Leiomyosarcoma of the Inferior Vena Cava Presenting as Deep Vein Thrombosis
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Abstract
Leiomyosarcoma of the inferior vena cava is a rare smooth muscle sarcoma with a variable presentation. We report a case of inferior vena cava leiomyosarcoma with the sole presenting symptom of lower extremity edema, with an initial diagnosis of deep venous thrombosis. Further evaluation with a venogram and computed tomography scan of the patient’s abdomen and pelvis revealed a wall-adherent filling defect and soft tissue mass and subsequent biopsy revealed leiomyosarcoma of her inferior vena cava. Our patient was treated with a thrombectomy and excision of her tumor and was then provided chemotherapy as an outpatient with resolution of her symptoms. Such a case demonstrates a rare underlying etiology of the common presenting symptom of lower extremity edema.
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References
2. Hilliard NJ, Castro CY. Leiomyosarcoma of the inferior vena cava: Three case reports and review of the literature. In: Heslin MJ, ed. Annals of Diagnostic Pathology. Vol 9. 5th ed; :259-266. doi.org/10.1016/j.anndiagpath.2005.05.001.
3. Serrano C, George S. Leiomyosarcoma. Hematology/Oncology Clinics of North America. 2013;27(5):957-974. doi:10.1016/j.hoc.2013.07.002
4. Popovich JR, Kashyap S, Gasalberti DP, Cassaro S. Sarcoma - statpearls - NCBI bookshelf . National Library of Medicine. May 6, 2023. Accessed July 2, 2023. https://www.ncbi.nlm.nih.gov/books/NBK519533/.
5. Inferior vena cava leiomyosarcoma. Definitions. Published online 2020. doi:10.32388/vilvwg
6. Saikia J, Rastogi S, Barwad A, Dhamija E, Pandey R, Bhoriwal S, Deo S, Kumar S. A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava-Results from analysis of 118 cases. Asian Cardiovasc Thorac Ann. 2022 Mar;30(3): 349-363. doi: 10.1177/02184923211049911. Epub 2021 Oct 21. PMID: 34672808.
7. Suneetha KP, Gudaganatti SB, Gayathri J. Rare case presentation of leiomyosarcoma as IVC thrombus. Indian Journal of Surgical Oncology. 2019;10(3):540-541. doi:10.1007/s13193-019-00939-0 .
8. Xu J, Velayati A, Berger BJ, Liu M, Cheedella NK, Gotlieb V. Leiomyosarcoma of the inferior vena cava in an HIV-positive adult patient: A case report and review of the literature. American Journal of Case Reports. 2017; 18:1160-1165. doi:10.12659/ajcr.905787
9. Arif SH, Mohammed AA. Leiomyosarcoma of the inferior vena cava presenting as deep venous thrombosis; Case report. Radiology Case Reports. 2020;15(2):133-135. doi:10.1016/j.radcr.2019.10.034
10. Oliveira N, Dias E, Lima R, Oliveira F, Cássio I. Primary iliac venous leiomyosarcoma: A rare cause of deep vein thrombosis in a young patient. Case Reports in Medicine. 2011;2011:1-5. doi:10.1155/2011/123041
11. Cinà CS, Riccioli V, Passanisi G, Musumeci G, Loreto C, Castorina S. Computerized tomography and 3-D rendering help to select surgical strategy in leiomyosarcoma of the inferior vena cava. Updates in Surgery. 2013;65(4):283-288. doi:10.1007/s13304-013-0225-0
12. Rusu CB, Gorbatâi L, Szatmari L, Koren R, Bungărdean CI, Feciche BO, Bumbuluţ C, Andraş IM, Rahotă R, Telecan T, Coman I, Rath-Wolfson L, Crişan N. Leiomyosarcoma of the inferior vena cava. Our experience and a review of the literature. Rom J Morphol Embryol. 2020;61(1):227-233. doi: 10.47162/RJME.61.1.25. PMID: 32747914; PMCID: PMC7728114.
13. Mastoraki A, Leotsakos G, Mastoraki S, et al. Challenging diagnostic and therapeutic modalities for leiomyosarcoma of inferior vena cava. International Journal of Surgery. 2015;13:92-95. doi:10.1016/j.ijsu.2014.11.051
14. Wachtel H, Gupta M, Bartlett EK, et al. Outcomes after resection of leiomyosarcomas of the inferior vena cava: A pooled data analysis of 377 cases. Surgical Oncology. 2015;24(1):21-27. doi:10.1016/j.suronc.2014.10.007
15. Mangla A, Yadav U. Leiomyosarcoma. National Center for Biotechnology Information. November 30, 2022. Accessed June 16, 2023. https://pubmed.ncbi.nlm.nih.gov/31869131/.
16. Italiano A, Toulmonde M, Stoeckle E, et al. Clinical outcome of leiomyosarcomas of vascular origin: Comparison with leiomyosarcomas of other origin. Annals of Oncology. 2010;21 (9):1915-1921. doi:10.1093/annonc/mdq039
17. Teixeira FJ, do Couto Netto SD, Perina AL, et al. Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncology Letters. 2017;14(4):3909-3916. doi:10.3892/ol.2017.6706