Physiological Function of Oligosaccharides in Teleost Blood

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Published Jan 31, 2024
DOI: https://doi.org/10.18103/mra.v12i1.4999

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Main Article Content

Takahiko Aoki
Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Tsu, Mie 514-8507, Japan

Abstract

Oligosaccharides in human blood are involved in various blood group antigens. Sialo-oligosaccharide-rich glycoproteins (GPs) in red blood cell (RBC) membranes also carry M, N, Ss and other blood group antigens. However, teleost blood is not expressed as a blood group antigen. Our study showed that carp, yellow tail and red sea bream GPs exhibit broad-spectrum antibiotic activity. This bacteriostatic activity is caused by the sialo-oligosaccharides from GPs.


Based on NMR and GC–MS results, the structure of the bacteriostatic sialo-oligosaccharide from carp GP was determined to be NeuGcα2→6(Fucα1→4) (Glcα1→3) Galβ1→4GalNAc-ol. Compared to carp pentose, the structure of human GP O-linked tetra- or tri-oligosaccharides is simpler. In addition, NeuAc is simpler in human GPs than in carp NeuGc.


In contrast to human blood, teleost blood does not contain IgG, and other antibodies occur at low levels. Teleost GPs may act as substitutes for antibodies, such as IgG, in the immune system. In this review, the transformation of the physiological function of oligosaccharides with respect to their structure is described.

Keywords: teleost, red blood cell membranes, glycophorin, antibiotic activity, blood group antigen, immune system

Article Details

How to Cite
AOKI, Takahiko. Physiological Function of Oligosaccharides in Teleost Blood. Medical Research Archives, [S.l.], v. 12, n. 1, jan. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4999>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.18103/mra.v12i1.4999.
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Issue
Vol 12 No 1 (2024): January Issue, Vol.12, Issue 1
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Research Articles

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