Effectiveness of a proprietary Dichrostachys glomerata extract (DYG-400®) on Adult's Sleep Quality and Activity: A Pilot Trial

Article Sidebar

11-May-5268.pdf
Published May 14, 2024
DOI: https://doi.org/10.18103/mra.v12i4.5268

Downloads

Download data is not yet available.

Submit your own article

Register as an author to reserve your spot in the next issue of the Medical Research Archives.

Author Registration

Join the Society

The European Society of Medicine is more than a professional association. We are a community. Our members work in countries across the globe, yet are united by a common goal: to promote health and health equity, around the world.

Join Europe’s leading medical society and discover the many advantages of membership, including free article publication.

Membership

Main Article Content

Heather A. Hausenblas, PhD
Jacksonville University
Tarah Lynch, MS
Jacksonville University
Shaylee Beefus
Wellness Discovery Labs
Tiffany Braverman
Wellness Discovery Labs
Stephanie Hooper, MPH
University of North Florida

Abstract

Objectives: The purpose of this study was to examine the effectiveness of Dichrostachys glomerata (Dyglomera®) supplementation on adults’ sleep quality and daytime activity.


Methods: Using a double-blind placebo-controlled pilot trial, 56 adults with nonclinical poor sleep (M age = 44.50) were randomized to either the Dichrostachys glomerata Group (300 mg/d) or Placebo Group for 60 days. Outcomes were the self-reported Insomnia Severity Index and objective sleep and daytime activity via the Oura Ring. Analysis was undertaken at Day 0 (Baseline), Day 30, and Day 60.


Results: The Dichrostachys glomerata Group had improved Insomnia Severity Index symptoms, with significant improvements from Day 0 to Day 60. Objective sleep measures indicated that the Dichrostachys glomerata Group had significantly improved sleep score and deep sleep duration, while the Placebo Group declined in these parameters. The Dichrostachys glomerata Group also improved on sleep latency and time awake, contrasting with worsened of these sleep metrics in the Placebo Group, p’s < .05. No group differences were found for REM. The Dichrostachys glomerata Group improved significantly on the activity outcomes.


Conclusion: These results provide preliminary support for the potential of Dichrostachys glomerata supplementation to enhance both sleep and daytime activity. Further research is warranted to validate these findings in diverse populations. Clinical trial registry = ISRCTN10099861.

Keywords: Sleep quality, activity, intervention

Article Details

How to Cite
HAUSENBLAS, Heather A. et al. Effectiveness of a proprietary Dichrostachys glomerata extract (DYG-400®) on Adult's Sleep Quality and Activity: A Pilot Trial. Medical Research Archives, [S.l.], v. 12, n. 4, may 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5268>. Date accessed: 30 dec. 2024. doi: https://doi.org/10.18103/mra.v12i4.5268.
ABNT APA BibTeX CBE EndNote - EndNote format (Macintosh & Windows) MLA ProCite - RIS format (Macintosh & Windows) RefWorks Reference Manager - RIS format (Windows only) Turabian
Issue
Vol 12 No 4 (2024): April issue, Vol.12, Issue 4
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

