Tuberculosis or Sarcoidosis or the Both? A Case Report of Concomitant Tuberculosis and Sarcoidosis

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A Ajim W Elkhattabi H Arfaoui N Bougteb H Jabri M. H. Afif K Rebbouh H Tabakh A Siwane N Touil O Kacimi N Chikhaoui

Abstract

Tuberculosis and sarcoidosis are two chronic granulomatous diseases that are similar in many aspects, although different.


We report a case of 38-year-old female patient who presented a progressive shortness of breath and recurrent epistaxis associated to a night sweats and fatigue with a deterioration of general condition, in which a CT-scan showed a multiple voluminous lymphadenopathy involving all the mediastinum territories, without parenchymal abnormalities. During investigations bronchoscopy showed mucosal hypertrophy and granulations located on the nasopharyngeal walls. The biopsy of the lip and nasal’s lesion showed a non-caseating granuloma and ACE (angiotensin converting enzyme) was high, which considered sufficient to retain the diagnosis of sarcoidosis, but the blood Quantiferon-TB Gold in Tube test was positive and the excision biopsy of cervical lymphadenopathy, revealed a necrotizing granulomatous inflammation suggestive of tuberculosis. The association between sarcoidosis and tuberculosis was discussed. the patient was treated with antituberculosis drugs during six months. The evolution was marked by a progressive regression of lymph nodes. There was no significant improvement of rhinological symptoms with local corticoids. Consequently, the corticosertoide treatement in form oral was introduced during 1 month. The prednisolone was gradually tapered off after 1 month due to the complete disappearance of lesions.


The case described is suggestive of a coexistent systemic sarcoid manifestation and tuberculosis, which is an underrecognized entity in the medical literature.

Keywords: tuberculosis, sarcoidosis, granulomatous, coexistance

Article Details

How to Cite
AJIM, A et al. Tuberculosis or Sarcoidosis or the Both? A Case Report of Concomitant Tuberculosis and Sarcoidosis. Medical Research Archives, [S.l.], v. 12, n. 4, apr. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5153>. Date accessed: 03 july 2024. doi: https://doi.org/10.18103/mra.v12i4.5153.
Section
Case Reports

References

1. Hatzakis K, Siafakas NM, Bouros D.Miliary Sarcoidosis following Miliary Tuberculosis. Respiration 2000;67(2):219-222.
2. Agrawal R, Kee AR, Ang L, Tun Hang Y, Gupta V, Kon OM, et al. Tuberculosis or sarcoidosis: Opposite ends of the same disease spectrum? Tuberculosis (Edinb). mai 2016;98:21 6.
3. King EQ, Johnson JB, Batten GS, Henry WL. Tuberculosis following cortisone therapy; report of a case of rapidly progressive pulmonary tuberculosis following cortisone therapy for rheumatoid arthritis. J Am Med Assoc. 15 sept 1951;147(3):238 41. .
4. Fité E, Fernández-Figueras MT, Prats R, Vaquero M, Morera J: High prevalence of Mycobacterium tuberculosis DNA in biopsies from sarcoidosis patients from Catalonia, Spain. Respiration 2006;73:20-26.
5. Gupta D, Agarwal R, Aggarwal AN, Jindal SK. Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis. Eur Respir J 2007;30:508–516.
6. Wang SH, Chung CH, Huang TW, Tsai WC, Peng CK, Huang KL, Perng WC, Chian CF, Chien WC, Shen CH. Bidirectional association between tuberculosis and sarcoidosis. Respirology. 2019 May;24(5):467-474. doi: 10.1111/resp.13482. Epub 2019 Feb 5.
7. Mohapatra P.R., Garg K., Singhal N., Aggarwal D., Gupta R., Khurana A., et al. Tuberculosis lymphadenitis in a well managed case of sarcoidosis. Indian J Chest Dis Allied Sci. 2013;55(4):217–220.
8. Grosser M, Luther T, Füssel M, Bickhardt J, Magdolen V, Baretton G. Clinical course of sarcoidosis in dependence on HLA-DRB1 allele frequencies, inflammatory markers, and the presence of M. tuberculosis DNA fragments. Sarcoidosis, vasculitis, and diffuse .
9. Edelson E. Isoniazid in the treatment of sarcoidosis; a preliminary report. J Invest Dermatol. août 1953;21(2):71 4. .
10. Brownell I, Ramírez-Valle F, Sanchez M, Prystowsky S. Evidence for mycobacteria in sarcoidosis. Am J Respir Cell Mol Biol. 2011 Nov;45(5):899-905. doi: 10.1165/rcmb.2010-0433TR. Epub 2011 Jun 9. PMID: 21659662; PMCID: PMC3361363.
11. Moller DR: Treatment of sarcoidosis - from a basic science point of view. J Intern Med 2003;253:31-40.
12. Drake WP, Newman LS: Mycobacterial antigens may be important in sarcoidosis pathogenesis. Curr Opin Pulm Med 2006;12:359-363.
13. Gupta D, Agarwal R, Aggarwal AN, Jindal SK. Sarcoidosis and tuberculosis: the same disease with different manifestations or similar manifestations of different disorders. Curr Opin Pulm Med. 2012;18:506–516.
14. Maaloune et al, Une sarcoïdose dans le décours d’une tuberculose. Rev Med Liege 2019; 74 : 7-8 : 394-400