Cerebrolysin Improves Motor Abilities and Reverses the Long-Term Memory Acquisition Deficit in Rats with Hypoxic-Ischemic Encephalopathy

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Ericka Barrientos-Zavalza, MSc Celia Piña-Leyva, Dr Manuel Lara-Lozano, Dr Gonzalo Flores, Dr Daniel Martínez-Fong, Dr Bertha Alicia León-Chávez, Dr Anabel Jiménez-Anguiano, Dr Juan Antonio Gonzalez-Barrios


Background: Hypoxic-ischemic encephalopathy (HIE) is a neurological condition that leads to motor disabilities and even death in neonates. Unfortunately, few therapeutic alternatives can contribute to brain recovery after HIE damage. Cerebrolysin is a neuropeptide mixture that exerts neuroprotective and neurotrophic effects on injured brain tissue after systemic administration.

Aims: This study evaluated the short- and long-term beneficial effects of Cerebrolysin administration in a rat model of HIE.

Methods: Neonatal 7-day-old rats were subjected to hypoxia-ischemia injury and then intraperitoneally administered Cerebrolysin (10 mL/kg of body weight) once a day for 7 days, from postnatal days 8 to 14. Growth development, blood-brain barrier permeability, and neurobehavioral tests were performed.

Results: Cerebrolysin administration after hypoxic-ischemic insult minimized brain damage, edema and increased cellular viability. Furthermore, this neuroprotective effect improves some motor abnormalities and, during adulthood, reverses the long-term memory acquisition deficit caused by HIE.

Conclusion: Repeated Cerebrolysin administration can safely and effectively reduce HIE motor disabilities and reverse long-term memory acquisition deficits in neonatal rats.

Keywords: Neuroprotection, novel object recognition, learning and memory, neonatal brain injury, Cerebrolysin

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How to Cite
BARRIENTOS-ZAVALZA, Ericka et al. Cerebrolysin Improves Motor Abilities and Reverses the Long-Term Memory Acquisition Deficit in Rats with Hypoxic-Ischemic Encephalopathy. Medical Research Archives, [S.l.], v. 11, n. 8, aug. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4345>. Date accessed: 02 oct. 2023. doi: https://doi.org/10.18103/mra.v11i8.4345.
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