Contemporary Anesthesia Perspectives for Ophthalmic Surgery: A Brief Review

Main Article Content

Howard D Palte Neil H Masters

Abstract

In recent decades there have been few changes in the anesthesia management of eye surgery. By contrast, the 21st Century has witnessed major advancements in ophthalmic surgery with the adoption of minimally-invasive techniques, technologic innovations, and an expanding population seeking eye care. These  factors have impacted intraoperative exposure such that many procedures are now performed on more complex patients, and completed in quicker time. Furthermore, in pursuit of economic savings and patient satisfaction there is a trend to divert eye surgeries away from the in-hospital setting to ambulatory centers or office locations. From an anesthesia perspective, these changes have imposed a demand on providers to shorten operating room turnover times and accelerate patient discharge while maintaining high standards of patient safety. This review will address five new avenues of anesthesia care, each of which offer possibilities in accommodating facets of this new order surgical experience.  First, remimazolam is an ultra-short acting benzodiazepine that produces a predictable period of hypnosis and rapid, full recovery of consciousness because of its short context-sensitive half-time and inactive metabolites. A single 3-5 mg dose produces 11-15 minutes sleep that may be ideal for brief ocular interventions. Second, nasal CPAP/BiPAP and high flow nasal oxygen devices expand the profile of patients appropriately managed at an ambulatory center. Since their application improves arterial oxygenation and delays the onset of apneic hypoxemia, they are advantageous for patients afflicted by morbid obesity or severe obstructive sleep apnea. Third, open globe injuries have traditionally been managed under general anesthesia. However, recent studies attest to regional anesthesia as a viable alternative for many ocular insults, particularly for the elderly and patients with major organ dysfunction or risk for pulmonary aspiration. Fourth, the sub-Tenon block is a cannula-based regional ophthalmic skill performed predeominantly by ophthalmic surgeons because it necessitates conjunctival incision and dissection. Recently described variations of an incision-free, easily mastered sub-Tenon approach are likely to be included in residency and fellowship instruction, and so become an invaluable component of the anesthesiology armamentarium. This review concludes with a concise overview of the a2 agonist dexmedetomidine with the focus directed on its uses as an adjunct for adult sedation, and advantage in children for premedication and control of emergence delirium.

Article Details

How to Cite
PALTE, Howard D; MASTERS, Neil H. Contemporary Anesthesia Perspectives for Ophthalmic Surgery: A Brief Review. Medical Research Archives, [S.l.], v. 11, n. 8, aug. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4244>. Date accessed: 13 may 2024. doi: https://doi.org/10.18103/mra.v11i8.4244.
Section
Review Articles

