Interactions between Immunoglobulin like receptors and the Peptidome in the Allogeneic Hematopoietic Stem Cell Transplantation in the Cytomegalovirus context. A mini review.
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Abstract
The Natural Killer cells are innate lymphoid cells that play essential roles in defense against viral and parasitic infections, elimination of tumor cells, regulation of adaptive immunity through cytotoxicity, and cytokine secretion. Fundamental knowledge about the regulation of Natural Killer cells can be applied to study their function in patients undergoing hematopoietic stem cell transplantation, with or without Cytomegalovirus reactivation. The function of Natural Killer cells is governed by a repertoire of receptors responsible for initiating intracellular activating or inhibitory signaling. The balance of this signaling directs the cytotoxic activity of these cells, as well as cell proliferation and cytokine release.Understanding the interaction of receptors expressed on the surface of Natural Killer cells with their ligands expressed on target cells is a topic of discussion in the context of alloreactivity and the graft-versus-leukemia effect in transplant patients. Recent investigations have shown that KIR/HLA interactions go beyond affinity and describe that many of them depend on the peptide being presented by the HLA at that moment. Analysis of the peptidome (HLA class I + bound peptide) has demonstrated that some Natural Killer cell receptors are peptide-dependent. Therefore, understanding these interactions by considering the entire Natural Killer cell receptor + HLA class I + peptide complex is crucial in the reestablishment of immune cells after hematopoietic stem cell transplantation, especially in the context of Cytomegalovirus reactivation, which is very common in these patients. Hence, the aim of this study is to deepen our understanding of the specificity of interactions between human Natural Killer cell KIR receptors and the peptidome in the context of Cytomegalovirus reactivation after allogeneic, related, HLA-compatible hematopoietic stem cell transplantation without T-cell depletion. For the analysis of interactions between Natural Killer cell receptors and peptidomes, specific peptide libraries for HLA class I alleles will be created to evaluate the specificities of interactions between KIR + HLA class I + peptide.
Keywords:
Natural Killer cells, peptidome, activating and inhibitory receptors, HLA class I molecules, recognition specificity
Article Details
How to Cite
CARDOZO, Daniela Maira et al.
Interactions between Immunoglobulin like receptors and the Peptidome in the Allogeneic Hematopoietic Stem Cell Transplantation in the Cytomegalovirus context. A mini review..
Medical Research Archives, [S.l.], v. 12, n. 2, feb. 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/5144>. Date accessed: 28 apr. 2024.
doi: https://doi.org/10.18103/mra.v12i2.5144.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Gasteiger G., Fan X., Dikiy S., Lee SY, Rudensky AY Residência tecidual de células linfóides inatas em órgãos linfóides e não linfóides. Ciência. 2015; 350 :981–985. doi: 10.1126/science.aac9593.
4. Seillet C., Brossay L., Vivier E. Assassinos naturais ou ILC1s? Essa é a questão. Curr. Opinião. Imunol. 2021; 68 :48–53. doi: 10.1016/j.coi.2020.08.009.
5. Bryceson YT, Março ME, Barbeiro DF, Ljunggren HG, Long EO. Polarização e degranulação citolítica de grânulos controlada por diferentes receptores em células NK em repouso. J Exp Med (2005) 202(7):1001–12. DOI: 10.1084/jem.20051143
6. Bashirova AA1, Martin MP, McVicar DW, Carrington M. The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet. 2006;7:277-300.
7. Hsu KC, Dupont B. Natural killer cell receptors: regulating innate immune responses to hematologic malignancy. Semin Hematol. 2005 Apr;42(2):91-103. doi: 10.1053/j.seminhematol.2005.01.010.
PMID: 15846575.
8. Karvouni M, Vidal-Manrique M, Lundqvist A, Alici E. Engineered NK Cells Against Cancer and Their Potential Applications Beyond. Front Immunol. 2022 Feb 15;13:825979. doi: 10.3389/fimmu.2022.825979.
PMID: 35242135; PMCID: PMC8887605.
9. Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med. 2003 Aug 18;198(4):557-67. doi: 10.1084/jem.20030788. Epub 2003 Aug 11. PMID: 12913096; PMCID: PMC2194180.
10. Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, et al.. Loss and gain of natural killer cell receptor function in an african hunter-gatherer population. PLoS Genet. (2015) 11:e1005439. 10.1371/journal.pgen.1005439
11. Hilton HG, Guethlein LA, Goyos A, Nemat-Gorgani N, Bushnell DA, Norman PJ, et al.. Polymorphic HLA-C receptors balance the functional characteristics of KIR haplotypes. J Immunol. (2015) 195:3160–70.
12. Pende D, Falco M, Vitale M, Cantoni C, Vitale C, Munari E, Bertaina A, Moretta F, Del Zotto G, Pietra G, Mingari MC, Locatelli F, Moretta L. Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation. Front Immunol. 2019 May 28;10:1179. doi: 10.3389/fimmu.2019.01179. PMID: 31231370; PMCID: PMC6558367.
13. Sim MJW, Brennan P, Wahl KL, Lu J, Rajagopalan S, Sun PD, Long EO. Innate receptors with high specificity for HLA class I-peptide complexes. Sci Immunol. 2023 Sep 8;8(87):eadh1781. doi: 10.1126/sciimmunol.adh1781.
Epub 2023 Sep 8. PMID: 37683038.
14. Zaitoua AJ, Kaur A, Raghavan M. Variations in MHC class I antigen presentation and immunopeptidome selection pathways. F1000Res. 2020 Sep 28;9:F1000 Faculty Rev-1177. doi: 10.12688/f1000research.26935.1. PMID: 33014341; PMCID: PMC7525337.
15. Raghavan M, Geng J: HLA-B polymorphisms and intracellular assembly modes. Mol Immunol. 2015;68(2 Pt A):89–93. 10.1016/j.molimm.2015.07.007
16. Garcia KC, Adams EJ. How the T cell receptor sees antigen--a structural view. Cell. 2005;122(3):333–6.
17. Malnati MS, et al. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science. 1995;267(5200):1016–8.
18. Peruzzi M, et al. Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. J Immunol. 1996;157(8):3350–6.
19. Storkus WJ, et al. Peptide-induced modulation of target cell sensitivity to natural killing. J Immunol. 1992;149(4):1185–90.
20. Zappacosta F, et al. Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. Proc Natl Acad Sci U S A. 1997;94(12):6313–8.
21. Rajagopalan S, Long EO. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. J Exp Med. 1997;185(8):1523–8.
22. Boyington JC, et al. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature. 2000;405(6786):537–43.
23. Fan QR, Long EO, Wiley DC. Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol. 2001;2(5):452–60.
24. Stewart CA, et al. Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A. 2005;102(37):13224–9.
25. Sim MJ, et al. Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C. Front Immunol. 2017;8:193.
26. Khakoo SI, Carrington M. KIR and disease: a model system or system of models? Immunol Rev. 2006 Dec;214:186-201.
27. Purdy AK, Campbell KS. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol Ther. 2009 Dec;8(23):2211-20. Epub 2009 Dec 28.
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