Introduction. - In this review, one of the mechanisms that is generated in inflammation, oxidative stress, was analyzed. Inflammation is an immune system response, it is essential for survival and recovery, but it can cause damage to the body, due to oxid

Main Article Content

Luis-Eder Vargas-Campos Marco-A. Adams-Reyes Julio-Cesar Adams-Ocampo Juan-Manuel Luna-Gomez Yanet Medina-Rojas Luis-Martin Vargas-Zuñiga

Abstract

Introduction. - In this review, one of the mechanisms that is generated in inflammation, oxidative stress, was analyzed. Inflammation is an immune system response, it is essential for survival and recovery, but it can cause damage to the body, due to oxidative stress that occurs when there is an imbalance between the production of reactive oxygen species and the body's ability to neutralize them with Endogenous antioxidants contribute to the development of chronic diseases such as cardiovascular, diabetes, autoimmune diseases, cancer, neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis.


Aim. - Evaluate the literature about Inflammation from the basic to the clinical.


Methodology. - Databases such as MEDLINE/PubMed and ScienceDirect regarding Inflammation were analyzed.


Results. - Despite recent advances in the understanding of inflammation and oxidative stress, there are still important challenges in the study and treatment of these conditions, on the one hand, it is necessary to develop more precise biomarkers to evaluate oxidative stress and inflammation in the patients. While in the other, new therapeutic approaches are needed to modulate inflammation and oxidative stress more effectively and specifically.


Conclusion. - That the study of inflammation and oxidative stress is crucial to understanding the pathophysiological bases of various chronic diseases and that advances in the field of inflammation and oxidative stress have provided new therapeutic perspectives for the treatment and prevention of chronic diseases.

Keywords: Inflammation, oxidative stress, reactive oxygen species and chronic diseases

Article Details

How to Cite
VARGAS-CAMPOS, Luis-Eder et al. Introduction. - In this review, one of the mechanisms that is generated in inflammation, oxidative stress, was analyzed. Inflammation is an immune system response, it is essential for survival and recovery, but it can cause damage to the body, due to oxid. Medical Research Archives, [S.l.], v. 12, n. 1, jan. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5072>. Date accessed: 15 may 2024. doi: https://doi.org/10.18103/mra.v12i1.5072.
Section
Review Articles

References

1. Kumar V, Abbas AK, Fausto N, Mitchell RN. Acute and chronic inflammation. En: Saunders (Elsevier). Robbins & Cotran Pathologic Basis of Disease. 8th. ed. New York: McGraw-Hill Interamericana; 2007: p. 58-31

2. Cook JM, Deem TL. Active participation of endothelial cells in inflammation. J Leukoc Biol. 2005;77(4):487-95 63] Cabezas R, et al., PDGF-BB Protects Mitochondria from Rotenone in T98G Cells. Neurotox Res 2014;

3. Akinmoladun, AC, Ibukun, EO, Afor, E., Obuotor, EM, y Farombi, EO (2007). Constituyente fitoquímico y actividad antioxidante del extracto de las hojas de Ocimum gratissimum. Scientific Research and Essays, 2 (5), 163-166.

4.Halliwell, B., & Gutteridge, JM (2015). Radicales libres en biología y medicina Oxford University Press, EE. UU.

5. Flohé, et al 1985. The Glutathione Peroxidase Reaction: Molecular Basis of the Antioxidant Function of Selenium in Mammals. Current Topics in Cellular Regulation. Volume 27, 1985, Pages 473-478.

6. James K. Hurst William C. Barrette. 1989. Leukocytic Oxygen Activation and Microbicidal Oxidative Toxin. Critical Reviews in Biochemistry and Molecular Biology 24(4):271-328.

7, Rice-Evans et al 1993. Current status of antioxidant therapy. Free Radical Biology and Medicine. Volume 15, Issue 1, July 1993, Pages 77-96

8. Cuzzocrea et al 2000. Inducible Nitric Oxide Synthase—Knockout Mice Exhibit Resistance to Pleurisy and Lung Injury Caused by Carrageenan. American Journal of Respiratory and Critical Care Medicine.

9. Konigsberg, M. (2008). Radicales libres y estrés oxidativo. Aplicaciones Médicas. El Manual Moderno. México, D.F.

10. Rice-Evans y Miller 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med.1996;20(7):933-56.

11. Vélez Alavez Marcela 2009. Indicadores de estrés oxidativo relacionado con la presencia de elementos trazas (plomo, cadmio, mercurio y arsénico), en diferentes tejidos de tiburón mako (Isurus oxyrinchus). Tesis para obtener el grado de maestro en ciencias, Centro de Investigaciones Biológicas del Noroeste, S.C. México.