References

1. Brohan J, Goudra BG. The role of GABA receptor agonists in anesthesia and sedation. CNS Drugs. 2017;31:845-6.
2. Colao J, Correa DR. Rapidly metabolized anesthetics: novel alternative agents for procedural sedation. J Anesth Clin Res. 2016;7:1000690.
3. Lee A, Shirley M. Remimazolam: A review in procedural sedation. Drugs. 2021;81:1193-1201.
4. Acacia Pharma Inc. BYFAVOTM (remimazolam): US prescribing information. 2021.https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212295s000lbl.pdf. Accessed June 2023
5. Kilpatrick GJ, McIntyre MS, Cox RF, et al. CNS 7056: a novel ultra-short-acting benzodiazepine. Anesthesiology. 2007;107:60-6.
6. Rex DK, Bhandari R, Lorch DG et al. Safety and efficacy of remimazolam in high risk colonoscopy: a randomized trial. Dig Liver Dis. 2021;53:94-101.
7. Pastis NJ, Yarmus LB, Schippers F, et al. Safety and efficacy of remimazolam compared with placebo and midazolam for moderate sedation during bronchoscopy. Chest. 2019;155:137-46.
8. Sneyd JR, Gambus PL, Rigby-Jones AE. Current status of perioperative hypnotics, role of benzodiazepines, and the case for remimazolam: a narrative review. BJA. 2021;127:41-55.
9. US Food and Drug Administartion. 212295Orig1s000 clinical review(s) 2020. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/212295Orig1s000MedR.pdf. Accessed June 2023.
10. Chen W, Chen S, Huang Y. Induction and maintenance of procedural sedation in adults: focus on remimazolam injection. Expert Review of Clinical Pharmacology. 2021;14:411-26.
11. Négrel AD, Thylefors B. The global impact of eye injuries. Ophthalmic Epidemiol. 1998;5:143–169.
12. Kuhn F, Morris R, Witherspoon CD, et al. The Birmingham Eye Trauma Terminology system (BETT). Journal Français d’Ophtalmologie. 2004;27(2):206–210.
13. Miller SC, Fliotsos MJ, Justin GA, et al. Global current practice patterns for the management of open globe injuries. Am J Ophthalmol. 2022;234:259-273.
14. Palte HD. Ophthalmic regional blocks: management, challenges, and solutions. Local Reg Anesth. 2015;8:57–70
15. Scott IU, MCCabe CM, Flynn HW, et al. Local anesthesia with intravenous sedation for surgical repair of selected open globe injuries. Am J Ophthalmol 2002;134:707-11.
16. Scott IU, Gayer S, Voo I, et al. Regional anesthesia with monitored anesthesia care for surgical repair of selected open globe injuries. Ophthalmic Surgery, Laser & Imaging. 2005;36:122-8.
17. McClellan AJ, Daubert JJ, Relhan N, et al. Comparison of regional vs. general anesthesia for surgical repair of open-globe injuries at a university referral center. Ophthalmology retina. 2017;1:188-91.
18. Fan J, Hudson JL, Fan KC, et al. Evolving use of regional vs. general anesthesia for the surgical repair of opennglobe injuries. Am J Ophthalmol 2023;251:71-6.
19. American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: an updated report. Anesthesiology. 2014;120:268-86.
20. Marull J, Vachon MJ, Buitran D, et al. Use of CPAP machines in the perioperative setting in ambulatory surgical centers. Nature and Science of Sleep. 13, 2137-2140.
21. Ashraf-Kashani, N, Kumar R. High-flow nasal oxygen therapy. BJA Education Volume 17, Issue 2, February 2017, Pages 57–62,
22. Spence EA, Rajaleelan W, Wong J, et al. The Effectiveness of High-Flow Nasal Oxygen During the Intraoperative Period: A Systematic Review and Meta-analysis. Anesth Analg. 2020 Oct;131:1102-1110.
23. Wong DT, Dallaire A, Singh KP, et al. High-Flow Nasal Oxygen Improves Safe Apnea Time in Morbidly Obese Patients Undergoing General Anesthesia: A Randomized Controlled Trial. Anesth Analg. 2019 Oct;129:1130-1136.
24. Roy A, Khanna P, Chowdhury SR, et al. The Impact of High-flow Nasal Cannula vs Other Oxygen Delivery Devices during Bronchoscopy under Sedation: A Systematic Review and Meta-analyses. Indian J Crit Care Med. 2022 Oct;26:1131-1140.
25. Lin Y, Zhang X, Li L, et al. High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial. Gastrointest Endosc. 2019 Oct;90:591-601.
26. Zhang W, Yin H, Xu Y, et al. The effect of varying inhaled oxygen concentrations of high-flow nasal cannula oxygen therapy during gastroscopy with propofol sedation in elderly patients: a randomized controlled study. BMC Anesthesiol. 2022 Nov 2;22:335.
27. Vijitpavan A, Kooncharoensuk Y. High flow versus conventional nasal cannula for oxygenation and ventilation maintenance during surgery with intravenous deep sedation by propofol: a randomized controlled study. BMC Anesthesiol. 2021 Sep 4;21:214.
