Exploring Histologic Emphysema in a Rural Lobectomy Cohort: Insights and a Review Correlations of Histologic Emphysema
Main Article Content
Rahul G. Sangani, MD
http://orcid.org/0000-0002-6459-1298
Vishal Deepak
Bhanusowmya Buragamadagu
Andrew J. Ghio
http://orcid.org/0000-0002-6459-1298
Vishal Deepak
Bhanusowmya Buragamadagu
Andrew J. Ghio
Abstract
Exposure to cigarette smoking is extensive in rural Appalachia where one in four adults’ smokes. The clinical implications of this habit are evident among patients with some of the highest national rates for chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Individuals undergoing surgical lung resection for suspicious lung nodules or masses at a major rural academic center in the area demonstrated an excessive burden of histologic emphysema (73.5%). This destructive process of the alveoli was linked to a significant burden of comorbid conditions, various radiologic patterns of interstitial lung diseases and interstitial lung abnormalities, histologic fibrosis, inflammatory processes (respiratory bronchitis, desquamative interstitial pneumonia, peribronchiolar metaplasia), anthracosis, and lung cancer. Physiologically, this combination of injuries imposed substantial limitations. Findings presented may enhance the understanding of concurrent changes occurring in the smoker. The complex inter-relationships and disparities between clinical COPD, radiologic and histologic emphysema are defined. While emphysema remains an irreversible pathology, associated inflammatory and fibrotic conditions are possibly amenable to earlier smoking cessation strategies and available disease-modifying therapies.
Keywords:
Cigarette Smoking, Emphysema, Fibrosis, Histology, Radiology, Smoking Cessation
Article Details
How to Cite
SANGANI, Rahul G. et al.
Exploring Histologic Emphysema in a Rural Lobectomy Cohort: Insights and a Review.
Medical Research Archives, [S.l.], v. 12, n. 4, apr. 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/5265>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.18103/mra.v12i4.5265.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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