Doctors Diagnosing Addiction – Are the Blind Leading the Blind?

Main Article Content

Richard A Lawhern, PhD

Abstract

This paper addresses the questions, “are clinicians who treat patients in pain – or even specialists in addiction medicine -- appropriately prepared to accurately diagnose opioid use disorder? Further, is prevailing public policy on pain management employing opioid analgesics firmly grounded in science?” The author summarizes key findings from reviews of pertinent medical literature on pain treatment and diagnosis of substance use disorder.


 Medical doctors are widely understood to be inadequately trained in diagnosis of both pain and addiction among their patients.


 There is currently no consensus standard of practice to guide clinicians in either prescription of opioids or diagnosis of “substance use disorder” among patients treated for pain.  Available medical literature and clinical experience do not support the thesis that clinicians prescribing in a continuing relationship with pain patients have contributed measurably to the widely discussed US “opioid crisis”


.  General principles on the management of pain and the diagnosis of substance use disorder do exist but are not widely understood by practicing clinicians. Entry of a “substance use disorder” or “addiction” code in patient electronic medical records can be a literal “kiss of death” for ongoing treatment of severe pain. Thus it seems necessary to caution clinicians who treat pain - and policy makers who oversee them - that much of what they think they “know” about substance use disorder and its causes may no longer be current or may have been wrong in the first place.

Keywords: Diagnosing Addiction, Doctors Diagnosing Addiction

Article Details

How to Cite
LAWHERN, Richard A. Doctors Diagnosing Addiction – Are the Blind Leading the Blind?. Medical Research Archives, [S.l.], v. 11, n. 11, nov. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4726>. Date accessed: 16 may 2024. doi: https://doi.org/10.18103/mra.v11i11.4726.
Section
Research Articles

References

1. Aubry L and Carr BT, “Overdose, opioid treatment admissions and prescription opioid pain reliever relationships: United States, 2010–2019” , Frontiers in Pain Medicine, August 4, 2022,
https://www.frontiersin.org/articles/10.3389/fpain.2022.884674/full

2. Singer JA, Sullum JZ, Schatman ME. “Today’s nonmedical opioid users are not yesterday’s patients; implications of data indicating stable rates of nonmedical use and pain reliever use disorder.” J Pain Res. 2019;12:617-620 https://doi.org/10.2147/JPR.S199750

3. Richard A Lawhern PhD, “Doctors Prescribing To Their Patients Did Not Cause the US Opioid Crisis” American Council on Science and Health, January 9, 2023, https://www.acsh.org/news/2023/01/09/doctors-prescribing-their-patients-did-not-create-us-opioid-crisis-16787

4. Jalal H, Buchanach JM, Roberts MS, Balmert L, Zhang L, and Burke DS, “Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016” Science,Vol 361, Issue 6408, 21 September 2018, https://www.science.org/doi/10.1126/science.aau1184

5. Volkow N and McMillan AT, “Opioid Abuse in Chronic Pain -- Misconceptions and Mitigation Strategies, ” New England Journal of Medicine, March 31, 2016, http://www.nejm.org/doi/full/10.1056/NEJMra1507771

6. Dydyk AM, Sizemore DC, Haddad LM, Lindsay L, Porter BR, NP Safe Prescribing of Controlled Substances While Avoiding Drug Diversion January 29, 2023, https://www.ncbi.nlm.nih.gov/books/NBK564518/

7. Gudin J, Fudin J. “Best Practices Are Still Largely Undefined in Task Force Report.” Pract Pain Manag. 2019; 19(4). https://www.practicalpainmanagement.com/resources/clinical-practice-guidelines/best-practices-are-still-largely-undefined-task-force-report

8. Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. “CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022.” MMW Recomm Rep 2022; 71(No. RR-3):1–95.

9. Martin SA, Poteet RA, and Lazris A, “Neat, Plausible, and Generally Wrong: A Response to the CDC Recommendations for Chronic Opioid Use” Medium, September 7, 2016, https://medium.com/@stmartin/neat-plausible-and-generally-wrong-a-response-to-the-cdc-recommendations-for-chronic-opioid-use-5c9d9d319f71#.wzchd1kkl

10. Beletsky, L and Nicholson KM “CDC's Updated Opioid Guidelines Are Necessary, but Not Sufficient” Medpage Today, November 18, 2022, https://www.medpagetoday.com/opinion/second-opinions/101825

