Serum levels of Nitric Oxide metabolites in relation to Body Mass Index and Arterial stiffness in young individuals

Article Sidebar

PDF Download
Published Dec 26, 2023
DOI: https://doi.org/10.18103/mra.v11i12.4798

Downloads

Download data is not yet available.

Submit your own article

Register as an author to reserve your spot in the next issue of the Medical Research Archives.

Author Registration

Join the Society

The European Society of Medicine is more than a professional association. We are a community. Our members work in countries across the globe, yet are united by a common goal: to promote health and health equity, around the world.

Join Europe’s leading medical society and discover the many advantages of membership, including free article publication.

Membership

Main Article Content

VIDYA GANJI
Assistant Professor, Physiology, All India Institute of Medical Sciences, Bibinagar
MADHURI TARANIKANTI
Additional Professor, Physiology, All India Institute of Medical Sciences, Bibinagar
MADHULATHA KARRE
Assistant Professor, Biochemistry, All India Institute of Medical Sciences, Bibinagar
KALPANA M
Associate Professor, Physiology, All India Institute of Medical Sciences, Bibinagar
NITIN A ASHOK JOHN
Professor, Physiology, All India Institute of Medical Sciences, Bibinagar
MADHUSUDHAN U
Assistant Professor, Physiology, All India Institute of Medical Sciences, Bibinagar
ARCHANA GAUR
Assistant Professor, Physiology, All India Institute of Medical Sciences, Bibinagar

Abstract

Introduction: Obesity is a multi-factorial disorder defined as abnormally high levels of body fat accumulation. It is a major emerging pandemic of this century which can be attributed to alterations in eating habits, lifestyle choices and rise in sedentary behaviour. The activation of pro-inflammatory signalling pathways linked to obesity can result in vascular endothelial dysfunction and changed levels of Nitric oxide (NO). Hyperlipidaemia may exacerbate arterial stiffness which is a precursor to atherosclerosis. In this study, we tried to evaluate the changes in levels of nitric oxide in obese individuals and its association with arterial stiffness.


Objectives: To identify the association of serum levels of Nitric oxide metabolites with Body Mass Index (BMI) in apparently healthy subjects.


  1. To evaluate any correlation between serum nitric oxide metabolites, BMI and arterial stiffness in obese individuals.

Result: The results showed a significant increase in systolic blood pressure (p<0.001) and no change in diastolic blood pressure and significant increase in pulse pressure(p<0.001) with increase in visceral adiposity (Waist Circumference) more than BMI. Results of Pearson correlation indicated that there is a significant small negative relationship between BMI and Serum NO levels, (r =- 0.534, p <.001). There was significant increase in Brachial ankle Pulse Wave Velocity (Ba PWV) (p=0.001) and Carotid Femoral Pulse Wave Velocity (CF PWV) (p=0.01) in obese subjects when compared to controls.


Conclusion: Our study results showed that abdominal obesity more than overall obesity is more strongly associated with decreased serum NO levels and increased arterial stiffness. In obese individuals, increased arterial stiffness as reflected by increased pulse wave velocity may contribute to predicting cardiovascular disease in both genders in addition to development of hypertension.

Keywords: BMI, Obesity, Arterial stiffness (AS), serum NOx (Nitric oxide metabolites) levels, Brachial ankle Pulse Wave Velocity (baPWV),, Carotid Femoral PWV (CFPWV)

Article Details

How to Cite
GANJI, VIDYA et al. Serum levels of Nitric Oxide metabolites in relation to Body Mass Index and Arterial stiffness in young individuals. Medical Research Archives, [S.l.], v. 11, n. 12, dec. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4798>. Date accessed: 15 may 2024. doi: https://doi.org/10.18103/mra.v11i12.4798.
ABNT APA BibTeX CBE EndNote - EndNote format (Macintosh & Windows) MLA ProCite - RIS format (Macintosh & Windows) RefWorks Reference Manager - RIS format (Windows only) Turabian
Issue
Vol 11 No 12 (2023): December Issue, Vol.11, Issue 12
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