References

1. Weinberg MK, Noble JM, Hammond TG. Sleep well feel well: An investigation into the protective value of sleep quality on subjective well-being. Aust J Psychol. 2016;68:91–97. Doi: 10.1111/ajpy.12098.
2. Baglioni C, Nanovska S, Regen W, et al. Sleep and mental disorders: A meta-analysis of polysomnographic research. Psychol Bull. 2016;142(9):969-990. Doi: 10.1037/bul0000053.
3. Suzuki M, Suzuki N, Sakurada K, Tsuchiya N, Ueno Y, Konta T. Insomnia symptoms and related factors in a community-based population: The Yamagata Cohort study. Heliyon. 2024;10(6):e28228. Doi: 10.1016/j.heliyon.2024.e28228.
4. Gingerich SB, Seaverson ELD, Anderson DR. Association between sleep and productivity loss among 598,676 employees from multiple industries. Am J Health Promot. 2018;32:1091–4. Doi: 10.1177/0890117117722517.
5. Ma Y, Liang L, Zheng F, Shi L, Zhong B, Xie W. Association between sleep duration and cognitive decline. JAMA Netw Open. 2020; 3:e2013573. Doi: 10.1001/jamanetworkopen.2020.13573.
6. Ohayon MM. Epidemiological overview of sleep disorders in the general population. Sleep Med Res. 2011; 2:1–9. Doi: 10.17241/smr.2011.2.1.1.
7. Kim J, Lee SL, Kang I, et al. Natural products from single plants as sleep aids: A systematic review. J Med Food. 2018; 21:433–44. Doi: 10.1089/jmf.2017.4064.
8. Borrás S, Martínez-Solís I, Ríos JL. Medicinal plants for insomnia related to anxiety: An updated review. Planta Med. 2021;87(10-11):738-753. Doi: 10.1055/a-1510-9826.
9. Djiazet S, Mezajoug Kenfack, LD, Linder M, Tchiégang C. An ethno-nutritional study on spices used in traditional foods of the Western Regions of Cameroon: the case of nah poh. J Ethn Foods. 019; 6(1). DOI:10.1186/s42779-019-0030-6.
10. Djuissi NM, Ngoula F, Kouamo J, et al. Reproductive characteristics, serum metabolites, and oxidative status in female guinea pigs (Cavia porcellus) fed with ethanolic extract of Dichrostachys glomerata fruit. World Vet J. 2021; 11:66–72. Doi: 10.54203/scil.2021.wvj9.
11. Etoundi CB, Kuaté D, Ngondi JL, Oben J. Anti-amylase, anti-lipase and antioxidant effects of aqueous extracts of some Cameroonian spices. J Nat Prod. 2010; 3:17.
12. Kuate D, Etoundi BCO, Soukontoua YB, Ngondi JL, Oben JE. Antioxidant characteristics of Dichrostachys glomerata spice extracts. CYTA J Food. 2010;8:23–37. Doi: 10.1080/19476330903129126.
13. Kuate D, Kegne APN, Dakam W, Etoundi BCO, Paka GD. Effectiveness of Dichrostachys glomerata spice phenolics in reduction of oxidative stress associated with obesity and type 2 diabetes; A randomized, double-blind placebo-controlled clinical trial. J Food Res. 2013; 2:887–895.
14. Kuate D, Etoundi BC, Ngondi JL, Oben JE. Effects of Dichrostachys glomerata spice on cardiovascular diseases risk factors in normoglycemic and type 2 diabetic obese volunteers. Food Res Int. 2011;44:1197–1202. Doi: 10.1016/j.foodres.2010.09.037.
15. Kuate D, Etoundi BC, Ngondi JL, Manan WA, Muda BW, Oben JE. Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (hydroethanolic extract of Dichrostachys glomerata) in obese patients with metabolic syndrome. Funct Foods Health Dis. 2013;3:416–427. Doi: 10.31989/ffhd.v3i11.35.
16. Atrooz F, Salim S. Sleep deprivation, oxidative stress and inflammation. Adv Protein Chem Struct Biol. 2020;119:309-336. Doi: 10.1016/bs.apcsb.2019.03.001.
17. Bastien CH, Vallières A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297-307. Doi: 10.1016/s1389-9457(00)00065-4.
18. de Zambotti, M, Rosas, L, Colrain, IM, Baker, FC. The sleep of the ring: Comparison of the ŌURA sleep tracker against polysomnography. Behav Sleep Med. 2019;17(2):124-136. Doi: 10.1080/15402002.2017.1300587.
19. Kinnunen H, Rantanen A, Kenttä T, Koskimäki T. Feasible assessment of recovery and cardiovascular health: accuracy of nocturnal HR and HRV assessed via ring PPG in comparison to medical grade ECG. Physiol Meas. 2020; 7;41(4):04NT01. Doi: 10.1088/1361-6579/ab840a.
20. Mehrabadi MA, Azimi I, Sarhaddi F et al., Sleep Tracking of a Commercially Available Smart Ring and Smartwatch Against Medical-Grade Actigraphy in Everyday Settings: Instrument Validation Study. JMIR Mhealth Uhealth. 2020; 8(10): e20465. Doi: 10.2196/20465.
21. Kothari SC, Shivarudraiah P, Venkataramaiah SB, Gavara S, Arumugam N, Soni MG. Toxicologic evaluation of Dichrostachys glomerata extract: Subchronic study in rats and genotoxicity tests. Food Chem Toxicol. 2014;69: 120-31. Doi: 10.1016/j.fct.2014.03.045.
22. Chan V, Lo K. Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis. Postgrad Med J. 2022;98(1158):285-293. Doi: 10.1136/postgradmedj-2020-139319.