11. Ghey N “The Other Opioid Crisis: How False Narratives Are Hurting Patients”, Discourse, July 18, 2022. https://www.discoursemagazine.com/culture-and-society/2022/07/18/how-false-narratives-about-opioids-are-hurting-patients/

12. Satel S, “The Myth of What’s Driving The Opioid Crisis,” Politico Magazine, February 21, 2018, https://www.politico.com/magazine/story/2018/02/21/the-myth-of-the-roots-of-the-opioid-crisis-217034/

13. Lawhern RA, “We Need New Laws To Protect People in Pain - The CDC’s revised prescribing guidelines retain an anti-opioid bias and do nothing to reverse the harmful policies inspired by the 2016 version.” Reason Magazine, February 14, 2023, https://reason.com/2023/02/14/we-need-new-laws-to-protect-people-in-pain/

14. Darnall BD, Juurlink D, et al, “International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering,” Pain Medicine, Volume 20, Issue 3, March 2019, Pages 429–433, https://doi.org/10.1093/pm/pny228

15. Dowell D, Haegerich T and Chou R “No Shortcuts to Safer Opioid Prescribing”, New England Journal of Medicine, June 13, 2019, https://www.nejm.org/doi/full/10.1056/NEJMp1904190

16. Centers for Disease Control and Prevention, “CDC Advises Against Misapplication of the Guideline for Prescribing Opioids for Chronic Pain,” April 24, 2019, https://www.cdc.gov/media/releases/2019/s0424-advises-misapplication-guideline-prescribing-opioids.html

17. Maia Szalzvitz, “Opioid Addiction Is a Huge Problem, but Pain Prescriptions Are Not the Cause -- Cracking down on highly effective pain medications will make patients suffer for no good reason” Scientific American, May 2016, https://blogs.scientificamerican.com/mind-guest-blog/opioid-addiction-is-a-huge-problem-but-pain-prescriptions-are-not-the-cause/

18. Nita Ghey, “The Other Opioid Crisis: How False Narratives Are Hurting Patients”, Discourse, July 18, 2022. https://www.discoursemagazine.com/culture-and-society/2022/07/18/how-false-narratives-about-opioids-are-hurting-patients/

19. Jacob Sullum, “Opioid Epidemic Myths” Reason Magazine, May 18, 2016, https://reason.com/2016/05/18/opioid-epidemic-myths/

20. Miranda Hitti, “Prescription Painkiller Addiction: 7 Myths”, WebMD, August 10, 2011, https://www.webmd.com/pain-management/features/prescription-painkiller-addiction-7-myths#5

21. Sally Satel, “The Myth of What’s Driving The Opioid Crisis” Politico Magazine, February 21, 2018, https://www.politico.com/magazine/story/2018/02/21/the-myth-of-the-roots-of-the-opioid-crisis-217034/

22. Stanton Peele, PhD, “Overdose and Other Drug and Addiction Myths -- Everything you believe about drugs/addiction is wrong. EVERYTHING. It matters.” Psychology Today, January 20, 2018. https://www.psychologytoday.com/us/blog/addiction-in-society/201801/overdose-and-other-drug-and-addiction-myths

23. American Academy of Family Physicians, “Frontline Physicians Call on Politicians to End Political Interference in the Delivery of Evidence Based Medicine”, May 15, 2019 https://www.aafp.org/news/media-center/more-statements/physicians-call-on-politicians-to-end-political-interference-in-the-delivery-of-evidence-based-medicine.html

24. American Medical Association, “AMA urges CDC to revise opioid prescribing guideline” June 18, 2020, https://www.ama-assn.org/press-center/press-releases/ama-urges-cdc-revise-opioid-prescribing-guideline

25. Madera JL, “RE Proposed 2022 CDC Clinical Practice Guideline for Prescribing Opioids (Docket No. CDC-2022-0024”, American Medical Association, April 11, 2022, Letter to Captain Christopher M. Jones, … Acting Director National Center for Injury Prevention and Control Centers for Disease Control and Prevention. https://searchlf.ama-assn.org/letter/documentDownload?uri=%2Funstructured%2Fbinary%2Fletter%2FLETTERS%2F2022-4-11-Letter-to-Jones-re-2022-CDC-Proposed-Clinical-Guidelines-for-Prescribing-Opioids-v2.pdf

26. Lawhern RA, Rose M, Tennant F, Nadeau SE, Trescot A, Rust R, Borel H, Clement NJ, et al. Correspondence to David Meyers, Acting Director, Agency for Healthcare Research and Quality re “AHRQ Comparative Effectiveness Review 240 (Treatments for Acute Pain) Must Be Immediately Withdrawn”, January 21, 2021.

