Alterations in Cortical Thickness in Children with Congenital Strabismus and Dissociated Vertical Deviation

Main Article Content

Martín Gallegos-Duarte Jorge Domingo Mendiola-Sántibañez

Abstract

Introduction: Little is known about the morphometric changes that occur in the cerebral cortex of children with congenital strabismus and Dissociated Vertical Deviation (DVD). Mathematical morphology provides the opportunity to discover alterations in cortical thickness.


Objective: Identify and measure differences in cortical thickness in children with congenital strabismus and DVD.


Materials and Methods: Twenty-two MRI brain studies were conducted, each comprising 120 sagittal slices of 1 mm. A cohort of 11 healthy children formed the control group, and a cohort of 11 children with congenital strabismus and Dissociated Vertical Deviation, both in Dissociated Esotropia and Dissociated Exotropia formed the case group. Differences in cortical thickness between both groups were compared and identified using the FreeSurfer suite. Subsequently, areas of interest were analyzed using the ImageJ program to determine density, area, size, and pixel quantity in these regions. Study results are presented through tables and figures.


Results: Twelve inflated brain projections were obtained from 2640 MRI images. Thickness differences between both groups exhibited three areas with significant morphometric changes: the Left Angular Gyrus, Left Supramarginal Gyrus, and Right Pars Opercularis.


Discussion: Children with congenital strabismus and DVD showed changes in cortical thickness that could be identified and measured through Voxel-Based Morphometry (VBM). It is plausible to consider that these changes are related to suppression, aiming to avoid diplopia.

Keywords: VBM, neural substrate, plasticity, congenital strabismus, morphology, Angular Gyrus

Article Details

How to Cite
GALLEGOS-DUARTE, Martín; MENDIOLA-SÁNTIBAÑEZ, Jorge Domingo. Alterations in Cortical Thickness in Children with Congenital Strabismus and Dissociated Vertical Deviation. Medical Research Archives, [S.l.], v. 12, n. 1, jan. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4901>. Date accessed: 03 mar. 2024. doi: https://doi.org/10.18103/mra.v12i1.4901.
Section
Research Articles

References

1. Engle EC. Genetic basis of congenital strabismus. Archives of ophthalmology. 2007; 125(2):189.

2. Bridgeman: The Theory of Binocular Vision: Ewald... - Google Académico. Accessed November 6, 2023. https://scholar.google.com/scholar_lookup?title=The%20Theory%20of%20Binocular%20Vision%3A%20Ewald%20Hering%20%281868%29&author=B%20Bridgeman&author=L%20Stark&publication_year=1977&book=The%20Theory%20of%20Binocular%20Vision%3A%20Ewald%20Hering%20%281868%29

3. Thompson B, Maehara G, Goddard E, Farivar R, Mansouri B, Hess RF. Long-Range Interocular Suppression in Adults with Strabismic Amblyopia: A Pilot fMRI Study. Vision. 2019;3(1):2. doi:10.3390/vision3010002

4. Economides JR, Adams DL, Horton JC. Interocular Suppression in Primary Visual Cortex in Strabismus. J Neurosci. 2021;41(25): 5522-5533. doi:10.1523/JNEUROSCI.0044-21.2021

5. Mechelli A, Crinion JT, Long S, et al. Dissociating reading processes on the basis of neuronal interactions. Journal of cognitive neuroscience. 2005;17(11):1753-1765.

6. Gallegos-Duarte M M. Dissociated Vertical Divergence. Strabismus. 2012;20(1):31-32. doi:10.3109/09273972.2011.651769

7. ten Tusscher MPM. Dissociated Deviation in the Infantile Strabismus Syndrome. Strabismus. 2012;20(1):33-34. doi:10.3109/09 273972.2011.650816

8. Mendiola Santibañez MSJ, Gallegos-Duarte M, Ortiz-Retana JJ, López-Campos CE. Segmentación y análisis granulométrico de sustancia blanca y gris en IRM para el estudio del estrabismo usando transformaciones morfológicas. 2007;28(2):92-104.

9. Mendola JD, Conner IP, Roy A, et al. Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia. Human Brain Mapping. 2005;25(2):222-236. doi:10.1002/hbm.20109

10. Ouyang J, Yang L, Huang X, et al. The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. Mol Med Rep. 2017;16(3):3276-3282. doi:10.3892 /mmr.2017.7006

11. Gallegos-Duarte M. Comportamiento de la coherencia bioléctrica cortical en el estrabismo congénito. Tesis Doctoral. Universidad Autónoma de Querétaro; 2017.