Multimodal cancer treatment and its association with nutrition care practices in patients with head and neck and esophageal cancer: an international prospective cohort study

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Published Nov 29, 2023
DOI: https://doi.org/10.18103/mra.v11i11.4591

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Main Article Content

Leah Gramlich
Department of Medicine, University of Alberta, Canada
Rupinder Dhaliwal
Canadian Nutrition Society, Ottawa, ON K1C 6A8, Canada
Narisorn Lakananurak
Division of Clinical Nutrition, Department of Medicine, Chulalongkorn University, Bangkok, Thailand, 10300
Vickie Baracos
Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G1Z2, Canada
Merran Findlay
Cancer Services, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia; Chris O’Brien Lifehouse, Camperdown, NSW 2050, Australia; Cancer Care Research Unit, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050 Australia; Maridulu Budyari Gumal (SPHERE) Cancer Clinical Academic Group, South Western Sydney Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
http://orcid.org/0000-0001-6964-1533 Judith D. Bauer
Department of Nutrition, Dietetics and Food, Monash University, Clayton, Victoria, Australia
http://orcid.org/0000-0002-3830-5147 Marian de van der Schueren
Department of Nutrition, Dietetics and Lifestyle, School of Allied Health, HAN University of Applied Sciences, 6503 GL Nijmegen, The Netherlands; Department of Human Nutrition and Health, Wageningen University and Research, 6700 AA Wageningen, The Netherlands
Alessandro Laviano
Department of Translational and Precision Medicine, Sapienza University of Rome, I-00185 Rome, Italy
Adrianne Wideman
Department of Nutrition, Food Science and Packaging, San Jose State University, San Jose, CA 95192, USA; University of California Davis Medical Center, Sacramento, CA 94558-5004, USA
Andrew G. Day
Department of Public Health Sciences, Queens’ University, Kingston Ontario, Canada
Lisa Martin
Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.

Abstract

Background: Both cancer and its’ treatment contribute to the development of malnutrition, particularly in cancers that impact nutrition intake such as head and neck (HNC) and esophageal (EC) cancers. This study was undertaken to explore the relationship between cancer treatment and nutrition care in patients with HNC and EC.


Methods: Adult patients (≥18 years) with newly diagnosed head and neck (HN) or esophageal (ESO) cancers scheduled to receive cancer treatment were enrolled between 2016 and 2018 in the INFORM study, a longitudinal multi-centre prospective cohort study. Baseline clinical characteristics of patients, cancer characteristics, treatment type (chemotherapy/radiotherap y /surgery) and frequency, nutrition risk (Patient Generated Subjective Global Assessment Short Form (PG-SGA SF) and nutrition care were recorded.


Results: 100 HNC and 51 EC patients were included. Data were collected across 4 time periods from baseline to 6 months at 11 sites in Canada, Australia Italy, The Netherlands and the United States. Seventy-nine percent of the patients were male with a mean (SD) age of 63 (10) years. At admission, the mean (SD) BMI was 27 (5) kg/m2 and 30% were current smokers. Baseline PGA-SGA SF was ≥ 4 indicating nutrition risk for 59% of the HNC and 77% of the EC patients. The number of cancer treatments was positively associated with increases in enteral (EN) and parenteral nutrition (PN). In HNC patients receiving a single cancer treatment, 39% required EN and with 3 cancer treatment types, 78% required EN. In EC requiring a single cancer treatment, 50% required EN and in patients with 3 cancer treatments 94% required EN.


Conclusion: The number of cancer treatment modalities is associated with the intensity of nutrition therapy required to sustain the patients through their cancer journey.

Keywords: nutrition care, head and neck cancer, esophageal cancer, cancer treatment

Article Details

How to Cite
GRAMLICH, Leah et al. Multimodal cancer treatment and its association with nutrition care practices in patients with head and neck and esophageal cancer: an international prospective cohort study. Medical Research Archives, [S.l.], v. 11, n. 11, nov. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4591>. Date accessed: 16 may 2024. doi: https://doi.org/10.18103/mra.v11i11.4591.
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Issue
Vol 11 No 11 (2023): November Issue, Vol.11, Issue 11
Section
Research Articles

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