27. Lawhern RA, and Nadeau SE, “Understanding the Limitations of Non-Opioid Therapies in Chronic Pain”, invited editorial for the October 2017 print edition, in Practical Pain Management, https://www.practicalpainmanagement.com/resources/practice-management/behind-ahrq-report

28. Kollas CD, “In Bad Faith – the Influence of PROP and CDC on Failed National Opioid Policy” American Academy of Hospice and Palliative Medicine, 07/21/2022, https://learn.aahpm.org/content/bad-faith-influence-prop-and-cdc-failed-national-opioid-policy

29. Chuck Dinerstein, “The True Story of Morphine Milligram Equivalents”, American Council on Science and Health, March 1, 2022, https://www.acsh.org/news/2022/03/01/true-story-morphine-milligram-equivalents-mme-16154

30. Fudin, J, Cleary J, Pratt M and Schattman M, “The MEDD Myth: the impact of pseudoscience on pain research and prescribing guideline development” Journal of Pain Research, Vol. 9, pp 153-156, 23 March 2016, https://www.dovepress.com/the-medd-myth-the-impact-of-pseudoscience-on pain-research-and-prescri-peer-reviewed-fulltext-article-JPR

31. Darnall BD, Juurlink D, et al, “International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering,” Pain Medicine, Volume 20, Issue 3, March 2019, Pages 429–433, https://doi.org/10.1093/pm/pny228

32. Hemphill N, “Forced tapering may harm patients with chronic pain on opioids” Healio- News, Psychiatry, September 9, 2022. https://www.healio.com/news/psychiatry/20220909/forced-tapering-may-harm-patients-with-chronic-pain-on-opioids

33. Travis N Rieder “Is Non-Consensual Tapering of High Dose Opioid Therapy Justifiable?” AMA Journal of Ethics, August, 2020, https://journalofethics.ama-assn.org/article/nonconsensual-tapering-high-dose-opioid-therapy-justifiable/2020-08

34. Nadeau SE, Wu JK, and Lawhern RA, “Opioids and Chronic Pain: An Analytical Review of the Clinical Evidence” Frontiers in Pain Research, August 17, 2021, https://www.frontiersin.org/articles/10.3389/fpain.2021.721357/full

35. Deepty Agrawal, Mercy A. Udoji, Andrea Trescot, “Genetic Testing for Opioid Pain Management: A Primer” Pain Therapy, DOI 10.1007/s40122-017-0069-2 , February 5, 2017 https://pubmed.ncbi.nlm.nih.gov/28409480/

36. Carsten Skarke, “Genetic Predictors of the Clinical Response to Opioid Analgesics”, Clinical Pharmacokinetics, 2004, https://www.academia.edu/28334503/Genetic_Predictors_of_the_Clinical_Response_to_Opioid_Analgesics

37. London C, “DOJ Overreach: The Criminalization of Physicians,” Journal of Legal Medicine, 41:3-4, 191-203, DOI: 10.1080/01947648.2022.2147366 https://doi.org/10.1080/01947648.2022.2147366|

38. Jeffrey Singer and Colleen Cowles, “War on Us: How the War on Drugs and Myths about Addiction Have Created a War on All of Us”, Cato Institute Events (Interview), March 18, 2020, https://www.cato.org/events/war-us-how-war-drugs-myths-about-addiction-have-created-war-all-us

39. Alicia Agnoli, MD, MPH, MHS1,2; Guibo Xing, PhD2; Daniel J. Tancredi, PhD2,3; et al “Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioids”, JAMA. 2021; 326(5):411-419. https://jamanetwork.com/journals/jama/fullarticle/2782643

40. Jeffrey Singer and Trevor Burrus, “Cops Practicing Medicine – the Parallel Histories of Drug War I and Drug War II”, Cato Institute, November 29, 2022, https://www.cato.org/white-paper/cops-practicing-medicine#
41. Szalavitz M, “Entire Body is Shaking -- Why Americans With Chronic Pain are Dying”, New York Times Opinion, January 3, 2023, https://www.nytimes.com/2023/01/03/opinion/chronic-pain-suicides.html

42. Gavin K, “Pain Patients Who Take Opioids Can’t Get in the Door at Half of Primary Care Clinics” Michigan Medicine, January 25, 2021, https://www.michiganmedicine.org/health-lab/pain-patients-who-take-opioids-cant-get-door-half-primary-care-clinics

