Medical use of hydrolyzed collagen in osteoporosis
Main Article Content
Abstract
In this narrative review, the scientific background of the use of collagen in osteoporosis is presented, drawing inspiration for a discussion on the food supplements use in medicine. The first part of the paper provides an overview on collagen and hydrolyzed collagen. The second part deals with collagen carential disease, comprising conditions ranging from nail fragility to osteoporosis. The third part focuses on osteoporosis and its treatment, the fourth on hydrolyzed collagen. The medical use of hydrolyzed collagen provides a typical example of “Green economy”, the new alliance between man and nature that is involving medicine too.
Keywords:
Collagen, Hydrolized collagen, Collagen carential disease,, Osteoporosis, Green medicine
Article Details
How to Cite
SILVESTRINI, Bruno; SILVESTRINI, Mauro.
Medical use of hydrolyzed collagen in osteoporosis.
Medical Research Archives, [S.l.], v. 11, n. 9, sep. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/4358>. Date accessed: 28 apr. 2024.
doi: https://doi.org/10.18103/mra.v11i9.4358.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Rennie M. Teasing out the truth about collagen. J. Physiol. 1999; 521 (Pt 1):1.
2. Di Lullo G A, Sweeney S M, Korkko J, Ala-Kokko L, San Antonio J D: Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002; 277(6):4223-4231.
3. Silvestrini B, Innocenti M, Perrotta A M, Cheng C Y. Physiopathology and treatment of collagen carential disease. Minerva Medica. 2019; 112(3):403-404.
4. Guyton AC. Medical Physiology, Saunders, Philadelphia, 1986.
5. Stuart JM, Townes AS, Kang AH. Collagen autoimmune arthritis. Annu Rev Immunol. 1984;2:199-218.
6. Robbins, Cotran. Pathologic Basis of Disease. 9th ed, Philadelphia, Saunders, 2015.
7. Silvestrini B, Silvestrini M. Medical Implications of the Relationships among Protein Denaturation, Necrosis and Inflammation: An Intriguing Story [Internet]. Tendons - Trauma, Inflammation, Degeneration, and Treatment. IntechOpen. 2023. http://dx.doi.org/105772/intechopen.108018).
8. Silvestrini B, Kirschner G. Integratori alimentari e dietetici contenenti gelatina idrolizzata e loro uso in campo medico-sanitario. Patent n. IT 1299131, 1998.
9. Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, Burckhardt P, Cooper C, Christiansen C, Cummings S, Eisman JA, Fujiwara S, Glüer C, Goltzman D, Hans D, Krieg MA, La Croix A, McCloskey E, Mellstrom D, Melton LJ 3rd, Pols H, Reeve J, Sanders K, Schott AM, Silman A, Torgerson D, van Staa T, Watts NB, Yoshimura N. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18(8):1033-1046.
10. Scala J, Hollies NRS, Sucher KP. Effect of daily gelatin ingestion on human scalp hair. Nutrition Reports International. 1976; 13(6): 579-592.
11. Silvestrini B. Method for increasing hair growth. Patent US N. 4,749,684,1988
12. Silvestrini B, Yan Cheng C, Innocenti M. Collagen Involvement in Health, Disease, and Medicine. Collagen Biomaterials. IntechOpen; 2022. http://dx.doi.org/10.5772/intechopen.101978
13. Silvestrini B. La cosmesi moderna: da arte della bellezza a scienza medica. HPC1_it. ; 2021.
14. Silvestrini B, Silvestri R, Cheng CY, Ceracchi M, Innocenti M. A method to measure the barrier effect of drug and its application in the study of hydrolyzed collagen. Agro Food Industry Hi Tech; 2021.
15. Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants (Basel). 2020; 22; 9(2):181.
16. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA. 1978; 5(2):871-875.
17. Council of Europe. Homeostasis, a model to distinguish between foods (including food supplement) and medicinal products. Public Health Committee (partial agreement) (P-SP-Nu-FS). (07.02.2008).
18. Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd SK. Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight. Sci Rep. 2022 Jun 30; 12(1):9446.
19. Policar M, Silvestrini B. Preparation pour le trattement de l’osteoporose et pur favoriser la reparation des frattures osseuses. Fr2764191 (A1) 1998-12-11.
20. Nomura Y, Oohashi K, Watanabe M, Kasugai S. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. 2005; 21(11-12):1120-1126.
21. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem. 2010; 58(2):835-41.
22. de Almeida Jackix E, Cúneo F, Amaya-Farfan J, de Assunção JV, Quintaes KD. A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. J Med Food. 2010; 13(6):1385-1390.
23. Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010; 46(3):827-834.
24. Guillerminet F, Fabien-Soulé V, Even PC, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporos Int. 2012; 23(7): 1909-1919.
25. Parfitt AM, Simon LS, Villanueva AR, Krane SM. Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Min Res 1987; 2(5):427-36.
26. Hassager C, Jensen LT, Johansen JS, Riis BJ, Melkko J, Pødenphant J, Risteli L, Christiansen C, Risteli J. The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism. 1991; 40(2):205-208.
