French National Trends in Neurodevelopmental and Mental Health-Related Healthcare Center Visits among Youth, 2014-2022: Towards Sex Specificities in the Care Pathway

Main Article Content

Vanessa Douet-Vannucci Mouna Chebli Lucie Isoline Pisella Pascal Staccini

Abstract

Background: Neurodevelopmental disorders (NDD) and mental health (MH)-related conditions among children and adolescents, represent a global public health burden, that was worsened by the COVID-19 pandemic due to disruptions in access to healthcare, support services, and increased stressors exacerbating symptoms and challenges. However, few studies have examined in France, NDD and MH’s diagnoses and care pathway in youth attending public healthcare center (HCC) services.


Methods: An annual cross-sectional analysis was performed in youth aged 0 to 17 years on health information, that were extracted from the French PMSI database (DIAMANT database) between January 1, 2014, and December 31, 2022, using the MH-related ICD-10 diagnosis codes, including NDD, mood-, behavior-, anxiety-, and other-disorders (sleep and eating). Trends in healthcare center visits for NDD and MH-related conditions, were evaluated according to age, sex, diagnoses, and care pathway over the 10-year period using ANOVAs.


Findings: Out of the 17,707,806 total HCC-visits across a 10-year period, 289,382 visits (1,6%) were related to youth with diagnoses for NDD or MH disorders of the study interest. Among them, 57% were girls and 43% boys. The total number of pediatric HCC-visits related to NDD and MH has remained stable from 2014 to 2022. However, the proportion of visits has doubled for adolescent girls with internalizing disorders (anxiety and mood) while a 5-fold decrease in the proportion of visits for NDD, was observed for boys aged 0 to 12 years. The HCC-admission mainstream for internalizing disorders was the emergency department and was “home” for the NDD. While the HCC-discharge accounted for 9% of patients being hospitalized, most of them were sent home (90.7%) with a strong age- and sex-specificities.


Interpretation: Over the last 10 years, the proportion of HCC visits for NDD and MH remained stable, but strong age- and sex-effects were found on diagnoses visits and care pathway. These findings are essential to improve emergency and outpatient service capacity dedicated to youth. They could help European and national policies to patient-tailor care pathway depending on sex and diagnosis from screening, interventions, and monitoring during this sensitive period of development.

Article Details

How to Cite
DOUET-VANNUCCI, Vanessa et al. French National Trends in Neurodevelopmental and Mental Health-Related Healthcare Center Visits among Youth, 2014-2022: Towards Sex Specificities in the Care Pathway. Medical Research Archives, [S.l.], v. 12, n. 3, apr. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5286>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.18103/mra.v12i3.5286.
Section
Research Articles

