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy. Cell Transplant. 2019;28(7):885-892.
144. Golden Z, Golden CJ, Neubauer RA. Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disability and rehabilitation. 2006;28(22):1379-1386.
145. Shi XY, Tang ZQ, Xiong B, et al. Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status. Chin J Traumatol. 2003;6(6):346-349.
146. Hart BB, Weaver LK, Gupta A, et al. Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies. Undersea Hyperb Med. 2019;46(3):353-383.
147. Harch PG, Andrews SR, Fogarty EF, Lucarini J, Van Meter KW. Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Med Gas Res. 2017;7(3):156-174.
148. Mozayeni BR, Duncan W, Zant E, Love TL, Beckman RL, Stoller KP. The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms. Med Gas Res. 2019;9(1):1-12.
149. Biggs AT, Dainer HM, Littlejohn LF. Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy. J Appl Physiol (1985). 2021;130(5):1594-1603.
150. Ablin JN, Lang E, Catalogna M, et al. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial. PLoS One. 2023;18(3):e0282406.
151. Wolf G, Cifu D, Baugh L, Carne W, Profenna L. The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury. Journal of neurotrauma. 2012;29(17):2606-2612.
152. Cifu DX, Hoke KW, Wetzel PA, Wares JR, Gitchel G, Carne W. Effects of hyperbaric oxygen on eye tracking abnormalities in males after mild traumatic brain injury. Journal of rehabilitation research and development. 2014;51(7):1047-1056.
153. Cifu DX, Hart BB, West SL, Walker W, Carne W. The effect of hyperbaric oxygen on persistent postconcussion symptoms. The Journal of head trauma rehabilitation. 2014;29(1):11-20.
154. Miller RS, Weaver LK, Bahraini N, et al. Effects of hyperbaric oxygen on symptoms and quality of life among service members with persistent postconcussion symptoms: a randomized clinical trial. JAMA internal medicine. 2015;175(1):43-52.
155. Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury - randomized prospective trial. PLoS One. 2013;8(11):e79995.
156. Weaver LK, Wilson SH, Lindblad AS, et al. Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial. Undersea Hyperb Med. 2018;45(2):129-156.
157. Wetzel PA, Lindblad AS, Mulatya C, et al. Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms. Undersea Hyperb Med. 2019;46(3):299-311.
158. Hart BB, Wilson SH, Churchill S, et al. Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. 2019;46(3):313-327.
159. Meehan A, Hebert D, Deru K, Weaver LK. Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms. J Vestib Res. 2019;29(4):205-219.
160. Walker JM, Mulatya C, Hebert D, Wilson SH, Lindblad AS, Weaver LK. Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls. Sleep Med. 2018;51:66-79.
161. Ma J, Hong G, Ha E, et al. Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress. Neurol Sci. 2021;42(10):4131-4138.
162. Harch PG, Andrews SR, Rowe CJ, et al. Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial. Med Gas Res. 2020;10(1):8-20.
163. Hadanny A, Catalogna M, Yaniv S, et al. Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. Sci Rep. 2022;12(1):15233.
164. Churchill S, Deru K, Weaver LK, et al. Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. 2019;46(3):331-340.
165. hadanny A, Meir O, Bechor Y, Fishlev G, Bergan J, Efrati S. The safety of hyperbaric oxygen treatment--retrospective analysis in 2,334 patients. Undersea Hyperb Med. 2016;43(2):113-122.
166. Gajewski BJ, Berry SM, Barsan WG, et al. Hyperbaric oxygen brain injury treatment (HOBIT) trial: a multifactor design with response adaptive randomization and longitudinal modeling. Pharm Stat. 2016;15(5):396-404.
167. Faul M, Wald MM, Rutland-Brown W, Sullivent EE, Sattin RW. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing theBrain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. The Journal of trauma. 2007;63(6):1271-1278.
168. Terri Tanielian JL. Invisible wounds of war:psychological and cognitive injuries, their consequences, and services to assist recovery. RAND Corporation, Center for Military Health Policy Research. 2008.