An Uncommon Association Between Hydroxycut® Supplement and Atypical Takotsubo Cardiomyopathy: A Case Report
Main Article Content
Abstract
Hydroxycut®, an herbal supplement used for weight loss, is known to be associated with multiple side effects with cardiac dysrhythmias being amongst the rarer events. In this case, we report a 69-year-old female presenting after her first dose of Hydroxycut Max® supplement resulting in an atypical variant of Takotsubo cardiomyopathy. She presented with symptoms concerning acute coronary syndrome and rapid hemodynamic compromise. Her coronary angiogram showed no obstructive coronary artery disease. The left ventriculogram and transesophageal echocardiogram were suggestive of mid ventricular Takotsubo cardiomyopathy.
We further discuss, with the aid of current literature, how caffeine and robusta coffee bean extract, two ingredients in Hydroxycut® products can lead to increased sympathetic tone of the myocardium and decreased myocardial perfusion potentially triggering her cardiomyopathy. This will be the first reported case of Hydroxycut® induced Takotsubo cardiomyopathy in literature.
Article Details
How to Cite
AMARATUNGA, Dhanushya Thamaransi et al.
An Uncommon Association Between Hydroxycut® Supplement and Atypical Takotsubo Cardiomyopathy: A Case Report.
Medical Research Archives, [S.l.], v. 11, n. 12, dec. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/4883>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v11i12.4883.
Section
Case Reports
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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10. Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-148.
11. Sivarajah V, Abdul Q, Pardoe H, Lunniss P. Ulcerative colitis associated with the herbal weight loss supplement Hydroxycut. BMJ Case Rep. 2013;2013.
12. Willis SL, Moawad FJ, Hartzell JD, Iglesias M, Jackson WL. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed. 2006;8(3):82.
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18. Robles P, Monedero I, Rubio A, Botas J. Reverse or inverted apical ballooning in a case of refeeding syndrome. World J Cardiol. 2015;7(6):361-366.
19. Tagami T, Mertens A, Rothschild D, Chowdhury P. A case of reverse takotsubo cardiomyopathy caused by an eating disorder. J Cardiol Cases. 2017;15(3):77-79.
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24. Gervais MK, Gagnon A, Henri M, Bendavid Y. Pheochromocytoma presenting as inverted Takotsubo cardiomyopathy: a case report and review of the literature. J Cardiovasc Med (Hagerstown). 2015;16 Suppl 2:S113-117.
25. Kido K, Guglin M. Drug-Induced Takotsubo Cardiomyopathy. J Cardiovasc Pharmacol Ther. 2017;22(6):552-563.
26. Hajsadeghi S, Rahbar MH, Iranpour A, Salehi A, Asadi O, Jafarian SR. Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report. Anatol J Cardiol. 2018;19(6):412-416.
27. Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155(3):408-417.
28. Moazez C, Zeitjian V, Mehdizadeh A. A Unique Case of Midvariant Reverse Takotsubo Cardiomyopathy. Case Reports in Cardiology. 2018;2018:2184792.
29. Kaoukis A, Panagopoulou V, Mojibian HR, Jacoby D. Reverse Takotsubo cardiomyopathy associated with the consumption of an energy drink. Circulation. 2012;125(12):1584-1585.
30. Dai Z, Fukuda T, Kinoshita K, Komiyama N. Inverted Takotsubo Cardiomyopathy Associated With the Consumption of a Weight Management Supplement. CJC Open. 2020;2(1):26-29.
31. Kuijpers D, Prakken NH, Vliegenthart R, van Dijkman PR, van der Harst P, Oudkerk M. Caffeine intake inverts the effect of adenosine on myocardial perfusion during stress as measured by T1 mapping. Int J Cardiovasc Imaging. 2016;32(10):1545-1553.
32. Higgins JP, Babu KM. Caffeine reduces myocardial blood flow during exercise. Am J Med. 2013;126(8):730 e731-738.
33. Cvetanovich GL, Ramakrishnan P, Klein JP, Rao VR, Ropper AH. Reversible cerebral vasoconstriction syndrome in a patient taking citalopram and Hydroxycut: a case report. J Med Case Rep. 2011;5:548.
2. Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced Liver Toxicity. Ann Med Health Sci Res. 2014;4(1):143-145.
3. Araujo JL, Worman HJ. Acute liver injury associated with a newer formulation of the herbal weight loss supplement Hydroxycut. BMJ Case Rep. 2015;2015.
4. Yellapu RK, Mittal V, Grewal P, Fiel M, Schiano T. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can J Gastroenterol. 2011;25(3):157-160.
5. Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008;14(45):6999-7004.
6. Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.
7. Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut((R)) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010;69(8):188-190.
8. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy. 2001;21(5):647-651.
9. Carol ML. Hydroxycut weight loss dietary supplements: a contributing factor in the development of exertional rhabdomyolysis in three U.S. Army soldiers. Mil Med. 2013;178(9):e1039-1042.
10. Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-148.
11. Sivarajah V, Abdul Q, Pardoe H, Lunniss P. Ulcerative colitis associated with the herbal weight loss supplement Hydroxycut. BMJ Case Rep. 2013;2013.
12. Willis SL, Moawad FJ, Hartzell JD, Iglesias M, Jackson WL. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed. 2006;8(3):82.
13. Zaidan J, Tabet R, Karam B, Daneshvar F, Raza M, Bekheit S. Asystole caused by Hydroxycut Hardcore: A case report and literature review. Ann Noninvasive Electrocardiol. 2018;23(3):e12479.
14. nayat F, Majeed CN, Ali NS, Hayat M, Vasim I. The risky side of weight-loss dietary supplements: disrupting arrhythmias causing sudden cardiac arrest. BMJ Case Rep. 2018;11(1).
15. Hammond DA, Thano E, Bohnenberger KA, et al. Ventricular Tachycardia Precipitated by the Use of the Diet Supplement Hydroxycut Gummies. Hosp Pharm. 2015;50(7):615-618.
16. Karth A, Holoshitz N, Kavinsky CJ, Trohman R, McBride BF. A case report of atrial fibrillation potentially induced by hydroxycut: a multicomponent dietary weight loss supplement devoid of sympathomimetic amines. J Pharm Pract. 2010;23(3):245-249.
17. Hafeez Y, Gala K. Mid-Ventricular Takotsubo Cardiomyopathy. In: StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Ketan Gala declares no relevant financial relationships with ineligible companies.2023.
18. Robles P, Monedero I, Rubio A, Botas J. Reverse or inverted apical ballooning in a case of refeeding syndrome. World J Cardiol. 2015;7(6):361-366.
19. Tagami T, Mertens A, Rothschild D, Chowdhury P. A case of reverse takotsubo cardiomyopathy caused by an eating disorder. J Cardiol Cases. 2017;15(3):77-79.
20. H B, Y Y, T K, F H. Reverse Takotsubo Cardiomyopathy and Shock Supported by Continuous Hemodiafiltration in a Patient with Anorexia Nervosa. Medical Case Reports. 2017.
21. Song BG, Chun WJ, Park YH, et al. The clinical characteristics, laboratory parameters, electrocardiographic, and echocardiographic findings of reverse or inverted takotsubo cardiomyopathy: comparison with mid or apical variant. Clin Cardiol. 2011;34(11):693-699.
22. Awad HH, McNeal AR, Goyal H. Reverse Takotsubo cardiomyopathy: a comprehensive review. Ann Transl Med. 2018;6(23):460.
23. Pierard S, Vinetti M, Hantson P. Inverted (Reverse) Takotsubo Cardiomyopathy following Cerebellar Hemorrhage. Case Rep Cardiol. 2014;2014:781926.
24. Gervais MK, Gagnon A, Henri M, Bendavid Y. Pheochromocytoma presenting as inverted Takotsubo cardiomyopathy: a case report and review of the literature. J Cardiovasc Med (Hagerstown). 2015;16 Suppl 2:S113-117.
25. Kido K, Guglin M. Drug-Induced Takotsubo Cardiomyopathy. J Cardiovasc Pharmacol Ther. 2017;22(6):552-563.
26. Hajsadeghi S, Rahbar MH, Iranpour A, Salehi A, Asadi O, Jafarian SR. Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report. Anatol J Cardiol. 2018;19(6):412-416.
27. Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155(3):408-417.
28. Moazez C, Zeitjian V, Mehdizadeh A. A Unique Case of Midvariant Reverse Takotsubo Cardiomyopathy. Case Reports in Cardiology. 2018;2018:2184792.
29. Kaoukis A, Panagopoulou V, Mojibian HR, Jacoby D. Reverse Takotsubo cardiomyopathy associated with the consumption of an energy drink. Circulation. 2012;125(12):1584-1585.
30. Dai Z, Fukuda T, Kinoshita K, Komiyama N. Inverted Takotsubo Cardiomyopathy Associated With the Consumption of a Weight Management Supplement. CJC Open. 2020;2(1):26-29.
31. Kuijpers D, Prakken NH, Vliegenthart R, van Dijkman PR, van der Harst P, Oudkerk M. Caffeine intake inverts the effect of adenosine on myocardial perfusion during stress as measured by T1 mapping. Int J Cardiovasc Imaging. 2016;32(10):1545-1553.
32. Higgins JP, Babu KM. Caffeine reduces myocardial blood flow during exercise. Am J Med. 2013;126(8):730 e731-738.
33. Cvetanovich GL, Ramakrishnan P, Klein JP, Rao VR, Ropper AH. Reversible cerebral vasoconstriction syndrome in a patient taking citalopram and Hydroxycut: a case report. J Med Case Rep. 2011;5:548.