27. König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018; 10(1):97.
28. Zdzieblik D, Oesser S, König D. Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women. J Bone Metab. 2021; 28(3):207-213.
29. Shuster S. Osteoporosis, like skin ageing, is caused by collagen loss which is reversible. J R Soc Med. 2020; 113(4):158-160.
30. Shuster S. Osteoporosis, a unitary hypothesis of collagen loss in skin and bone. Med Hypotheses. 2005; 65(3):426-432.
31. Silvestrini B. Il farmaco green. 2023, in press.
2. Di Lullo G A, Sweeney S M, Korkko J, Ala-Kokko L, San Antonio J D: Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002; 277(6):4223-4231.
3. Silvestrini B, Innocenti M, Perrotta A M, Cheng C Y. Physiopathology and treatment of collagen carential disease. Minerva Medica. 2019; 112(3):403-404.
4. Guyton AC. Medical Physiology, Saunders, Philadelphia, 1986.
5. Stuart JM, Townes AS, Kang AH. Collagen autoimmune arthritis. Annu Rev Immunol. 1984;2:199-218.
6. Robbins, Cotran. Pathologic Basis of Disease. 9th ed, Philadelphia, Saunders, 2015.
7. Silvestrini B, Silvestrini M. Medical Implications of the Relationships among Protein Denaturation, Necrosis and Inflammation: An Intriguing Story [Internet]. Tendons - Trauma, Inflammation, Degeneration, and Treatment. IntechOpen. 2023. http://dx.doi.org/105772/intechopen.108018).
8. Silvestrini B, Kirschner G. Integratori alimentari e dietetici contenenti gelatina idrolizzata e loro uso in campo medico-sanitario. Patent n. IT 1299131, 1998.
9. Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, Burckhardt P, Cooper C, Christiansen C, Cummings S, Eisman JA, Fujiwara S, Glüer C, Goltzman D, Hans D, Krieg MA, La Croix A, McCloskey E, Mellstrom D, Melton LJ 3rd, Pols H, Reeve J, Sanders K, Schott AM, Silman A, Torgerson D, van Staa T, Watts NB, Yoshimura N. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18(8):1033-1046.
10. Scala J, Hollies NRS, Sucher KP. Effect of daily gelatin ingestion on human scalp hair. Nutrition Reports International. 1976; 13(6): 579-592.
11. Silvestrini B. Method for increasing hair growth. Patent US N. 4,749,684,1988
12. Silvestrini B, Yan Cheng C, Innocenti M. Collagen Involvement in Health, Disease, and Medicine. Collagen Biomaterials. IntechOpen; 2022. http://dx.doi.org/10.5772/intechopen.101978
13. Silvestrini B. La cosmesi moderna: da arte della bellezza a scienza medica. HPC1_it. ; 2021.
14. Silvestrini B, Silvestri R, Cheng CY, Ceracchi M, Innocenti M. A method to measure the barrier effect of drug and its application in the study of hydrolyzed collagen. Agro Food Industry Hi Tech; 2021.
15. Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants (Basel). 2020; 22; 9(2):181.
16. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA. 1978; 5(2):871-875.
17. Council of Europe. Homeostasis, a model to distinguish between foods (including food supplement) and medicinal products. Public Health Committee (partial agreement) (P-SP-Nu-FS). (07.02.2008).
18. Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd SK. Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight. Sci Rep. 2022 Jun 30; 12(1):9446.
19. Policar M, Silvestrini B. Preparation pour le trattement de l’osteoporose et pur favoriser la reparation des frattures osseuses. Fr2764191 (A1) 1998-12-11.
20. Nomura Y, Oohashi K, Watanabe M, Kasugai S. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. 2005; 21(11-12):1120-1126.
21. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem. 2010; 58(2):835-41.
22. de Almeida Jackix E, Cúneo F, Amaya-Farfan J, de Assunção JV, Quintaes KD. A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. J Med Food. 2010; 13(6):1385-1390.
23. Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010; 46(3):827-834.
24. Guillerminet F, Fabien-Soulé V, Even PC, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporos Int. 2012; 23(7): 1909-1919.
25. Parfitt AM, Simon LS, Villanueva AR, Krane SM. Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Min Res 1987; 2(5):427-36.
26. Hassager C, Jensen LT, Johansen JS, Riis BJ, Melkko J, Pødenphant J, Risteli L, Christiansen C, Risteli J. The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism. 1991; 40(2):205-208.
27. König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018; 10(1):97.
28. Zdzieblik D, Oesser S, König D. Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women. J Bone Metab. 2021; 28(3):207-213.
29. Shuster S. Osteoporosis, like skin ageing, is caused by collagen loss which is reversible. J R Soc Med. 2020; 113(4):158-160.
30. Shuster S. Osteoporosis, a unitary hypothesis of collagen loss in skin and bone. Med Hypotheses. 2005; 65(3):426-432.
31. Silvestrini B. Il farmaco green. 2023, in press.