43. Addiction Blog, “DSM-5 Criteria for Substance Use Disorders” Gateway Foundation, June 2023, https://www.gatewayfoundation.org/addiction-blog/dsm-5-substance-use-disorder/

44. Grant, JR, and Chamberlain, RM, “Expanding the Definition of Addiction: DSM-5 vs. ICD-11” [Opinion], CNS Spectr. 2016 Aug; 21(4): 300–303. doi:10.1017/S1092852916000183

45. Francis A, “Why Did DSM 5 Botch Somatic Symptom Disorder? - A closed process, tunnel vision, and time pressure.” Psychology Today, February 6, 2013, https://www.psychologytoday.com/intl/blog/saving-normal/201302/why-did-dsm-5-botch-somatic-symptom-disorder

46. Francis A, “The new somatic symptom disorder in DSM-5 risks mislabeling many people as mentally ill,” BMJ 2013;346:f1580, https://www.bmj.com/content/346/bmj.f1580

47. Levine BE, “DSM-5: Science or Dogma? Even Some Establishment Psychiatrists Embarrassed by Newest Diagnostic Bible” Huffpost, February 11, 2013, https://www.huffpost.com/entry/dsm-5_b_2657667

48. Gaehmi SN “After the failure of DSM: clinical research on psychiatric diagnosis” World Psychiatry, 2018 Oct; 17(3): 301–302. Published online 2018 Sep 7.
doi:10.1002/wps.20563

49. Lane, C, “The NIMH Withdraws Support for DSM-5” Psychology Today, May 4, 2013. https://www.psychologytoday.com/us/blog/side-effects/201305/the-nimh-withdraws-support-dsm-5

50. American Society of Addiction Medicine,“DSM-5 Criteria for Diagnosis of Opioid Use Disorder,” 2023, https://www.asam.org/docs/default-source/education-docs/dsm-5-dx-oud-8-28-2017.pdf

51. Cunningham C, Edlund, MJ, Fishman M, et al, “The ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update” The ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update” American Society for Addiction Medicine, 2020, https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/npg-jam-supplement.pdf?sfvrsn=a00a52c2_4

52. Lawhern RA “CDC Guidelines on Prescription of Opioids – More and Less Than Meets The Eye”, Yearly conference of the Florida Society for Interventional Pain Physicians, Tampa Florida, July 29, 2022. During a brief audience Q&A session at the beginning of this session attended by just over 100 clinicians active in treating pain as a primary practice, only two responded that they were Board certified in both pain medicine and addiction medicine. Similar lack of exposure to guidelines on diagnosis of opioid use disorder was also confirmed in a recent informal poll by the author, among ~70 experienced clinicians practicing in pain or addiction.

53. Nadeau SE, Wu JK and Lawhern RA, “Opioids and Chronic Pain: An Analytic Review of the Medical Literature”, Frontiers in Pain Research, Volume 2 - 2021 | https://doi.org/10.3389/fpain.2021.721357

54. Oliva EM, Bowe T, and Tavakoli A, et al, “Development and Applications of the Veterans Health Administration’s Stratification Tool for Opioid Risk Mitigation (STORM) to Improve Opioid Safety and Prevent Overdose and Suicide” Department of Veterans Affairs, “Psychological Services”2017, Vol 14, No 1, pp 34-49. Available for purchase through American Psychological Association APA Psych Net, https://psycnet.apa.org/doiLanding?doi=10.1037%2Fser0000099

55. Bohnert ASB, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. (2011) 305:1315–21. doi: 10.1001/ jama.2011.370

56. Sun EC, Darnall BD, Baker LC, Mackey S. Incidence of and risk factors for chronic opioid use among opioid-naive patients in the postoperative period. JAMA Intern Med 2016;176:1286–93. https://doi.org/10.1001/jamainternmed.2016.3298 PMID:27400458

57. Brat GA, Agniel D, Beam A, et al. Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study. BMJ 2018;360:j5790. https://doi.org/10.1136/bmj.j5790 PMID:29343479

58. Jennifer P Schneider MD, PhD, “The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals With Chronic Non-Cancer Pain”, Practical Pain Management, https://www.practicalpainmanagement.com/painscan/abstract/role-opioid-prescription-incident-opioid-abuse-dependence-among-individuals-which