References

1. Hewlett E, Moran V. Making Mental Health Count: The Social and Economic Costs of Neglecting Mental Health Care. OECD Health Policy Studies, Éditions OCDE, Paris. Published online 2014.
2. Arias D, Saxena S, Ephane Verguet S. Quantifying the global burden of mental disorders and their economic value. EClinicalMedicine. 2022;54:101675. doi:10.1016/j
3. Abbafati C, Abbas KM, Abbasi M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1204-1222. doi:10.1016/S0140-6736(20)30925-9
4. Santomauro DF, Mantilla Herrera AM, Shadid J, et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. The Lancet. 2021;398(10312):1700-1712. doi:10.1016/S0140-6736(21)02143-7
5. Sacco R, Camilleri N, Eberhardt J, Umla-Runge K, Newbury-Birch D. A systematic review and meta-analysis on the prevalence of mental disorders among children and adolescents in Europe. Eur Child Adolesc Psychiatry. Published online 2022. doi:10.1007/s00787-022-02131-2
6. Cacioppo M, Bouvier S, Bailly R, et al. Emerging health challenges for children with physical disabilities and their parents during the COVID-19 pandemic: The ECHO French survey. Ann Phys Rehabil Med. 2021;64(3). doi:10.1016/j.rehab.2020.08.001
7. Diagnostic and Statistical Manual of Mental Disorders, Text Revision Dsm-5-Tr . 5th-TR ed. American Psychiatric Association; 2022.
8. World Health Organization(WHO). The ICD-10 classification of mental and behavioural disorders. World Health Organization. Published online 1993.
9. Snowling MJ, Hulme C, Nation K. Defining and understanding dyslexia: past, present and future. Oxf Rev Educ. 2020;46(4):501-513. doi:10.1080/03054985.2020.1765756
10. Pennington BF. From single to multiple deWcit models of developmental disorders. Cognition. 2006;101:385-413. doi:10.1016/j.cognition.2006.04.008
11. Soppelsa R, Albaret JM, Corraze J. Les comorbidités : théorie et prise de décision thérapeutique. Published online 2009.
12. Astle DE, Holmes J, Kievit R, Gathercole SE. Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders. Journal of Child Psychology and Psychiatry. 2022;63(4):397-417. doi:10.1111/JCPP.13481
13. Hansen BH, Oerbeck B, Skirbekk B, Petrovski BÉ, Kristensen H. Neurodevelopmental disorders: prevalence and comorbidity in children referred to mental health services. Nord J Psychiatry. 2018;72(4):285-291. doi:10.1080/08039488.2018.1444087
14. Francés L, Ruiz A, Soler CV, et al. Prevalence, comorbidities, and profiles of neurodevelopmental disorders according to the DSM-5-TR in children aged 6 years old in a European region. Front Psychiatry. 2023;14. doi:10.3389/fpsyt.2023.1260747
15. Chiang H, Gau SS. Comorbid psychiatric conditions as mediators to predict later social adjustment in youths with autism spectrum disorder. Journal of Child Psychology and Psychiatry. 2016;57(1):103-111. doi:10.1111/jcpp.12450
16. Copeland WE, Wolke D, Shanahan L, Costello J. Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study. JAMA Psychiatry. 2015;72(9):892-899. doi:10.1001/JAMAPSYCHIATRY.2015.0730
17. Missiuna C, Cairney J, Pollock N, et al. Psychological distress in children with developmental coordination disorder and attention-deficit hyperactivity disorder. Res Dev Disabil. 2014;35(5):1198-1207. doi:10.1016/J.RIDD.2014.01.007
18. van Steensel FJA, Bögels SM, de Bruin EI. Psychiatric Comorbidity in Children with Autism Spectrum Disorders: A Comparison with Children with ADHD. J Child Fam Stud. 2013;22(3):368-376. doi:10.1007/S10826-012-9587-Z/TABLES/4
19. Operto FF, Smirni D, Scuoppo C, et al. Neuropsychological Profile, Emotional/Behavioral Problems, and Parental Stress in Children with Neurodevelopmental Disorders. Published online 2021. doi:10.3390/brainsci11050584
20. Carta A, Fucà E, Guerrera S, Napoli E, Valeri G, Vicari S. Characterization of Clinical Manifestations in the Co-occurring Phenotype of Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder. Front Psychol. 2020;11. doi:10.3389/fpsyg.2020.00861
21. Lecavalier L, McCracken CE, Aman MG, et al. An exploration of concomitant psychiatric disorders in children with autism spectrum disorder. Compr Psychiatry. 2019;88:57-64. doi:10.1016/J.COMPPSYCH.2018.10.012
22. Hong JS SVKLE 2020 O 19. P 33073542. Attention Deficit Hyperactivity Disorder Symptoms in Young Children with Autism Spectrum Disorder. Autism Research. 2021;14(1):182-192.
23. Bourke E, Barker C, Fornells‐Ambrojo M. Systematic review and meta‐analysis of therapeutic alliance, engagement, and outcome in psychological therapies for psychosis. Psychology and Psychotherapy: Theory, Research and Practice. 2021;94(3):822-853. doi:10.1111/papt.12330
24. Kalb LG, Stapp EK, Ballard ED, Holingue C, Keefer A, Riley A. Trends in Psychiatric Emergency Department Visits Among Youth and Young Adults in the US. Published online 2019. doi:10.1542/peds.2018-2192
25. Lo CB, Bridge JA, Shi J, Ludwig L, Stanley RM. Children’s Mental Health Emergency Department Visits: 2007–2016. Pediatrics. 2020;145(6). doi:10.1542/peds.2019-1536