28. Courbon C. Spontaneous Ventilation With High-Flow Nasal Oxygen for Elective Suspension Microlaryngoscopy. OTO Open. 2023 May 20;7:e54
29. Hermez LA, Spence CJ, Payton MJ, et al. A physiological study to determine the mechanism of carbon dioxide clearance during apnea when using transnasal humidified rapid insufflation ventilatory exchange (THRIVE). Anaesthesia. 2019 Apr;74:441-449.
30. Patel A, Nouraei SA. Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): a physiological method of increasing apnoea time in patients with difficult airways. Anaesthesia. 2015 Mar;70:323-9.
31. Turnbull CS. The hydrochlorate of cocaine: a judicious opinion of its merits. Med Surg Rep 1884;29:628-9.
32. Atkinson WS. Retrobulbar injection of anesthetic within the muscular cone. Arch Ophthalmol 1936;16:494-503.
33. Stevens JD. Curved, sub-Tenon cannula for local anesthesia. Ophthalmic Surg 1993;24:121-2.
34. Oshika T, Amano S, Araie M, et al. Current trends in cataract and refractive surgery in Japan: 1999 survey. Jpn J Ophthalmol 2001;45:383-7.
35. Tam YS, Kumar CM, Au Eong KG, et al. Trends in cataract surgery technique and anaesthesia preferences in Singapore: a 2016 survey. Ann Acad Med Singap 2018;47:390-3.
36. El-Hindy N, Johnston RL, Jaycock P, et al. The Cataract National dataset electronic multi-centre audit of 55 567 operations: anaesthetic techniques and complications. Eye 2009;23:50-5.
37. Clarke JP, Robertson G, Plummer J. Sub-Tenon block: a learning curve of 100 cases. Anaesthesia and Intensive Care 2006;34:450-2.
38. Allman KG, Theron AD, Byles DB. A new technique of incisionless minimally invasive sub-tenon’s anaesthesia. Anaesthesia 2008;63:782-3.
39. Aydin ON, Eylgor M, Aydin N. Antimicrobial activity of ropivacaine and other local anaesthetics. Eur J Anaesthesiol 2001;18:687-94.
40. Kumar CM, Seet E. Effective and cost-saving incisionless sub-Tenon’s block. Indian J Anaesth 2017;61:84-5.
41. Palte HD, Gayer S. Novel technique for minimally invasive sub-Tenon’s anesthesia. Reg Anesth Pain Med 2019;44:131-2.
42. Chua A, Chua MJ, Kumar CM. Punctal dilator facilitates insertion of blunt cannula during sub-Tenon’s block. Anaesth Intensive Care 2018;46:209-19.
43. Kilic Y, Gursoy HH, Bilgec MD, et al. Our first experiences of incisionless sub-Tenon’s block for cataract and vitroretinal surgery. Journal of Anesthesia 2023 Special Issue; 31:266.
44. Weerink MAS, Struys MMRF, Hannivoort LN, et al. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet. 2017 Aug;56:893-913.
45. Naaz S, Ozair E. Dexmedetomidine in current anaesthesia practice- a review. J Clin Diagn Res. 2014 Oct;8:GE01-4.
46. Jones JH, Aldwinckle R. Perioperative Dexmedetomidine for outpatient cataract surgery: a systematic review. BMC Anesthesiol. 2020 Apr 4;20:75.
47. Senthil S, Burugupally K, Rout U, et al. Effect of Intravenous Dexmedetomidine on Intraocular Pressure in Patients Undergoing Glaucoma Surgery Under Local Anesthesia: A Pilot Study. J Glaucoma. 2020 Oct;29:846-850
48. Ali H, Eissa S, Magdy H, et al. Dexmedetomidine as an Additive to Local Anesthesia for Decreasing Intraocular Pressure in Glaucoma Surgery: A Randomized Trial. Anesth Pain Med. 2020 Jun 27;10:e100673.
49. Pegu J, Purang AK, Dubey S, et al. Effect of dexmedetomidine on intraocular pressure as an additive in peribulbar block during glaucoma surgery. Indian J Ophthalmol. 2021 Mar;69:612-616.
50. Moore AD, Anghelescu DL. Emergence Delirium in Pediatric Anesthesia. Paediatr Drugs. 2017 Feb;19:11-20.
51. Manning AN, Bezzo LK, Hobson JK, et al. Dexmedetomidine Dosing to Prevent Pediatric Emergence Delirium. AANA J. 2020 Oct;88:359-364.
52. Ghai B, Jain D, Coutinho P, et al. Effect of low dose dexmedetomidine on emergence delirium and recovery profile following sevoflurane induction in pediatric cataract surgeries. J Anesth. 2015
53. Kim J, Kim SY, Lee JH, et al. Low-dose dexmedetomidine reduces emergence agitation after desflurane anaesthesia in children undergoing strabismus surgery. Yonsei Med J. 2014 Mar;55:508-16.
54. Lewis J, Bailey CR. Intranasal dexmedetomidine for sedation in children; a review. J Perioper Pract. 2020 Jun;30:170-175.
55. Shen F, Zhang Q, Xu Y, et al. Effect of Intranasal Dexmedetomidine or Midazolam for Premedication on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial. JAMA Netw Open. 2022 Aug 1;5:e2225473.