References

1. NHMRC. Clinical practice guidelines for the management of overweight and obesity in adults. Treatment. Canberra, ACTNHMRC.2003,81-106.
2. Aroor AR, Jia G, Sowers JR. Cellular mechanisms underlying obesity-induced arterial stiffness. Am J Physiol Regul Integr Comp Physiol.2018;314(3):387-398.
3. Miranda K M, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric oxide. 2001;5(1):62-71.
4. Raddino R, Caretta G, Teli M, Bonadei I et al: Nitric oxide and cardiovascular risk factors: Heart Int:2007;3(1):18.
5. Ghasemi A, Zahediasl S, Azizi F. Elevated Nitic oxide metabolites are associated with obesity in women. Arch Iran Med. 2013; 16(9): 521-525.
6. Perreault M, Marette A. Targeted distribution of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med.2001;7(10):1138-1143.
7. Dallaire P, Marette A. Obesity-linked insulin resistance. Is nitric oxide the missing link? Can J Diabetes.2004;28:59-66.
8. Gruber HJ, Mayer C, Mangge H, Fauler G et al. Obesity reduces the bioavailability of nitric oxide in juveniles: Int J Obesity: 2008;32(5),826-831.
9. Ahmed N, Adam SI, Nawi AM et al. Abdominal obesity indicators: Waist circumference or waist-to-hip ratio in Malaysian adult population. Int J Prev Med. 2016 Jun; 7:82.
10. Fisher E, Brzezinski RY, Ehrenwald M et al. Increase in Body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 yrs follow up. Int J Obes.2019;43(4):800-807.
11. Cox BD, Whichelow MJ, Ashwell M, Prevost AT et al. Association of anthropometric indices with elevated blood pressure in British adults. Int J Obes Relat Metab Disord. 1997; 21(8):674-80.
12. Xie M, Burchfield JS, Hill JA. Pathological ventricular remodeling: therapies: Part 1 and 2. Circulation.2013;128(9):1021-30.
13. Hirakawa Y, Tai-Hing Lam, Timothi Welborn et al. The impact of body mass index on the association of lipids with the risk of coronary heart disease in the Asia pacific region. Prev Med Rep. 2016; 3:79-82.
14. Rostamzadeh F, Najafipour H, Yazdani R, Nakhaei S et al. Changes in serum levels of apelin and nitric oxide in hospitalized patients with COVID-19: Association with hypertension, diabetes, obesity and severity of disease. Eur J Med Res:2022; 27(1):243.
15. Viera Van Keulin H, Da Silva Gomes A et al: Serum concentration of nitric oxide in women smokers and nonsmokers with overweight.2015: Nutr Hosp:2015;32(4):1493-1499.
16. Brian E. Sansbury, Bradford G. Hill. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med.2014; 73: 383-399.
17. Brian E. Sansbury, Bradford G. Hill. Anti-obesogenic role of endothelial nitric oxide synthase. Vitam Horm. 2014; 96;323-346.
18. Valerio A, Cardio A, Cozzi V, Bracale R et al. TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. The Journal of Clin Inv.2006;116(10):2791-8.
19. Engeli S, Janke J, Gorzelniak K, Bohnke J et al. Regulation of the nitric oxide system in human adipose tissue. J Lipid Res.2004; 45(9):1640-8.
20. Lubos E, Handi DE, Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci.2008;13:5323-5344.
21. Foroumandi E, Alizadeh M, Kheirouri S, Asghari Jafarabadi M: Exploring the role of body mass index in relationship of serum nitric oxide and advanced glycation end products in apparently healthy subjects: PLOS ONE.2019;14(3): 2019: e0213307.
22. Goswami B, Sarkar S, Sengupta S, Bhattacharjee B. Assessment of serum nitric oxide levels and its correlation with anthropometric parameters and lipid profile in diabetic patients: A hospital-based study from Tripura. J Family Med Prim Care.2022: 11(9): 5161-5165.
23. Choi JW. Enhanced nitric oxide production is closely associated with serum lipid concentrations in adolescents. Clinica Chimica Acta. 2004; 347(1-2):151-6
24. Codoner- Franch P, Tavarez-Alanso S, Murria-Estal R et al. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis.2011;215:475-80.
25. Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Zurakowski A. Serum concentrations of Nitric oxide, tumor necrosis factor-alpha and TNF soluble receptors in women with overweight and obesity. Metabolism.2004;53(10),1268-1273.
26. Fujita K, Wada K, Nozaki Y, Yoneda M et al. Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: Clinical significance of measurement for nitrate/nitrite. Med Sci Monit.2011;17:CR123-31.
27. Vitale E, Jirilo E, Magrone T. Correlations between the youth healthy eating index, body mass index and salivary nitric oxide concentrations in overweight/obese children. Endocr Metab Immune Disord Drug Targets.2014;14(2):93-101.
28. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J. Am. Coll. Cardiol. 2010;55:1318–1327.
29. Sugawara J, Hayashi K, Yokoi T, et al. Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J. Hum. Hypertens. 2005;19:401–406
30. Robert M.W, Tina S, Leona A.S, Jessica L et al. Arterial stiffness precedes systolic hypertension in Diet-induced obesity. Hypertension;2013;62:1105-1110.
31. Safar, Michael E. Obesity, Arterial stiffness and cardiovascular risk. Journal of the American society of nephrology. 2006;17:4(2);109-111.
32. Ohkuma T, Ninomiya T, Tomitama H, Kario K et al. Collaborative group of J-BAVEL. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: An individual participant Data Meta-analysis.Hypertension.2017 Jun; 69(6): 1045-1052.
33. Annayya R.A, Jia G,James R.Sowers. cellular mechanisms underlying obesity-induced arterial stiffness.AM J Physiol Regul Integr Comp Physiol.2018;314(3):R387-R398.
34. Cooper LL, Palmisano JN, Benjamin EJ et al. Microvascular function contributes to the relation between aortic stiffness and cardiovascular events: the Framingham Heart study. Circ Cardiovasc Imaging 9:2016:e004979
35. Cooper JN, Tepper P, Barinas-Mitchell E, et al. Changes in serum Aldosterone Is associated with changes in obesity-related factors in normotensive Overweight and Obese Young Adults. Hypertens Res. 2013;36(10):895-901
36. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932–943.
37. Logan JG, Kang H, Kim S et al. Association of obesity with arterial stiffness: The multi-centric study of Atherosclerosis(MESA). Vasc Med. 2020; 25(4):309-318.
38. Kim HL, Ahn DW, Kim S.H. et al. Association between body fat parameters and arterial stiffness. Sci Rep. 2021; 11,20536.