12. Muñoz-Velázquez Erika Elizabeth, Rivas-Díaz Karla, Loarca-Piña Ma. Guadalupe Flavia, Mendoza-Díaz Sandra, Reynoso-Camacho Rosalía y Ramos-13. Gómez Minerva. 2012. Comparación del contenido fenólico, capacidad antioxidante y actividad antiinflamatoria de infusiones herbales comerciales. Revista mexicana de ciencias agrícolas versión impresa ISSN 2007-0934.

14. García Triana Barbara E, Saldaña Bernabeu Alberto, Saldaña García Leticia 2013. El estrés oxidativo y los antioxidantes en la prevención del cáncer. Rev haban cienc méd vol.12 no.2 Ciudad de La Habana abr.-jun. 2013.

15. Espinosa-Jiménez Evi Amram, Adams Ocampo Julio Cesar, Muñuzuri Arana Hilda Lourdes y Vargas Zuñiga Luis Martin 2018. Biomarcadores de Estrés Oxidativo en niños con cancer y sanos. Tesis para obtener el grado de licenciado en Médico Cirujano Dentista. Acapulco de Juarez Gro., México.

16. McKee, T. y McKee, J. R. Moléculas Antioxidantes. Agresión Oxidativa. Bioquímica. La Base Molecular de la Vida (3ªed). McGraw- Hill Interamericana (2003).

17. Vignais, P. The superoxide-generating NADH oxídate: strutural aspects and activation Mechanism. MCLS. Life Sci 59, 1428 - 1459 (2002).

18. Grisham M., Granger D. Neutrophil-mediated mucosal injury. Digestive Diseases and Sciences 53, 6S-15S (1988).

19. Carvajal Carvajal Carlos. El endotelio: estructura, función y disfunción endotelial. Med. leg. Costa Rica vol.34 n.2 Heredia Sep./Dec. 2017.

20. González Mendoza Daniel. Complejo enzimático citocromo P450 monooxigenasa en plantas. Agric. Téc. Méx vol.35 no.2 México abr./jun. 2009.

21. Chirino I Yolanda, Orozco–lbarra Marisol y Pedraza–Chaverri José. Evidencias de la participación del peroxinitrito en diversas enfermedades. Rev. invest. clín. vol.58 no.4 Ciudad de México jul./ago. 2006.

22. Poole, R.K. (2005). Nitric oxide and nitrosative stress tolerance in bacteria. Biochem. Soc. Trans. 33, 176– 180.

23. Rossi Pablo Juan. La combinación de los azúcares con las biomoléculas. Desde la cocina al organismo. Medicina (B. Aires) v.67 n.2 Buenos Aires mar./abr. 2007.

24. Cabezas R, et al., PDGF-BB Protects Mitochondria from Rotenone in T98G Cells. Neurotox Res 2014;

25. Ahmad A, et al., Brain region specific monoamine and oxidative changes during restraint stress. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 2012; 39(3): 311-318.

26. Ahmad A, et al., Novel Ocimum sanctum compounds modulate stress response: Role of CRF, POMC, GR and HSP-70 in the hypothalamus and pituitary of rats. Medicinal Plants - International Journal of Phytomedicines and Related Industries 2013; 5(4).

27. Ahmad A, et al., Novel Ocimumoside A and B as antiestrés agents: modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 2012; 19(7): 639-647.

28. Chao Y, S.C. Wong, and E.K. Tan, Evidence of Inflammatory System Involvement in Parkinsons Disease. BioMed Research International 2014; 2014.

29. Barreto GE, M. Santos-Galindo, and L.M. Garcia-Segura, Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury. Front Aging Neurosci 2014; 6: 132.

30. Landskron G, et al., Chronic Inflammation and Cytokines in the Tumor Microenvironment. Journal of Immunology Research 2014; 2014

31. Lau FC, B. Shukitt-Hale, and J.A. Joseph, Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. Subcell Biochem 2007; 42: 299-318.

32. Palmer HJ, Paulson KE. Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 55:353-61; 1997

33. Abe J, Berk, BC. Reactive oxygen species as mediators of signal transduction in cardiovascular disease. Trends Cardiovas Med 8:59-64; 1998.

34. Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 22:269-85; 1997

35. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, et al Mitogenic signalling mediated by oxidants in Ras-transformed fibroblasts. Science 265:808-11; 1997.

36. Abe J, Takahaashi M, Ishida M, Lee J-G, Berk BC. c-Src is required for oxidative stress-mediated activation of big mitogen activated protein kinase (BMK1). J Bio Chem 33:20389-94; 1997.

37. Loscalzo J. The oxidative stress of hyperhomocysteinemia. J Clin Invest 98:5-7; 1996.

38. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirements for generatin of H2O2 for PDGF signal transduction. Science 270:296-99; 1995.