26. Cutler GJ, Rodean J, Zima BT, et al. Trends in Pediatric Emergency Department Visits for Mental Health Conditions and Disposition by Presence of a Psychiatric Unit. Acad Pediatr. 2019;19(8):948-955. doi:10.1016/j.acap.2019.05.132
27. Leeb RT, Bitsko RH, Radhakrishnan L, Martinez P, Njai R, Holland KM. Mental Health–Related Emergency Department Visits Among Children Aged <18 Years During the COVID-19 Pandemic — United States, January 1–October 17, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(45):1675-1680. doi:10.15585/mmwr.mm6945a3
28. Radhakrishnan L, Leeb RT, Bitsko RH, et al. Pediatric Emergency Department Visits Associated with Mental Health Conditions Before and During the COVID-19 Pandemic — United States, January 2019–January 2022. MMWR Morb Mortal Wkly Rep. 2022;71(8):319-324. doi:10.15585/mmwr.mm7108e2
29. Krass P, Dalton E, Doupnik SK, Esposito J. US Pediatric Emergency Department Visits for Mental Health Conditions During the COVID-19 Pandemic. JAMA Netw Open. 2021;4(4):e218533. doi:10.1001/jamanetworkopen.2021.8533
30. Jensen CM, Steinhausen HC. Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. ADHD Attention Deficit and Hyperactivity Disorders. 2015;7(1):27-38. doi:10.1007/s12402-014-0142-1
31. Lai MC, Kassee C, Besney R, et al. Prevalence of co-occurring mental health diagnoses in the autism population: a systematic review and meta-analysis. Lancet Psychiatry. 2019;6(10):819-829. doi:10.1016/S2215-0366(19)30289-5
32. Solmi M, Radua J, Olivola M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry. 2022;27(1):281-295. doi:10.1038/s41380-021-01161-7
33. Bölte S, Neufeld J, Marschik PB, Williams ZJ, Gallagher L, Lai MC. Sex and gender in neurodevelopmental conditions. Nat Rev Neurol. 2023;19(3):136-159. doi:10.1038/s41582-023-00774-6
34. Bommersbach TJ, McKean AJ, Olfson M, Rhee TG. National Trends in Mental Health–Related Emergency Department Visits Among Youth, 2011-2020. JAMA. 2023;329(17):1469. doi:10.1001/jama.2023.4809
35. 4 ans de mise en œuvre de la stratégie nationale autisme et troubles du neuro-développement. handicap.gouv.fr. Published 2022. Accessed January 5, 2024. https://handicap.gouv.fr/4-ans-de-mise-en-oeuvre-de-la-strategie-nationale-autisme-et-troubles-du-neuro-developpement
36. HAS. RECOMMANDATION DE BONNE PRATIQUE OBJECTIFS Troubles Du Neurodéveloppement Repérage et Orientation Des Enfants à Risque Synthèse.; 2020. www.handicap.gouv.fr/plateformes-TND
37. Mojtabai R, Olfson M, Han B. National Trends in the Prevalence and Treatment of Depression in Adolescents and Young Adults. Pediatrics. 2016;138(6). doi:10.1542/peds.2016-1878
38. Hoertel N, Franco S, Wall MM, et al. Mental disorders and risk of suicide attempt: a national prospective study. Mol Psychiatry. 2015;20(6):718-726. doi:10.1038/mp.2015.19
39. Neufeld SAS. The burden of young people’s mental health conditions in Europe: No cause for complacency. The Lancet Regional Health - Europe. 2022;16:100364. doi:10.1016/j
40. Gershon J. A meta-analytic review of gender differences in ADHD. Journal of Attention Disorders. 2022;5(3):143-154.
41. Hinshaw SP NPOSREA. Annual Research Review: Attention-deficit/hyperactivity disorder in girls and women: underrepresentation, longitudinal processes, and key directions. Journal of Child Psychology and Psychiatry. 2022;63(4):484-496.
42. Sacco R, Camilleri N, Eberhardt J, Umla-Runge K, Newbury-Birch D. A systematic review and meta-analysis on the prevalence of mental disorders among children and adolescents in Europe. Eur Child Adolesc Psychiatry. Published online December 30, 2022. doi:10.1007/s00787-022-02131-2
43. Breslau J, Gilman SE, Stein BD, Ruder T, Gmelin T, Miller E. Sex differences in recent first-onset depression in an epidemiological sample of adolescents. Nature Publishing Group. 2017;7. doi:10.1038/tp.2017.105
44. Lo CB, Bridge JA, Shi J, Ludwig L, Stanley RM. Children’s Mental Health Emergency Department Visits: 2007–2016. Pediatrics. 2020;145(6). doi:10.1542/peds.2019-1536
45. Chevreul K, Brigham KB, Durand-Zaleski I, Hernández-Quevedo C. Health Systems in Transition: France Vol. 17 No. 3 2015. Vol 17.; 2015.
46. Laporte C, Fortin F, Dupouy J, et al. The French ecology of medical care. A nationwide population-based cross sectional study. Fam Pract. Published online November 2, 2023. doi:10.1093/fampra/cmad098
47. Munro M BKPNHMONCDSNGA. Quality and accessibility of written development assessment reports provided to caregivers in a publicly funded child developmental assessment service. Autism. 2023;27(6):1764-1776.
48. Crane L CJGLHLHE. Experiences of autism diagnosis: A survey of over 1000 parents in the United Kingdom. Autism. 2016;20(2):153-162.
49. Boulton KA, Guastella AJ, Hodge MA, Demetriou EA, Ong N, Silove N. Mental health concerns in children with neurodevelopmental conditions attending a developmental assessment service. J Affect Disord. 2023;335:264-272. doi:10.1016/j.jad.2023.04.098
50. (previously Marzena Szkodo) MOR, Micai M, Caruso A, Fulceri F, Fazio M, Scattoni ML. Technologies to support the diagnosis and/or treatment of neurodevelopmental disorders: A systematic review. Neurosci Biobehav Rev. 2023;145. doi:10.1016/j.neubiorev.2022.105021