59. Mills L and Lohman D , “Not Allowed To Be Compassionate -- Chronic Pain, the Opioid Crisis, and Unintended Harms in the US”, Human Rights Watch, December 18, 2018 https://www.hrw.org/report/2018/12/18/not-allowed-be-compassionate/chronic-pain-overdose-crisis-and-unintended-harms-us#

60. Josh Bloom, PhD, “JAMA Study: Forced Opioid Tapering Harms People. Gee, What a Surprise.”, American Council On Science and Health, August 3, 2021, https://www.acsh.org/news/2021/08/03/jama-study-forced-opioid-tapering-harms-people-gee-what-surprise-15712

61. ACP Internist, “Stopping opioid treatment linked to increased risk of death from overdose or suicide in veterans,” March 17, 2022, https://acpinternist.org/weekly/archives/2020/03/17/2.htm?fbclid=IwAR0mttCKBkyx2-QOZ2u1JrCv_hHpsQ0mmhsa29-Chn1I9XvgUZftb9CgPpY

62. Lawhern RA: daily observations of ~20 online peer-to-peer patient support groups on Facebook.com, serving an aggregate of over 40,000 patients and family caregivers.

63. Grant M, “Terminally Ill Cancer Patients Denied Prescription Drugs at the Pharmacy, WESH News, Orlando Florida, https://www.wesh.com/article/terminally-ill-cancer-patients-denied-prescription-drugs-at-the-pharmacy/4440015#

64. Lawhern RA, “We Need New Laws to Protect People in Pain”, Reason Magazine, 2.14.2023, https://reason.com/2023/02/14/we-need-new-laws-to-protect-people-in-pain/

65. Weissman DE, Haddox JD. Opioid pseudo-addiction—an iatrogenic syndrome. Pain. (1989) 36:363–6. doi: 10.1016/0304-3959(89)90097-3

66. Fishbain DA, Cole B, Lewis J, Rosomoff HL, Rosomof RS. What percentage of chronic nonmalignant pain patients exposed to chronic opioid analgesic therapy develop abuse/addiction and/or aberrant drug-related behaviors? a structured evidence-based review. Pain Med. (2008) 9:445–59. doi: 10.1111/j.1526-4637.2007.00370.x

67. Nadeau SE and Lawhern RA “Management of Chronic Non-Cancer Pain: A Framework” Pain Manag 2022;12(6):751-777. DOI: 10.2217/pmt-2022-0017

68. Schneider JP, “A Practical Introduction To The Use of Opioids For Chronic Pain”, Practical Pain Management, November December 2009. https://www.practicalpainmanagement.com/author/2460/schneider

69. Richard A Lawhern, “How Would Opioid Prescription Guidelines Read if Pain Patients Wrote Them?” National Pain Report, April 2017, Re-published June 2022, https://nationalpainreport.com/how-would-opioid-prescription-guidelines-read-if-pain-patients-wrote-them-8833330.html

Featured in Pain Week as “What If Prescribing Guidelines Were Patient Centered”, Pain Week (Pain Policy), April 17, 2017, https://www.painweek.org/media/news/what-if-prescribing-guidelines-were-patient-centered

70. Federation of State Medical Boards “Guidelines for the Chronic Use of Opioid Analgesics”, April 2017, https://www.fsmb.org/siteassets/advocacy/policies/opioid_guidelines_as_adopted_april-2017_final.pdf

71. Ask the Expert: “Do NSAIDs Cause More Deaths Than Opioids?”. Pract Pain Manag. 2013;13(10). https://www.practicalpainmanagement.com/treatments/pharmacological/opioids/ask-expert-do-nsaids-cause-more-deaths-opioids

72. Harper DC “Misuse of ‘Hyperalgesia’ to Limit Care”, Journal of Practical Pain Management, March 7, 2011. https://www.practicalpainmanagement.com/treatments/pharmacological/opioids/misuse-hyperalgesia-limit-care

73. Hardin N, “Opioid Induced Hyperalgesia – Exploring Myth and Reality”, Pain Week, 2016, https://www.youtube.com/watch?v=1NpM8NTSVJI

74. Tennant F “Opioid Treatment Ten-Year Longevity Survey – Final Report” Pract Pain Manag. 2010;10(1). https://www.practicalpainmanagement.com/treatments/pharmacological/opioids/opioid-treatment-10-year-longevity-survey-final-report

75. Manougian E, “Why Some Patients Require High Dose Opioid Therapy. Pract Pain Manag. 2010;10(6). https://www.practicalpainmanagement.com/treatments/pharmacological/opioids/why-some-patients-require-high-dose-opioid-therapy