Visualisation and Evaluation Study of Some Patients Arteriosclerosis Microvessel with Coronary Artery Disease at Coronary Artery Bypass Grafting

Main Article Content

Kukurtchyan N.S. Karapetyan G.R.

Abstract

Visualization of coronary microvessel at ischemic disease still remains actual. There is necessity for additional study of arteriosclerosis microvessels.


The byoptates of auricular right atria of patients with coronary artery disease were taken at coronary artery bypass grafting. The epoxy slices were obtained from material treated by the method of transmission electron microscopy and fixed in epoxy resins with further staining by Azur II and viewed under light optical microscope.


Analysis of the images obtained during this study identified different arteriosclerotic damages, with negative phenomena of convolute formation in the walls of arteriolas and formation of de Novo arteriolas from previous one, by intussusception type that could also lead to ischemia.


Evaluation on 5-degree scale of pathological growth of vessels microcirculatory bed as well as provided 1-2 images could help during analyze of arteriosclerotic damages, identification of pathological process direction in each patient case.


This will improve medical treatment of such patients in postsurgical period.

Keywords: coronary artery disease, microvessel; images, evaluation in score, light optical microscop

Article Details

How to Cite
N.S., Kukurtchyan; G.R., Karapetyan. Visualisation and Evaluation Study of Some Patients Arteriosclerosis Microvessel with Coronary Artery Disease at Coronary Artery Bypass Grafting. Medical Research Archives, [S.l.], v. 12, n. 3, mar. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5095>. Date accessed: 13 apr. 2024. doi: https://doi.org/10.18103/mra.v12i3.5095.
Section
Case Reports

References

1. Chen O, Rosenson R.S. “ Cardiovascular Drugg Ther. Systematic Review of Method Used for Microvascular Assesmant of Peripheral Arterial Disease”, 2018, 32: 301-310
2. Fenseka D,A, Antunes, P.E., Doulce Coztin D. “The morphology, phisiology and pathophysiology of coronary microcirculation” Open access pear-reviewed chapter oct. 2016. Doi: 10.8772/6 4537
3. Feo A, Agostini J, Rapezzi C, Olivetto L, Corti B, Rotena L, Blasgini E, Snaver M, Rotelini M, Cecchi F. “Histopathological comparison of intramyral coronary artery remodeling and myocardial fibrosis in obstructive versuse end stage hypertrophic cardiomyopathy. Int J. Cardiol. 2019, 291: 77-82.
4. Kukurtchyan N.S., Karapetyan G.R. Patent Republic of Armenia 2844A, 2014
5. Kukurtchyan N.S., Karapetyan G.R. Patent Republic of Armenia 3206A, 2018
6. Kukurtchyan N.S., Karapetyan G.R. “Heart microvessels research at ischemic heart disease at open heart surgery”. European journal of Biomedical and Pharmaceutical Sciences. EJBPT, 2021, 8 (8): 71-75.
7. Kukurtchyan N.S., Karapetyan G.R. “Heart microvessels and its morphological evaluation at open heart surgery”. European journal of Biomedical and Pharmaceutical Sciences. EJBPT, 2023, 10(8)
8. Pries A.R., Regin B. Coronary microcirculatory pathophysiology j. Eur. Heart, 2017:38: 478-488. Doi: 10.1093/eucheart j/ehr 760.
9. Sharavana Gurunathen, Marie Guerraty. “Translational insights in coronary microvasculation disease” J ACC Basic to Translational Science, 2023, 8(5): 515-517, Doi: 10.1016/j.jacbts. 2023.03.021